“…Young people who inject drugs (PWID) frequently experience mental health problems, including mood, anxiety, and personality disorders, as well as alcohol and other substance use disorders (Brooner, King, Kidorf, Schmidt, & Bigelow, 1997; Callaly, Trauer, Munro, & Whelan, 2001; Kessler, 2004; Kessler et al, 2005; Mackesy-Amiti, Donenberg, & Ouellet, 2012; Mason et al, 1998; Teesson et al, 2005). A number of studies with methadone maintenance or other drug treatment patients (Camacho, Brown, & Simpson, 1996; Kleinman et al, 1994; Malow, Corrigan, Pena, Calkins, & Bannister, 1992; Metzger et al, 1991; Perdue, Hagan, Thiede, & Valleroy, 2003; Pilowsky, Wu, Burchett, Blazer, & Ling, 2011; Woody, Metzger, Navaline, McLellan, & O’Brien, 1997), and drug users not in treatment (Johnson, Brems, Wells, Theno, & Fisher, 2003; Johnson, Yep, Brems, Theno, & Fisher, 2002; Simpson, Knight, & Ray, 1993; Strathdee et al, 1997), including syringe exchange program participants (Kidorf et al, 2010), have found that symptoms of psychological distress or dysfunction, particularly symptoms of depression, are associated with injection risk behavior, including sharing syringes and other equipment, number of sharing partners, sharing with strangers, and sharing with a person known to be HIV-positive.…”