Montreal Cognitive Assessment (MoCA): Validation study for Frontotemporal Dementia

Freitas, Sandra; Simões, Mário R.; Alves, Lara Bacelar; Duro, Diana; Santana, Isabel

doi:10.1177/0891988712455235

Cited by 83 publications

(61 citation statements)

References 70 publications

(127 reference statements)

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“…6,50 However, in the present study, this was not confirmed for the MMSE in all the study groups and, in what regard to the MoCA, there was a significant, yet weak correlation (a higher correlation exists in MCI group). The absence of a strong correlation between age and the screening tests' scores in our sample can be more substantially due to the smaller size and limited age range of the sample studied (M ¼ 72.78, standard deviation ¼ 7.98; min: 50, max: 91), compared to the other community studies that were conducted with larger samples and participants distributed along a wide age range.…”

Section: Discussioncontrasting

confidence: 88%

“…The present study is also the first to examine the relationship between premorbid intelligence and MoCA. The growing use of the MoCA in everyday practice and research (in several clinical groups as MCI, AD, frontotemporal, and vascular dementia) and its overall superiority in comparison with the MMSE as a global cognitive assessment instrument regarding discriminative validity and diagnostic accuracy 50 justifies the importance of our findings. Our main conclusion is that a single MMSE or MoCA score should not be used to classify a patient as impaired, unless interpreted in the light of original IQ.…”

Section: Discussionmentioning

confidence: 77%

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Premorbid IQ Influence on Screening Tests’ Scores in Healthy Patients and Patients With Cognitive Impairment

Alves

Simões

Martins

et al. 2013

J Geriatr Psychiatry Neurol

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Cognitive screening tests are well-established tools for detecting cognitive impairment, but concerns regarding the influence of premorbid intelligence on patient’s performance and cognitive status classification remain. Risk of inaccurate assessment especially affects the elders with high or low premorbid intelligence (who are more likely to be misclassified). The present study examines the influence of premorbid intelligence assessed by the TeLPI (an irregular words reading test) on 2 cognitive screening tests, the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA), in healthy participants and patients with cognitive impairments (mild cognitive impairment and Alzheimer disease). Results show that premorbid IQ influences the MMSE and the MoCA scores in both the groups, predicting variance from 8.4% to 33.2%, according to test and group analyzed. Hence, we propose that whenever the MMSE or the MoCA is used, premorbid IQ evaluation should also be considered to ensure correct interpretation and classification.

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Section: Discussioncontrasting

confidence: 88%

Section: Discussionmentioning

confidence: 77%

Premorbid IQ Influence on Screening Tests’ Scores in Healthy Patients and Patients With Cognitive Impairment

Alves

Simões

Martins

et al. 2013

J Geriatr Psychiatry Neurol

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“…De acordo com estes resultados, propuseram dados normativos considerando essas duas variáveis (Anexo 1 -http://www.actamedicaportuguesa.com/revista/ index.php/amp/editor/downloadFile/6889/19736). Paralelamente, o mesmo grupo desenvolveu estudos de validação do MMSE num centro terciário, abrangendo os principais grupos nosológicos de défice cognitivo e demência: défice cognitivo ligeiro (DCL) e doença de Alzheimer (DA), 15 demência frontotemporal (DFT) 16 , demência vascular (DV) 17 e demência com corpos de Lewy (DCLewy). 18 A pontuação de corte mais favorável para o DCL foi o valor de 29, correspondendo-lhe valores de sensibilidade 67%, de especificidade 72% e acuidade diagnóstica de 69%.…”

