Montelukast improves pulmonary function measured by impulse oscillometry in children with asthma (Mio study)

Nieto, Antonio; Pamies, Rafael; Oliver, F. E.; Medina, Alejandra; Caballero, Luis; Mazon, Angel

doi:10.1016/j.rmed.2005.10.025

Cited by 53 publications

(34 citation statements)

References 32 publications

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“…Treatment with montelukast resulted in improvement in FEV1 and in specific conductance; improvement in asthma symptoms was also observed and was correlated with improvement in residual volume. In children, montelukast was also shown to improve measurements assessing distal airway obstruction [139,140].…”

Section: Treatments Targeting Distal Airways In Asthma: Clinical Studiesmentioning

confidence: 99%

Update on the roles of distal airways in asthma

Burgel¹,

Blic²,

Chanez³

et al. 2009

European Respiratory Review

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The present review is the summary of an expert workshop that took place in Vence (France) in 2007 on the role of distal airways in asthma. The evidence showing inflammation and remodelling in distal airways, and their possible involvement in asthma control and natural history, was reviewed. The usefulness and limitations of various techniques used for assessing distal airways were also evaluated, including pulmonary function tests and imaging. Finally, the available data studying the benefit of treatment better targeting distal airways in asthma was examined. It was concluded that both proximal and distal airways were involved in asthma and that distal airways were the major determinant of airflow obstruction. Inflammation in distal airways appeared more intense in severe and uncontrolled asthma. Distal airways were poorly attained by conventional aerosol of asthma medications owing to their granulometry, being composed of 3-5 mm particles. Both proximal and distal airways might be targeted either by delivering medications systemically or by aerosol of extra-fine particles. Extra-fine aerosols of long-acting b-agonists, inhaled corticosteroids or inhaled corticosteroid/long-acting b-agonist combinations have been shown in short-term studies to be not inferior to non-extra-fine aerosols of comparators. However, available studies have not yet demonstrated that extra-fine inhaled medications offer increased benefit compared with usual aerosols in asthmatic patients.

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Section: Treatments Targeting Distal Airways In Asthma: Clinical Studiesmentioning

confidence: 99%

Update on the roles of distal airways in asthma

Burgel¹,

Blic²,

Chanez³

et al. 2009

European Respiratory Review

View full text Add to dashboard Cite

show abstract

“…23 We used resistance at 5 Hz (R 5 ), 20 Hz (R 20 ), frequency dependence (R [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] ) as indicators of total, large, and small airway resistance, respectively; reactance at 5 Hz (X 5 ) was used as an index of the reactance of the overall respiratory system. [23][24][25][26] We also measured resonant frequency (F res ) and integrated area of low-frequency X (AX) as a sensitive measure of small airways obstruction. [24][25][26] Allergy Skin Test Participants were tested with five common allergens, which could be persistent with the workplace: house dust mite (Dermatophagoides pteronyssinus), mixed grass pollen, Cladosporium sp, cat and dog, along with glycerol-saline and histamine controls (Bayer, Elkert, Ind).…”

Section: R T I C L E a R T I C L Ementioning

confidence: 99%

“…[23][24][25][26] We also measured resonant frequency (F res ) and integrated area of low-frequency X (AX) as a sensitive measure of small airways obstruction. [24][25][26] Allergy Skin Test Participants were tested with five common allergens, which could be persistent with the workplace: house dust mite (Dermatophagoides pteronyssinus), mixed grass pollen, Cladosporium sp, cat and dog, along with glycerol-saline and histamine controls (Bayer, Elkert, Ind). Droplets of allergens as well as positive and negative controls were applied to the flexor surface of the forearm; the reactions were recorded after 15 min.…”

Section: R T I C L E a R T I C L Ementioning

confidence: 99%

Respiratory Morbidity among Indian Tea Industry Workers

Moitra

Thapa

Das

et al. 2016

Int J Occup Environ Med

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“…Os ARLT têm demonstrado efeitos opostos aos dos LT: melhoram a obstrução das vias aéreas periféricas avaliada por volumes pulmonares, aprisionamento de ar (air trapping) 16 , resistência das vias aéreas, condutância específica 17 e oscilometria 18 . Diminuem o número de eosinófilos no escarro induzido 19 e no sangue periférico de pacientes asmáticos 20 .…”

