Montelukast in Allergic Rhinitis: A Review

“…These donor atoms coordinate with the metal ion forming dative bonds, modifying its steric and electronic environment as well as its reactivity. [17] Therefore, Schiff bases have a variable denticity, classified according to the number of donor atoms as monodentate, [18] bidentate, [19] tridentate, [20] tetradentate, [21] pentadentate, [22] hexadentate [23] ligands, among others. Schiff bases have gained medical importance for their versatile applications in the treatment of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

et al. 2022

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Although it is known that the first case of cancer was recorded in ancient Egypt around 1600 BC, it was not until 1917 during the First World War and the development of mustard gas that chemotherapy against cancer became relevant; however, its properties were not recognised until 1946 to later be used in patients. In this sense, the use of metallopharmaceuticals in cancer therapy was extensively explored until the 1960s with the discovery of cisplatin and its anticancer activity. From that date to the present, the search for more effective, more selective metallodrugs with fewer side effects has been an area of continuous exploration. Efforts have led to considering a wide variety of metals from the periodic table, mainly from the d-block, as well as a wide variety of organic ligands, preferably with proven biological activity. In this sense, various research groups have found an ideal binder in Schiff bases, since their raw materials are easily accessible, their synthesis conditions are friendly and their denticity can be manipulated. Therefore, in this review, we have explored the anticancer and antitumor activity reported in the literature for coordination complexes of d-block metals coordinated with tridentate Schiff bases (O N O and O N N) derived from salicylaldehyde. For this work, we have used the main scientific databases CCDC® and SciFinder®.

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“…The 1 H NMR spectrum of the intermediate (I)aredepicted in Fig.3. The 13 C NMR of dial derivative (I) exhibits a sharp peak at 78 ppm with 70% intensity which has been assigned to the methylenic carbons, the sharp peak of weak intensity observed at 192 ppm has been assigned to aldehydic carbon and the medium intensity peaks centered around 112-138 ppm has been attributed to the aromatic carbon atoms pertaining to benzene and naphthalene moieties 25 . The 13 C NMR spectrum of the intermediate (I) are depicted in Fig.4 The 1 H NMR spectrum of the ligand (L) exhibits a multiplet around 7.1 ppm to 8.1 ppm assignable to the aromatic protons of Napthaldehyde and benzene groups, the singlet of medium intensity occurring at 9.4 ppm has been assigned to azomethine protons in the macrocycle.…”

Section: Synthesis Of Dialdehydementioning

confidence: 99%

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2016

IJPSR

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ABSTRACT:An -12,14,16, 18,20,22, 24,26,28,30,32,34,36,38,40-pentadecaene, has been synthesized by two different synthetic routes each involving two stages. 2-Hydroxy-1-Napthaldehyde in the presence of potassium carbonate was treated with α,α'-dibromo-o-xylene to yield the dial derivative(I). The dial derivative(I) was further made to undergo Schiff base condensation with 1,2-diaminobenzene to yield the bright yellow macrocycle (L) in good yield. In the second method the Schiff base condensed product Napthaloph was synthesized and allowed to undergo ). The complexes were also synthesized by the metal template method. The yield of the template procedure was found to be greater than the non-template method. The ligand and the complexes were characterized by elemental analysis, electronic spectroscopy, IR, Conductivity measurements, EPR, magnetic susceptibility, 1 HNMR, FAB-MS and Cyclic voltammetry studies. The [16]-membered tetradentate dioxadiaza macrocycle (L) was found to accommodate Co 3+ , Ni 2+ , and Cu 2+ ions with ease due to the presence of flexible alkyl groups. Further studies with the inner-transition metal ions will be highly informative in understanding the coordinating capabilities of lanthanides and actinides.

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Montelukast in Allergic Rhinitis: A Review

Abstract: Abstract

Cited by 5 publications

References 16 publications

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Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

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