Section: Introductionunclassified

Mini-Mental State Examination: Avaliação dos Novos Dados Normativos no Rastreio e Diagnóstico do Défice Cognitivo

et al. 2016

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RESUMOIntrodução: O Mini-Mental State Examination é o teste de rastreio de défice cognitivo/demência mais difundido. No nosso país têm-se utilizado pontuações de corte definidas por grupos de literacia, mas existem novas propostas sustentadas por estudos mais representativos. Propomo-nos confirmar a influência da idade e da escolaridade no desempenho, avaliar a capacidade discriminativa dos novos dados normativos e testar a acuidade diagnóstica das pontuações de corte validadas para o défice cognitivo ligeiro e para as formas mais prevalentes de demência. The Mini-Mental State Examination is the most commonly used cognitive screening test. In Portugal, the cut-off scores are defined according to literacy groups, but different proposals have been recommended by more representative studies. We therefore propose to confirm the influence of demographical variables, such as age and education, in the subject's performance; evaluating the discriminant ability of the new normative data; and to further examine the diagnostic acuity of the validated cut-off scoring for mild cognitive impairment and for the most prevalent types of dementia. Material and Methods: Our study includes 1 441 educated subjects, divided into seven subgroups: Mild cognitive impairment, Alzheimer's disease, frontotemporal dementia, vascular dementia, dementia with Lewy bodies, community-controls and memory cliniccontrols. Results: Altogether age and education explain 10.4% of the Mini-Mental State Examination results variance, with both variables contributing significantly to the results' prediction. The diagnostic acuity based on the most recent normative data was always higher than the one obtained through the validation cut-off scoring, revealing an overall excellent specificity (superior to 90%) and different sensitivity values: excellent for mild Alzheimer's disease (91%), good for dementia with Lewy Bodies (78%) and low for mild cognitive impairment (65%), frontotemporal dementia and vascular dementia (55%). Discussion and Conclusions:The performance on the Mini-Mental State Examination is influenced by age and education, supporting the use of normative data that consider those variables. With this approach, the Mini-Mental State Examination could be a sensitive and specific instrument for the Alzheimer's disease screening among all healthcare levels. Nevertheless, its diagnostic acuity is limited in other conditions frequently seen in memory clinics, such as Mild Cognitive Impairment and other types of dementia.

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“…Presently, MMSE is still widely used in national and international research and represents a common reference in the communication between health professionals, including psychologists, neurologists, and psychiatrists (Mitchell, 2009;Nieuwenhuis-Mark, 2010). Despite the limitations currently pointed out in the literature (Freitas, Simões, Alves, & Santana, 2013;Naugle & Kawczak, 1989;Wind et al, 1997) to the MMSE as a cognitive screening test for the mildest stages of cognitive decline, the value of this analysis for the evaluation of moderate to severe dementia cases has been demonstrated (Freitas et al, 2013;Harvan & Cotter, 2006;O'Bryant, et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

The Relevance of Sociodemographic and Health Variables on MMSE Normative Data

Freitas

Simões

Alves

et al. 2014

Applied Neuropsychology: Adult

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The Mini-Mental State Examination (MMSE) is the most broadly used cognitive screening instrument in clinical and research contexts. The MMSE was administered to a community-based sample of cognitively healthy adults (n=850), stratified according to several sociodemographic variables, with a distribution similar to that observed in the Portuguese population. This study aimed to analyse the influence of sociodemographic (age, gender, educational level, marital and employment status, geographic region, geographic localisation, and residence area) and health variables (subjective memory complaints of the participant and evaluated by the informant, depressive symptoms and family history of dementia) on the subjects' performance on the MMSE and to establish normative data for the Portuguese population. Educational level and age significantly contributed to the prediction of the MMSE scores, explaining 26% of its variance.Regarding health variables, only the subjective memory complaints of the participant showed a small contribution (4%) to the variance of the MMSE scores. According to these results, age and education were considered in the development of the normative data of the MMSE for the Portuguese population.

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Montreal Cognitive Assessment (MoCA): Validation study for Frontotemporal Dementia

Cited by 83 publications

References 70 publications

Premorbid IQ Influence on Screening Tests’ Scores in Healthy Patients and Patients With Cognitive Impairment

Premorbid IQ Influence on Screening Tests’ Scores in Healthy Patients and Patients With Cognitive Impairment

Mini-Mental State Examination: Avaliação dos Novos Dados Normativos no Rastreio e Diagnóstico do Défice Cognitivo

The Relevance of Sociodemographic and Health Variables on MMSE Normative Data

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