Mood changes, obstetric experience and alterations in plasma cortisol, beta-endorphin and corticotrophin releasing hormone during pregnancy and the puerperium

Smith, Roger; Cubis, Jeff; Brinsmead, Maxwell; Lewin, Terry J.; Singh, Bruce; Owens, P. C.; Chan, Eng‐Cheng; Hall, Chris; Adler, Robert; Lovelock, Margaret; Hurt, Dianne; Rowley, Maralyn; Nolan, Mary

doi:10.1016/0022-3999(90)90008-r

Cited by 103 publications

(53 citation statements)

References 39 publications

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“…This dysregulation may be related to emotional and behavioral functioning during infancy and to the development of later emotional and behavioral problems (see Goodman & Gotlib for review). For example, studies of depressed, pregnant women have found that levels of hormones associated with depression and stress were abnormally elevated during pregnancy (Goodman & Gotlib;Smith et al, 1990). A single study (Glover, Teixeira, Gitau, & Fisk, 1998) indicated in addition, that variation of fetal levels of one of these hormones, cortisol, was explained by maternal levels at 20 to 36 weeks of pregnancy.…”

Section: Mediators Of the Relationship Of Parental Mental Illness Andmentioning

confidence: 99%

Critical Issues for Parents with Mental Illness and their Families

Nicholson¹,

Biebel²,

Hinden³

et al. 2001

PsycEXTRA Dataset

100

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Section: Mediators Of the Relationship Of Parental Mental Illness Andmentioning

confidence: 99%

Critical Issues for Parents with Mental Illness and their Families

Nicholson¹,

Biebel²,

Hinden³

et al. 2001

PsycEXTRA Dataset

100

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“…Chan et al [17] found no correlation between maternal plasma CRH and cortisol during delivery or the duration of labor, but in contrast, Smith et al [18] did report a correlation between maternal plasma CRH and cortisol during labor. Wolfe et al [8] were able to show an association between CRH levels, gestational age and weight gain during pregnancy, but with no other obstetric variable.…”

Section: Introductionmentioning

confidence: 96%

Childbirth as a Biological Model for Stress?

Bergant

Kirchler²,

Heim³

et al. 1998

Gynecol Obstet Invest

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Objective: The aims of this investigation were to measure corticotropin-releasing hormone (CRH), corticotropin (ACTH) and cortisol before, during and after delivery searching for an endocrine intercorrelation of the hypothalamic-pituitary-adrenal (HPA) axis and to correlate these findings with obstetrical variables. Methods: Blood was sampled from 50 women with singleton pregnancies at term without uterine contractions, during delivery (after full cervical dilatation) and on the 4th postnatal day. Hormones were measured by radioimmunoassay (RIA). The correlation between obstetric variables, sociodemographic and endocrine data were evaluated using the Spearman rank coefficient. Group comparisons for continuous variables were calculated using the Mann-Whitney U test and Kruskal-Wallis test. Results: Maternal plasma ACTH and cortisol increased significantly during labor, declining toward the 4th postnatal day (p < 0.001) and showing a significant intercorrelation (p < 0.01). Compared to women without uterine contractions CRH rose during labor (p < 0.05) and decreased rapidly to the 4th postnatal day (p < 0.001). No correlations between CRH and ACTH or cortisol were observed. None of the obstetrical variables (parity, newborn’s weight, duration of delivery) revealed any significant correlation with ACTH. Analgetic medication (pethidine hydrochloride) was not able to influence the endocrine response to labor stress. Conclusions: Stressful experience during childbirth has an impact on endocrine response. However, this is not fully evident along the HPA axis in a simple biological model with monocausal dependencies. This ‘biological stress model’ is not sensitive enough to detect different childbirth conditions and the hormones in the maternal compartment have partially fetal (placental) origin.

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“…During late pregnancy, the placenta, which has been shown to contain both the CRH peptide and its mRNA, is likely to be a major source of circulating CRH. Little is known about the regulation of the hormonal response to stress during pregnancy, despite its obvious implications for fetal and maternal well-being (1). Early studies on CRH within pregnant women focused on whether the peptide would influence the maternal HPA.…”

Section: Introductionmentioning

confidence: 99%

Corticotrophin-releasing hormone and ACTH levels in maternal and fetal blood during spontaneous and oxytocin-induced labour

et al. 2001

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The changes in corticotrophin-releasing hormone (CRH), ACTH and dehydroepiandrosterone (DHEA) in maternal and fetal plasma were estimated in women undergoing spontaneous and oxytocininduced labour to correlate hormone changes with the mode of parturition. Blood was sampled from a maternal peripheral vein 2 days before labour, during the second stage of labour and on the second postnatal day, and also from umbilical vessels just after delivery. Hormone concentrations were measured by RIA and ELSA methods. The maternal plasma CRH concentration before labour was significantly higher in the group of women delivered spontaneously and declined during the labour through to the second postnatal day. Measured in umbilical vessels, CRH as well as ACTH concentrations were higher in the umbilical vein than artery. The mean maternal plasma ACTH was similar in both groups before delivery, then increased significantly in both groups during the labour, decreasing on the second day after delivery. There were no changes in DHEA concentrations among the groups and at all time points of collection. No correlations between CRH and ACTH or DHEA were observed. Our results suggest that the maternal pituitary can respond to stress factors during delivery but peripheral CRH, probably mainly of placental origin, is not a major modulator of pituitary action.

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Mood changes, obstetric experience and alterations in plasma cortisol, beta-endorphin and corticotrophin releasing hormone during pregnancy and the puerperium

Cited by 103 publications

References 39 publications

Critical Issues for Parents with Mental Illness and their Families

Critical Issues for Parents with Mental Illness and their Families

Childbirth as a Biological Model for Stress?

Corticotrophin-releasing hormone and ACTH levels in maternal and fetal blood during spontaneous and oxytocin-induced labour

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