Section: O Que São E Como Agem Os Leucotrienos (Lt) E Os Antagonistasunclassified

Antileukotrienes in the treatment of asthma and allergic rhinitis

Ribeiro¹,

Toro²,

Baracat³

2006

J Pediatr (Rio J)

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Objective: To compare leukotriene antagonists (LTA) to other groups of drugs used in asthma and allergic rhinitis treatment.Sources: MEDLINE, LILACS and Cochrane Library. Keywords: leukotrienes, antileukotrienes, asthma treatment, allergic rhinitis treatment, asthma and allergic rhinitis. An attempt was made to group the main studies and reviews about this topic Summary of the findings: LTA are more efficient than placebo and enhance the effects of inhaled corticosteroids. The association of inhaled corticosteroids with long-acting ß2 agonists is more efficient than the association of inhaled corticosteroids + LTA. Although use of LTA in acute asthma attacks and allergic rhinitis seems reasonable, more studies are needed to confirm this benefit. LTA reduce hospitalization time and the number of wheezing attacks in infants with acute viral bronchiolitis caused by respiratory syncytial virus, as well as recurrent wheezing after acute viral bronchiolitis. LTA are less efficient than intranasal corticosteroids for allergic rhinitis management. LTA are efficient in exercise-induced asthma, although they are not the first-line treatment. Conclusion:Controlled and randomized studies show that inhaled corticosteroids are the drugs of choice to treat persistent asthma and allergic rhinitis. There is not enough evidence to recommend the use of LTA as first-line drug (monotherapy) in children with asthma (level I). For children who cannot use inhaled corticosteroids, LTA may be a good alternative (level II).J Pediatr (Rio J). 2006;82(5 Suppl):S213-21: Asthma, exerciseinduced asthma, rhinitis, antileukotrienes, montelukast, zafirlukast. ResumoObjetivo: Comparar os antagonistas de leucotrienos (ARLT) aos outros grupos de medicamentos utilizados para tratar a asma e a rinite alérgica.Fontes dos dados: MEDLINE, LILACS e Biblioteca Cochrane. Palavras chaves: leucotrienos, antileucotrienos, tratamento da asma, tratamento da rinite alérgica, asma e rinite alérgica. Procurou-se agrupar os principais trabalhos e revisões sobre o assunto.Síntese dos dados: Os ARLT são mais eficazes do que placebo e potencializam os efeitos dos corticosteróides inalados. A associação de corticosteróides inalados com agentes ß2-agonistas de longa duração (LABA) é mais eficaz do que a associação de cortiscoteróides inalados + ARLT. Embora pareça racional o uso de ARLT na crise aguda de asma e rinite alérgica, mais estudos são necessários para comprovar esse benefício. Os ARLT promovem redução no tempo de hospitalização e no número de crises de sibilância em lactentes com bronquiolite viral aguda pelo vírus respiratório sincicial e na sibilância recorrente após bronquiolite viral aguda. Os ARLT são menos eficazes que os corticosteróides intranasais no manejo da rinite alérgica. Os ARLT são eficazes na asma induzida por exercício (AIE), embora não constituam a primeira linha de tratamento. Conclusão:Estudos controlados e randomizados mostram que os corticosteróides inalados são as drogas de escolha para o tratamento da asma persistente e rinite a...

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Montelukast improves pulmonary function measured by impulse oscillometry in children with asthma (Mio study)

Abstract: Montelukast improves central and especially peripheral airways function in the first month of treatment, as evaluated by IOS, a technique based on tidal breathing analysis which is more sensitive than conventional forced spirometry.

Cited by 53 publications

References 32 publications

Update on the roles of distal airways in asthma

Update on the roles of distal airways in asthma

Respiratory Morbidity among Indian Tea Industry Workers

Antileukotrienes in the treatment of asthma and allergic rhinitis

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