Monozygotic twins: genes are not the destiny?

Chatterjee, Aniruddha; Morison, Ian M.

doi:10.6026/97320630007369

Cited by 21 publications

(12 citation statements)

References 18 publications

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“…Although DNA methylation is generally considered to suppress transcription [40], this effect can vary depending on the genomic context, such as position in relation to genes. High DNA methylation in the promoter region is known to generally block transcription initiation or mark already silenced genes [41].…”

Section: Majority Of Thementioning

confidence: 99%

Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended ‘male sex drive’ hypothesis

Chatterjee

Lagisz

Rodger

et al. 2016

Gene

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Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended 'male sex drive ' hypothesis, Gene (2016' hypothesis, Gene ( ), doi: 10.1016' hypothesis, Gene ( /j.gene.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 3 ABSTRACTThe sex drive hypothesis predicts that stronger selection on male traits has resulted in masculinization of the genome. Here we test whether such masculinizing effects can be detected at the level of the transcriptome and methylome in the adult zebrafish brain.Although methylation is globally similar, we identified 914 specific differentially methylated CpGs (DMCs) between males and females (435 were hypermethylated and 479 were hypomethylated in males compared to females). These DMCs were prevalent in gene body, intergenic regions and CpG island shores. We also discovered 15 distinct CpG clusters with striking sex-specific DNA methylation differences. In contrast, at transcriptome level, more female-biased genes than male-biased genes were expressed, giving little support for the male sex drive hypothesis.Our study provides genome-wide methylome and transcriptome assessment and sheds light on sex-specific epigenetic patterns and in zebrafish for the first time.

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Section: Majority Of Thementioning

confidence: 99%

Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended ‘male sex drive’ hypothesis

Chatterjee

Lagisz

Rodger

et al. 2016

Gene

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“…ROP is an abnormal vascular proliferative retinopathy that occurs between 30 and 45 weeks of postgestational age. Its appearance and development are conditioned by the joint action of genetic [ 21 , 22 ], environmental, epigenetic, and random factors [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic and Environmental Influences on Retinopathy of Prematurity

Ortega-Molina

Anaya-Alaminos

Uberos‐Fernández

et al. 2015

Mediators of Inflammation

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Objective. The goals were to isolate and study the genetic susceptibility to retinopathy of prematurity (ROP), as well as the gene-environment interaction established in this disease. Methods. A retrospective study (2000–2014) was performed about the heritability of retinopathy of prematurity in 257 infants who were born at a gestational age of ≤32 weeks. The ROP was studied and treated by a single pediatric ophthalmologist. A binary logistic regression analysis was completed between the presence or absence of ROP and the predictor variables. Results. Data obtained from 38 monozygotic twins, 66 dizygotic twins, and 153 of simple birth were analyzed. The clinical features of the cohorts of monozygotic and dizygotic twins were not significantly different. Genetic factors represented 72.8% of the variability in the stage of ROP, environmental factors 23.08%, and random factors 4.12%. The environmental variables representing the highest risk of ROP were the number of days of tracheal intubation (p < 0.001), postnatal weight gain (p = 0.001), and development of sepsis (p = 0.0014). Conclusion. The heritability of ROP was found to be 0.73. The environmental factors regulate and modify the expression of the genetic code.

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“…Many twin similarities lessen with age, resulting from factors such as divergence of methylation status (Wong et al 2010). Methylation status is, however, unlikely to account for most such MZ twin discordance (Chatterjee & Morison 2011). Overall, such findings show that the MZ-DZ gene research is unduly simplistic and question the generalizability of many results from twin populations.…”

Section: Kenneth John Aitkenmentioning

confidence: 95%

Humans, fruit flies, and automatons

Charney

2012

Behav Brain Sci

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My response is divided into four sections: (1) is devoted to a potpourri of commentaries that are essentially in agreement with the substance of my target article (with one exception); in (2) I address, in response to one of the commentaries, several issues relating to the use of candidate gene association studies in behavior genetics (in particular those proposing a specific G×E interaction); in (3) I provide a detailed response to several defenses of the twin study methodology; and in (4) I conclude with several reflections on that methodology and the conception of human nature it has fostered.

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Monozygotic twins: genes are not the destiny?

Cited by 21 publications

References 18 publications

Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended ‘male sex drive’ hypothesis

Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended ‘male sex drive’ hypothesis

Genetic and Environmental Influences on Retinopathy of Prematurity

Humans, fruit flies, and automatons

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