Moonlighting on theFasciola hepaticategument: enolase, a glycolytic enzyme, interacts with the extracellular matrix and fibrinolytic system of the host
Eve O’Kelly,
Krystyna Cwiklinski,
Carolina De Marco Verissimo
et al.
Abstract:Enolase is a 47 kDa enzyme that functions within the glycolysis and gluconeogenesis pathways involved in the reversible conversion of D-2-phosphoglycerate (2PGA) to phosphoenolpyruvate (PEP). However, in the context of host-pathogen interactions, enolase from different species of parasites, fungi and bacteria have been shown to contribute to adhesion processes by binding to proteins of the host extracellular matrix (ECM), such as fibronectin (FN) or laminin (LM). In addition, enolase is a plasminogen (PLG)-bin… Show more
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