Mood and Behavioral Effects of Physostigmine on Humans Are Accompanied by Elevations in Plasma ??-Endorphin and Cortisol

Risch, S. Craig; Rm, Cohen; Janowsky, David S.; Kalin, Ned H.; Murphy, D L; Brown, Burnell R.

doi:10.1097/00132586-198110000-00012

Cited by 8 publications

(10 citation statements)

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“…These results have been replicated in another study . The findings of a 'depressive effect' of physostigmine are consistent with results of other research groups who found that physostigmine leads to a significantly increased plasma cortisol secretion (Risch et al, 1980) and to an escape from dexamethasone suppression, typical of 'endogenous depression' (Carrol1 et al, 1978). These results seem to suggest that there is some truth in cholinergicadrenergic balance hypothesis of affective disorders (Janowsky et al, 1972;Fritze and Beckmann, 1988).…”

Section: Biological Similarities Between Dementia Of the Alzheimer Tysupporting

confidence: 89%

Depression and dementia of the alzheimer type: Implications for psychopharmacological research

Siegfried

1989

Human Psychopharmacology

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Section: Biological Similarities Between Dementia Of the Alzheimer Tysupporting

confidence: 89%

Depression and dementia of the alzheimer type: Implications for psychopharmacological research

Siegfried

1989

Human Psychopharmacology

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“…An important component of this is the release of corticotropin-releasing factor from the hypothalamus by acetylcholine, which has been established both in vitro and in vivo. Physostigmine in humans has been shown to elevate the levels of plasma cortisol, prolactin, arginine vasopressin, and growth hormone (34,115,208). The ability of scopolamine, but not methylscopolamine, to blunt these responses and the inability of neostigmine to mimic the actions of physostigmine is consistent with a central mode of action of physostigmine (34,57,115).…”

Section: Other Centrally Mediated Effectsmentioning

confidence: 69%

The Pharmacology of Physostigmine

Triggle

Mitchell

Filler³

1998

CNS Drug Reviews

139

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“…The importance of cholinergic receptors in regulation of the CRF and ACTH secretion in both the isolated rat hypothalamo-pituitary unit in vitro and different species in vivo has been well documented [3, 13,23,25,26]. The lack of effect of atropine on the histamine-or PEA-and dimapritinduced corticosterone secretion in the present experiment, while finding that this drug abolishes the carbachol-induced hormone secretion, suggests that cholinergic muscarinic pathways are not involved in the corticosterone response to centrally administered histamine or Hi-and H2-agonists in stressed rats.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Adrenergic and Cholinergic Antagonists on Central Histaminergic Stimulation of Pituitary-Adrenocortical Response under Stress in Rats

Bugajski¹,

Gadek²

1984

Neuroendocrinology

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A possible interaction of central histaminergic receptors with adrenergic and cholinergic muscarinic neurons in increasing the pituitary-adrenocortical response under stress, assessed indirectly from the corticosterone concentration in blood serum, was investigated in conscious rats. All the drugs were administered intracerebroventriculary, the antagonists 15 to 30 min prior to the agonists. The histamine-induced increase in serum corticosterone levels of stressed rats was considerably antagonized by prazosin, phenoxybenzamine, phentolamine and yohimbine, α₁ and α₂-adrenergic antagonists. These antagonists abolished or significantly attenuated the corticosterone response to 2-pyridylethylamine (PEA), an H₁-receptor agonist, and to dimaprit and 4-methylhistamine(4-MeHA), H₂-receptor agonists. Propranolol, a β-adrenergic blocker, did not substantially change the corticosterone response induced by histamine or histamine H₁- and H₂-receptor agonists. Similarly, atropine was ineffective in blocking the increase in serum corticosterone responses induced by either histamine or PEA and dimaprit in stressed rats. These results suggest that both α₁- and α₂-adrenergic receptors, but not β-adrenergic and cholinergic muscarinic receptors interact with central H₁ and H₂ histaminergic stimulation of the increased pituitary-adrenocortical response in stressed rats.

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Mood and Behavioral Effects of Physostigmine on Humans Are Accompanied by Elevations in Plasma ??-Endorphin and Cortisol

Cited by 8 publications

References 0 publications

Depression and dementia of the alzheimer type: Implications for psychopharmacological research

Depression and dementia of the alzheimer type: Implications for psychopharmacological research

The Pharmacology of Physostigmine

The Effect of Adrenergic and Cholinergic Antagonists on Central Histaminergic Stimulation of Pituitary-Adrenocortical Response under Stress in Rats

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