Mood-congruent memory in depression: Emotional priming or elaboration?

Watkins, Philip C.; Mathews, Andrew; Williamson, Donald A.; Fuller, Richard D.

doi:10.1037/0021-843x.101.3.581

Cited by 160 publications

(138 citation statements)

References 39 publications

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“…The enhancing effect of amygdala activity on emotional memory consolidation is a wellestablished finding in the imaging literature relating activity in the amygdala to later retrieval success (Cahill et al 1996;Canli et al 2000;Dolcos et al 2004Dolcos et al , 2005Hamann et al 1999;rev: LaBar and Cabeza 2006). In addition, negative memory biases are often found in stressrelated disorders (e.g., Bradley et al 1996;Ridout et al 2009;Watkins et al 1992). In accordance with this, depressed patients were found to show an increased coupling between the amygdala and the hippocampus during encoding of negative emotional stimuli, presenting a possible explanation for the increased negative emotional memory (Hamilton and Gotlib 2008).…”

Section: Discussionmentioning

confidence: 99%

Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume

et al. 2014

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Accumulating evidence suggests a role of FKBP5, a co-chaperone regulating the glucocorticoid receptor sensitivity, in the etiology of depression and anxiety disorders. Based on recent findings of altered amygdala activity following childhood adversity, the present study aimed at clarifying the impact of genetic variation in FKBP5 on threat-related neural activity and coupling as well as morphometric alterations in stress-sensitive brain systems. Functional magnetic resonance imaging during an emotional face-matching task was performed in 153 healthy young adults (66 males) from a high-risk community sample followed since birth. Voxel-based morphometry was applied to study structural alterations and DNA was genotyped for FKBP5 rs1360780. Childhood adversity was measured using retrospective selfreport (Childhood Trauma Questionnaire) and by a standardized parent interview assessing childhood family adversity. Depression was assessed by the Beck Depression Inventory. There was a main effect of FKBP5 on the left amygdala, with T homozygotes showing the highest activity, largest volume and increased coupling with the left hippocampus and the orbitofrontal cortex (OFC). Moreover, amygdala-OFC coupling proved to be associated with depression in this genotype. In addition, our results support previous evidence of a gene-environment interaction on right amygdala activity with respect to retrospective assessment of childhood adversity, but clarify that this does not generalize to the prospective assessment. These findings indicated that activity in T homozygotes increased with the level of adversity, whereas the opposite pattern emerged in C homozygotes, with CT individuals being intermediate. Abstract Accumulating evidence suggests a role of FKBP5, a co-chaperone regulating the glucocorticoid receptor sensitivity, in the etiology of depression and anxiety disorders. Based on recent findings of altered amygdala activity following childhood adversity, the present study aimed at clarifying the impact of genetic variation in FKBP5 on threat-related neural activity and coupling as well as morphometric alterations in stresssensitive brain systems. Functional magnetic resonance imaging during an emotional face-matching task was performed in 153 healthy young adults (66 males) from a high-risk community sample followed since birth. Voxelbased morphometry was applied to study structural alterations and DNA was genotyped for FKBP5 rs1360780. Childhood adversity was measured using retrospective selfreport (Childhood Trauma Questionnaire) and by a standardized parent interview assessing childhood family adversity. Depression was assessed by the Beck Depression Inventory. There was a main effect of FKBP5 on the left amygdala, with T homozygotes showing the highest activity, largest volume and increased coupling with the left hippocampus and the orbitofrontal cortex (OFC). Moreover, amygdala-OFC coupling proved to be associated with depression in this genotype. In addition, our results support previous evidence of a gene-env...

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Section: Discussionmentioning

confidence: 99%

Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume

et al. 2014

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“…Hertel et al demonstrated that intrusions during recall reflected the content of socially anxious interpretations of ambiguous scenarios, whereas we showed that the valence of such intrusions was consistent with the valence of CBM-I training. Given the evidence for memory biases in depression (Matt et al, 1992;Watkins, Mathews, Williamson, & Fuller, 1992), the increasing evidence for memory bias in anxiety when interpretation is taken into account (e.g., Hertel et al, 2008;Lundt & Ost, 1996), and the potential benefits from training positive biases on emotion regulation and stress reactivity, investigating the connection between interpretation and memory is a critical area for further exploration. The tendency to respond to negative events and mood states with rumination, for example, is an important risk factor for the onset of depression (Nolen-Hoeksema, Wisco, & Lyubomirsky, 2008).…”

Section: Discussionmentioning

confidence: 99%

Cognitive bias modification: Induced interpretive biases affect memory.

Tran¹,

Hertel²,

Joormann³

2011

Emotion

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Previous research has shown that it is possible to experimentally induce interpretive biases using ambiguous scenarios. This study extends past findings by examining the effects of cognitive bias modification for interpretation on subsequent scenario recall. Participants were trained to interpret emotionally ambiguous passages in either a positive or negative direction. Transfer of the training to novel scenarios was tested. After training, participants were also asked to recall details from these novel scenarios. The results indicate that the training was effective in inducing the intended group differences in interpretive bias. Importantly, participants exhibited memory biases that corresponded to their training condition. These results suggest that manipulating interpretive biases can result in corresponding changes in memory. Findings from this study highlight the importance of future research on the relation among cognitive biases and on the possibility of modifying cognitive biases in emotional disorders.

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“…Indirect tests are carefully designed to insure that participants do not deliberately think back to a prior experimental phase as they are spelling homophones, completing word fragments or word stems, or freely associating to cues. Indeed, no differences have been found on tests of homophone spelling (Hertel & Hardin, 1990), word completion (Danion et al, 1991;Denny & Hunt, 1992;Watkins, Mathews, Williamson, & Fuller, 1992), or free association (Watkins, Vache, Verney, Muller, & Mathews, 1996). Yet the extent to which a particular word comes to mind to provide a spelling, complete a stem, or relate to a cue should also reflect the extent to which that particular word was attended initially.…”

Section: Depression and Memory 49mentioning

confidence: 99%

The cognitive-initiative account of depression-related impairments in memory

Hertel¹

2000

Psychology of Learning and Motivation

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Mood-congruent memory in depression: Emotional priming or elaboration?

Cited by 160 publications

References 39 publications

Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume

Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume

Cognitive bias modification: Induced interpretive biases affect memory.

The cognitive-initiative account of depression-related impairments in memory

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