“…Monte Carlo simulations provide flexibility in the design of phantom and irradiation systems, which are either very expensive or exceptionally complex and demanding to setup experimentally (Kalender 1981, Chan and Doi 1982, Dance and Day 1984, Barnea and Dick 1986, Boone and Seibert 1988, Boone et al 2000b, Boone et al 2002a, Saunders and Samei 2006, Ullman et al 2006, Ghafarain et al 2007, Al Kafi et al 2009, Cunha et al 2010, Sisniega et al 2013. Monte Carlo simulations also have the advantage of being able to replicate clinical situations and allow validation of technologies before implementation (Chan and Doi 1983, Nikolopoulos et al 2007, Salvat et al 2008, Myronakis et al 2013, Del Lama et al 2016. For example, a commonly used Monte Carlo simulation is PENELOPE (Penetration and energy loss of positrons and electrons), which uses the FORTRAN computer language and has a set of subroutines which perform simulations of electron-photon coupled transport for a wide energy range in arbitrary materials and geometries (Sempau et al 2001, Sempau et al 2003, Salvat et al 2011.…”