Monte Carlo simulations and phantom validation of low-dose radiotherapy to the lungs using an interventional radiology C-arm fluoroscope

Roa, D; Leon, Stephanie; Páucar, Oliver; Gonzales, Andres; Olguin, Edmond A.; Moskvin, V.; Alva-Sánchez, Mirko Salomón; Glassell, Megan; Correa, Nathalie; Moyses, Harry; Li, B; Tajima, T.; Nečas, Aleš; Guzman, Carmen; Challco, Roger; Montoya, M.; Meza, Z. M. Arqque; Zapata, MartÃ­n Cadena; Marquez, Felicia M.; Neira, Rodrigo; Vilca, Walter; Méndez, Juan Antonio Juanes; Hernandez, Juan

doi:10.1016/j.ejmp.2021.12.014

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Unlike the high energy applications of LWFA and beam-driven wakefield accelerators, these medical radiotherapy applications look at the non-relativistic regime of the laser (the normalized laser strength parameter a 0 ¡1). Some of the researchers in medical radiation oncologists called for a departure from the traditional radiation therapy of cancer and even COVID such as Brachy therapy, due to the safety, convenience, and more accurate targeting of radiation [26,27,28]. In low energy electron therapy (such as 10's keV ) in some of these therapies (including the surface skin tumor treatments) the electron acceleration is very local using non-relativistic laser intensity [26].…”

Section: Crystal Channeling Muon Linear Collider Design Principlesmentioning

confidence: 99%

Channeling Acceleration in Crystals and Nanostructures and Studies of Solid Plasmas: New Opportunities

Ariniello¹,

Corde²,

Davoine³

et al. 2022

Preprint

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Recently started E336 collaboration will study excitation of transverse and longitudinal wakefields by an ultra-dense FACET-II electron bunch in evacuated channels such as stacks of CNTs or micron-or submicron channel arrays in O(1 mm) long dielectric targets. PIC simulations indicate that even with the micron-scale FACET-II bunches that extend over many nano-or micro-tubes, the PWA effects will result in beam nanomodulation and an easily detectable expansion of the angular spread of the 10-GeV beam electrons, far exceeding that from just a multiple scattering process. Next phase of the E336 experiments will study formation of the beam nano-bunches in the solid plasma, observation of the betatron radiation, and, eventually, particle acceleration by ultra-strong longitudinal wakefields.Required also is an in-depth research on dynamics of beam-plasma instabilities in ultradense plasma, its development and suppression in structured media like CNTs and crystals, and its potential use as a pre-modulator or as an amplifier for easier detection of the imprint of the nanostructure on the beam in E336 experiment. The recent invention of the thin film compression technique opens the way to introduce the availability of the singlecycled laser pulse and thus the relativistic compressed X-ray laser pulse, which fits the need for X-ray-driven nanostructure PWA. Given the tremendous promise of the crystal/CNT channeling acceleration and the not-yet fully explored complexity of the beam, laser and plasma physics involved in corresponding phenomena at the nanometer scales, exploration of promising near-term applications, serious theoretical analysis, and advanced computer

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Section: Crystal Channeling Muon Linear Collider Design Principlesmentioning

confidence: 99%

Channeling Acceleration in Crystals and Nanostructures and Studies of Solid Plasmas: New Opportunities

Ariniello¹,

Corde²,

Davoine³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Such electrons may be used to address other therapy such as allowing for a handheld radiation therapy device that can directly target superficial skin cancers such as melanoma [25][26][27][28]. Further, we could also employ a vector medicine (with high Z) that can guide itself toward the targeted tissue (such as cancer cells) that attracts and absorbs electrons preferentially to the vector molecules with its high Z distinction [29].…”

Section: Applications To Medicinementioning

confidence: 99%

Laser Beat-Wave Acceleration near Critical Density

et al. 2022

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We consider high-density laser wakefield acceleration (LWFA) in the nonrelativistic regime of the laser. In place of an ultrashort laser pulse, we can excite wakefields via the Laser Beat Wave (BW) that accesses this near-critical density regime. Here, we use 1D Particle-in-Cell (PIC) simulations to study BW acceleration using two co-propagating lasers in a near-critical density material. We show that BW acceleration near the critical density allows for acceleration of electrons to greater than keV energies at far smaller intensities, such as 1014 W/cm2, through the low phase velocity dynamics of wakefields that are excited in this scheme. Near-critical density laser BW acceleration has many potential applications including high-dose radiation therapy.

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Low-dose radiotherapy to the lungs using an interventional radiology C-arm fluoroscope: Monte Carlo treatment planning and dose measurements in a postmortem subject

Leon¹,

Páucar²,

Correa³

et al. 2022

Biomed. Phys. Eng. Express

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Objective: The goal of this study was to use Monte Carlo (MC) simulations and measurements to investigate the dosimetric suitability of an interventional radiology (IR) c-arm fluoroscope to deliver low-dose radiotherapy to the lungs. Approach: A previously-validated MC model of an IR fluoroscope was used to calculate the dose distributions in a COVID-19-infected patient, 20 non-infected patients of varying sizes, and a postmortem subject. Dose distributions for PA, AP/PA, 3-field and 4-field treatments irradiating 95% of the lungs to a 0.5 Gy dose were calculated. An algorithm was created to calculate skin entrance dose as a function of patient thickness for treatment planning purposes. Treatments were experimentally validated in a postmortem subject by using implanted dosimeters to capture organ doses. Main Results: Mean doses to the left/right lungs for the COVID-19 CT data were 1.2/1.3 Gy, 0.8/0.9 Gy, 0.8/0.8 Gy and 0.6/0.6 Gy for the PA, AP/PA, 3-field, and 4-field configurations, respectively. Skin dose toxicity was the highest probability for the PA and lowest for the 4-field configuration. Dose to the heart slightly exceeded the ICRP tolerance; all other organ doses were below published tolerances. The AP/PA configuration provided the best fit for entrance skin dose as a function of patient thickness (R2 = 0.8). The average dose difference between simulation and measurement in the postmortem subject was 0.7%. Significance: An IR fluoroscope should be capable of delivering low-dose radiotherapy to the lungs with tolerable collateral dose to nearby organs.

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Monte Carlo simulations and phantom validation of low-dose radiotherapy to the lungs using an interventional radiology C-arm fluoroscope

Cited by 3 publications

References 28 publications

Channeling Acceleration in Crystals and Nanostructures and Studies of Solid Plasmas: New Opportunities

Channeling Acceleration in Crystals and Nanostructures and Studies of Solid Plasmas: New Opportunities

Laser Beat-Wave Acceleration near Critical Density

Low-dose radiotherapy to the lungs using an interventional radiology C-arm fluoroscope: Monte Carlo treatment planning and dose measurements in a postmortem subject

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