Mood disorders and sexual functioning in women with functional hypothalamic amenorrhea

Dundon, Carolyn M.; Rellini, Alessandra H.; Tonani, Silvia; Santamaria, Valentina; Nappi, Rossella E.

doi:10.1016/j.fertnstert.2010.01.012

Cited by 22 publications

(13 citation statements)

References 35 publications

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“…One study investigated this hypothesis and showed an association between functional hypothalamic amenorrhea and sexual dysfunction. 30 Another sub-population worth investigating is women with eating disorders and low BMI. Numerous studies have demonstrated that women with anorexia nervosa have decreased libido, as well as increased sexual anxiety and sexual dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Sexual Pain Among Physically Active Women

et al. 2020

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Introduction: Sexual pain is common among women but little is known about associations with exercise and physical activity. Aim: To determine the prevalence of sexual pain among physically active women and to evaluate cycling and other potential risk factors. Methods: This is a secondary data analysis of a study on the urinary and sexual wellness of physically active women recruited through sporting clubs and targeted social media advertising. We used multivariable logistic regression to assess the role of cycling and exercise in reporting any, frequent, or severe sexual pain, controlling for demographic, relationship, and health risk factors. Main outcome measure: Sexual pain, including frequency and severity, was measured using the Female Sexual Function Index. Results: A total of 2,039 women were included, with 1,097 (54%) reporting any level of sexual pain, 364 (18%) experiencing frequent pain, and 378 (19%) reporting severe pain. Less than 5% of women reported diabetes or hypertension, and the cohort had a median body mass index of 23.3 (interquartile range 21.4e25.7). Increasing age and body mass index were protective against any sexual pain, as was cycling (odds ratio [OR] 0.73 [95% CI 0.59e0.90]). Participants who reported being "moderately satisfied" (OR 0.53 [95% CI 0.31e0.91]) or "very satisfied" (OR 0.33 [95% CI 0.19e0.56]) with their emotional closeness to a sexual partner had decreased odds of any sexual pain. Conclusion: Experiencing any sexual pain is common in physically active women, with a prevalence of over 50%; however, weekly energy expenditure from exercise was not associated with sexual pain. Cycling participation and higher levels of emotional closeness and intimacy were associated with less pain. Patients between the ages of 18 and 30 years who were normal or underweight incurred the highest risk of sexual pain. Fergus KB, Cohen AJ, Cedars BE, et al. Risk Factors for Sexual Pain Among Physically Active Women. Sex Med 2020;8:501e509.

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Section: Discussionmentioning

confidence: 99%

Risk Factors for Sexual Pain Among Physically Active Women

et al. 2020

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“…Menstrual cycle irregularities, such as functional hypothalamic amenorrhoea [45] and polycystic ovarian syndrome [46], are associated with increased rates of CVD and its risk factors, even in premenopausal women. Likewise, young women with functional hypothalamic amenorrhoea [47] and polycystic ovarian syndrome [48] tend to have higher levels of depression, anxiety and perceived stress than those without. In addition, the natural decline in reproductive hormones, such as oestrogen [49] and anti-Mullerian hormone [50], experienced by women during the menopausal transition may increase vulnerability to CVD; a period which is also characterised by higher depression and anxiety symptoms than that prior to menopause [51].…”

Section: Biological Factorsmentioning

confidence: 99%

How Does Mental Health Impact Women's Heart Health?

O’Neil

Russell

Murphy

2021

Heart, Lung and Circulation

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From adolescence until old age, women are more vulnerable to common mental disorders (CMDs; depression and anxiety) than men at all stages of the life course. By middle age, women who have clinical depression are at twice the risk of having an incident cardiovascular disease (CVD) than those without. This has important implications for the way we prevent, identify and treat both CMDs and coronary heart disease in women. In this paper, we discuss the various genetic, biological, ethnic/racial, and psychological pathways by which women's vulnerability to CMDs elevate their CVD risk and recovery from a cardiac event. We review the evidence from trials that have, to date, failed to show that treating depression can reduce or delay the onset or recurrence of CVD events, especially for female patients. We discuss the value of lifestyle-based therapies for treating depression, to which women may be more responsive, and finish by discussing how population-based approaches including risk factor assessment could be tailored to consider these factors.

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“…Sexual functioning is also of important significance for FHA patients. Dundon et al [ 70 ] found that women with FHA have more sexual problems than healthy controls. Theoretically, this functioning is determined by the psychological and hormonal background.…”

Section: Mental and Sexual Dysfunctionmentioning

confidence: 99%

Functional hypothalamic amenorrhea and its influence on women’s health

Męczekalski

Kołodziejczyk

Czyźyk

et al. 2014

J Endocrinol Invest

131

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IntroductionFunctional hypothalamic amenorrhea (FHA) is one of the most common causes of secondary amenorrhea. There are three types of FHA: weight loss-related, stress-related, and exercise-related amenorrhea. FHA results from the aberrations in pulsatile gonadotropin-releasing hormone (GnRH) secretion, which in turn causes impairment of the gonadotropins (follicle-stimulating hormone and luteinizing hormone). The final consequences are complex hormonal changes manifested by profound hypoestrogenism. Additionally, these patients present mild hypercortisolemia, low serum insulin levels, low insulin-like growth factor 1 (IGF-1) and low total triiodothyronine.AimThe aim of this work is to review the available data concerning the effects of FHA on different aspects of women’s health.ResultsFunctional hypothalamic amenorrhea is related to profound impairment of reproductive functions including anovulation and infertility. Women’s health in this disorder is disturbed in several aspects including the skeletal system, cardiovascular system, and mental problems. Patients manifest a decrease in bone mass density, which is related to an increase in fracture risk. Therefore, osteopenia and osteoporosis are the main long-term complications of FHA. Cardiovascular complications include endothelial dysfunction and abnormal changes in the lipid profile. FHA patients present significantly higher depression and anxiety and also sexual problems compared to healthy subjects.ConclusionsFHA patients should be carefully diagnosed and properly managed to prevent both short- and long-term medical consequences.

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Mood disorders and sexual functioning in women with functional hypothalamic amenorrhea

Cited by 22 publications

References 35 publications

Risk Factors for Sexual Pain Among Physically Active Women

Risk Factors for Sexual Pain Among Physically Active Women

How Does Mental Health Impact Women's Heart Health?

Functional hypothalamic amenorrhea and its influence on women’s health

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