Montelukast with desloratadine or levocetirizine for the treatment of persistent allergic rhinitis

Quality of life in patients with persistent allergic rhinitis treated with desloratadine monotherapy or desloratadine plus montelucast combination

“…Their study showed that combination therapy with montelukast and an antihistamine may have a positive impact on persistent allergic rhinitis and improve quality of life and nighttime symptoms. [31] The improvement in nasal symptoms, eye symptoms, practical problems and activity limitations were nearly the same in patients treated with desloratadine and desloratadine plus montelukast combination therapy. Sleep symptom scores significantly decreased in patients treated with desloratadine plus montelukast combination therapy.…”

“…Ciebiada et al [31] demonstrated that montelukast was as efficacious in the improvement of nasal congestion as desloratadine or levocetirizine, and that it was more efficacious than placebo. Furthermore, combination therapy was more effective than monotherapy with montelukast alone and more effective than monotherapy with montelukast or desloratadine.…”

Montelukast: Pharmacology, Safety, Tolerability and Efficacy

“…44 In patients with persistent AR, the combination of montelukast and either desloratadine or levocetirizine were more effective than monotherapy with either of these three medications. 56 In children 2-6 years old, montelukast was equivalent to cetirizine in the management of nasal symptoms of perennial AR except for nasal itching which was better controlled with cetirizine. 43 Montelukast in combination with cetirizine showed better control of the clinical nasal symptoms and reduced eosinophil counts better than either montelukast or cetirizine alone in seasonal AR patients.…”

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions

“…Other studies indicate that LTRAs can alleviate the signs and symptoms of AR when used either as monotherapy (van Adelsberg et al, 2003;Lee et al, 2004b;Ho and Tan, 2007;Wahn and Dass, 2008;Diamant et al, 2009;Cingi and Ozlugedik, 2010) or in combination with an antihistamine in adults (Meltzer et al, 2000;Nayak et al, 2002;Ciprandi et al, 2004;Kurowski et al, 2004;Ciebiada et al, 2006;Lagos and Marshall, 2007;Li et al, 2009), as well as in children (Phan et al, 2009). Results from meta-analyses indicate that antihistamines and LTRAs are equally effective in improving symptoms of AR and QL, but that both drugs are less effective than intranasal corticosteroids (Pullerits et al, 2002;Saengpanich et al, 2003;Di Lorenzo et al, 2004b;Wilson et al, 2004;Rodrigo and Yañ ez, 2006;Van Hoecke et al, 2007).…”