Month of birth and grass pollen or mite sensitization in children with respiratory allergy: a significant relationship

Businco, L; Cantani, A; Farinella, F.; Businco, E

doi:10.1111/j.1365-2222.1988.tb02869.x

Cited by 66 publications

(43 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Scandinavia, birch pollen is an important aller gen; infants born between February and April (the birch pollen season is in May) are at greatest risk of sensitisa tion to birch pollen [6], Similarly, with allergens arising from plants pollinating later in the year, grass pollen and mugwort, an increased risk of sensitisation is seen in those born between April and May [7], A similar finding is described in relationship to house dust mite [8]. It is inter esting that the intensity of exposure influences the risk of sensitisation, and that the month-of-birth effect can still be measured in a 20-to 29-year-old age group [6,7], Another important allergen exposure, that to domestic pets, has been shown to demonstrate a similar phenome non.…”

Section: Allergic Diseasessupporting

confidence: 51%

Immune Respiratory Disease Associated with the Inadequate Control of Indoor Air Quality

Pickering¹

1992

Indoor Built Environ

View full text Add to dashboard Cite

The prevalence of immunologically determined respiratory diseases is increasing throughout the world and this has been associated with an increased mortality from bronchial asthma. Consequently, there has been considerable interest in the factors that may influence the development of allergic disorders. The first few weeks following birth have been identified as important in determining the development of sensitivity to airborne allergens and subsequent allergic respiratory disorders. The expression of allergic diseases is both genetically determined and influenced to a significant degree by environmental factors related to indoor air quality. As well as possibly initiating allergic disease in the post-natal period, poor indoor air quality may cause respiratory disease in later life. These diseases may be allergic in origin (bronchial asthma or allergic alveolitis) or may be due to infections (Legionnaires’ disease). The contamination of indoor air by micro-organisms may occur from the structure of the building, the ventilation system or be introduced into the building from the outside air. The off-gassing of chemicals within buildings has attracted considerable attention over the past few years, but the evidence that this process can cause immunological disease in man is very limited. It is concluded that indoor air quality is an important potential cause of immunological respiratory disease in man which has been and still is frequently neglected.

show abstract

Section: Allergic Diseasessupporting

confidence: 51%

Immune Respiratory Disease Associated with the Inadequate Control of Indoor Air Quality

Pickering¹

1992

Indoor Built Environ

View full text Add to dashboard Cite

show abstract

“…Subsequently a significantly higher incidence of sensitization to pollens in childrens born in the March-May period and to mites in children born in the September-October period has been shown by several investigators. However, other studies have failed to confirm the above results [24].…”

Section: Prenatal Factorsmentioning

confidence: 39%

“…We showed that a significantly high proportion of children born during the June-September period had a Dermatophagoides pteronyssinus allergy (p < 0.005), while those born during the March-May period had a grass-pollen sensitivity ( p << 0.005 ), in the Rome province for the same age period of the children examined [24].…”

Section: Prenatal Factorsmentioning

confidence: 73%

In 2532 Children we Report the Developmental Factors Influencing the Development of Atopic Diseases

Cantani¹

2017

Austin J Allergy

View full text Add to dashboard Cite

Allergic asthma and rhinitis, Atopic Dermatitis (AD), urticaria and gastrointestinal allergy, are common diseases of infants and children. It was recently estimated that 14% of children suffer from AD, 8% from food allergy, and 12% from asthma [1,2]. The cumulated incidence of these diseases in adolescents has been estimated between 25-35%, while the prevalence is about 20% [3]. The phenotypic expression of these illnesses varies extensively, being very mild in some cases, severe in many, and even life threatening in others. Specific IgE antibodies to foods and positive challenge tests to a number of food allergens are frequently present in children with these disorders. Cow's Milk (CM) appears to be the most common offending food both in gastrointestinal (vomiting, diarrhea, etc) and in cutaneous manifestations (urticaria and AD). About 0.5-7% of infants suffer from more or less adverse reactions to CM [4]. Babies particularly of atopic parents are at high risk of developing atopic diseases; therefore they are defined as at-risk babies [5][6][7].conditions. It has been known for centuries that heredity plays an important role in the development of atopy. A child with a negative family history still has about a 5-15% risk of developing atopy. However, children with a parental history of atopic disease are at higher risk for the development of atopic symptoms. It has been found that if one parent is affected, the chances of an offspring being affected vary between 20 and 40%. If both parents are affected the figure increases up to 40-60%, and 50-80% if both show the same allergic manifestations. The risk of atopy in children who have an allergic sibling ranges between 25 and 35% [3,10].The importance of genetic factors is also demonstrated by other data:(I) children with positive family history for atopy develop allergic symptoms earlier than those with a negative family history [11], (II) The higher the incidence the higher the number of affected subjects in the same family [3].Notable differences exist in the so-called predisposition to atopic diseases, and further study appears to be necessary to better delineate the role played by genetic factors in the development of such disorders.In many allergic patients total serum IgE levels are found to be elevated, and it has been shown that a high total serum IgE level in infants is often associated with the subsequent development of atopic symptoms. Therefore, it was proposed that the measurement of IgE by PRIST testing in infants or at birth would have a predictive value in the atopy development. Several investigators have demonstrated that the risk of developing atopic diseases was very high when the cord IgE level was above 0.5 IU/ml [5,8,9,12].Our data shows that a newborn can be considered at risk for atopy when the cord IgE level is above 0.8 IU/ml [5]. We have also shown that neonates of non atopic parents (0.032 + 0

show abstract

“…This finding has important implications for vaccinology, because it implies that the Th1-type responses required for the resolution of intracellular infections could be impaired during early life. In relation to allergic diseases, it implies the existence of a temporal window in the early postnatal period when children may have an enhanced risk for primary Th2-polarized immunological memory against environmental allergens, a possibility supported by a wide body of epidemiological evidence (17)(18)(19).…”

Section: Adjuvant Costimulation During Secondary Antigen Challenge DImentioning

confidence: 99%

Adjuvant Costimulation during Secondary Antigen Challenge Directs Qualitative Aspects of Oral Tolerance Induction, Particularly during the Neonatal Period

Tobagus

Thomas

Holt

2004

The Journal of Immunology

View full text Add to dashboard Cite

In this report we demonstrate that although passive feeding of specific Ag to mice as neonates or adults can induce oral tolerance in both the cellular and humoral arms of the immune response, quantitative and, in particular, qualitative aspects of the tolerance process are determined by the nature of the inflammatory costimuli provided at the time of secondary Ag challenge. Moreover, this dependency upon nonspecific costimulation is more profound in Ag-fed neonates than in their adult counterparts. Thus, administration of Ag in the Th1-selective adjuvant CFA to prefed animals resulted in significant inhibition of IgG2a, IL-2, and IFN-γ responses, whereas IL-5 responses were increased. In contrast, rechallenge with Ag in the Th2-selective adjuvant aluminum hydroxide resulted in significant inhibition of IgG1, IgE, IL-2, and IL-5 responses, whereas IFN-γ responses were increased. Additionally, although soluble Ag challenge of prefed adults revealed marginal tolerogenic effects, the same challenge protocol in animals prefed as neonates elicited enhanced Th2-dependent IgG1 production. These results suggest that inflammatory stimulation at the time of Ag challenge is obligatory to trigger oral tolerance mechanisms, particularly in animals fed as neonates and also that the type of adjuvant used at the time of challenge selects for the type of Th cell population to be inhibited.

show abstract

Month of birth and grass pollen or mite sensitization in children with respiratory allergy: a significant relationship

Cited by 66 publications

References 13 publications

Immune Respiratory Disease Associated with the Inadequate Control of Indoor Air Quality

Immune Respiratory Disease Associated with the Inadequate Control of Indoor Air Quality

In 2532 Children we Report the Developmental Factors Influencing the Development of Atopic Diseases

Adjuvant Costimulation during Secondary Antigen Challenge Directs Qualitative Aspects of Oral Tolerance Induction, Particularly during the Neonatal Period

Contact Info

Product

Resources

About