Monozygotic twinning associated with mechanical assisted hatching

Hershlag, Avner; Paine, T. D.; Cooper, George; Scholl, Gerald M.; Rawlinson, Keith; Kvapil, Georgina

doi:10.1016/s0015-0282(98)00402-6

Cited by 138 publications

(74 citation statements)

References 4 publications

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“…The increasing incidence of monozygotic twins was also stated in a review of 674 transferred embryos that underwent partial zona dissection (PZD). Monozygotic twins were found in eight (1.2%) of them, compared with none of the 559 embryos that were not hatched [83].…”

Section: Potential Risk Of Ahmentioning

confidence: 89%

“…2 Tree diagram for implantation rates in patients with >2 previous IVF failures undergoing assisted hatching versus those with no assisted hatching itself, including lethal damage to the embryo and damage to individual blastomeres with reduction of embryo viability. In addition, artificial manipulation of the ZP has been associated with an increased risk of monozygotic twinning [83,84].…”

Section: Potential Risk Of Ahmentioning

confidence: 99%

“…First, a small narrow opening in the zona pellucida, especially that created by PZD, may trap the hatching blastocyst in a figure 8 shape. Subdivision of the blastocyst may lead to the formation of monozygotic twins [83]. The second reason is premature hatching of the blastomeres, which may result in development of another identical embryo.…”

Section: Potential Risk Of Ahmentioning

confidence: 99%

See 2 more Smart Citations

Assisted hatching in assisted reproduction: a state of the art

Hammadeh

Fischer-Hammadeh

Ali

2010

J Assist Reprod Genet

104

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The World Health Organization estimates that one in six couples experience some delay in conception and an increasing number require treatment by the assisted conception (AC) procedures of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).The implantation rate of embryos resulting from in vitro fertilization cycles is generally less than 20%. The exposure of oocytes and embryos to the artificial conditions of in vitro culture may have negative effects on the embryo's ability to undergo normal hatching, resulting in low rates of implantation following IVF and embryo transfer. Human embryos resulting from superovulation develop more slowly in vitro compared to embryos in vivo, manifest a relatively high degree of cytogenetic abnormalities and undergo cellular fragmentation. Artificially disrupting the zona pellucida is known as assisted hatching (AH) and there is some evidence that embryos that have undergone zona manipulation for assisted hatching tend to implant one day earlier than unhatched embryos. A variety of techniques have since been employed to assist embryo hatching, including partial mechanical zona dissection, zona drilling and zona thinning, making use of acid tyrodes, proteinases, piezon vibrator manipulators and lasers. This review will consider the impact of IVF conditions on zona pellucida physiology, zona hardening, different techniques of assisted hatching, who may benefit from assisted hatching and potential hazards.

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Section: Potential Risk Of Ahmentioning

confidence: 89%

Section: Potential Risk Of Ahmentioning

confidence: 99%

Section: Potential Risk Of Ahmentioning

confidence: 99%

See 1 more Smart Citation

Assisted hatching in assisted reproduction: a state of the art

Hammadeh

Fischer-Hammadeh

Ali

2010

J Assist Reprod Genet

104

View full text Add to dashboard Cite

show abstract

“…Monochorionic multiple pregnancies after fresh embryo transfers [23]. Although the natural rate of monozygotic twins was reported to be 0.42% [24], the frequency after conventional IVF or intracytoplasmic sperm injection has been reported to vary between 1.2% and 8.9% [25][26][27][28][29]. A significant increase in the incidence of monozygotic twin has been also reported after embryo transfer of day 5/6 blastocysts compared with day 2/3 cleavage stage embryos [30].…”

Section: Discussionmentioning

confidence: 99%

Influence of assisted reproductive technology on multiple pregnancy

Matsumoto

2005

Reproductive Immunology and Biology

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“…Comparative studies have documented an increased risk for MZ twinning in ART pregnancies that included assisted hatching (Hershlag et al 1999;Schieve et al 2000), and animal studies have shown that MZ twinning can be induced through mechanical or chemical manipulation of the zona pellucida (Allen and Pashen 1984;Picard et al 1985;Sotomaru et al 1998;Talansky and Gordon 1988).…”

Section: Assisted Reproductive Technologiesmentioning

confidence: 99%

Off to a good start: the influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's health.

Chapin

Robbins

Schieve

et al. 2004

Environ Health Perspect

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The scientific community is developing a compelling body of evidence that shows the importance of the in utero environment (including chemical and hormonal levels) to the ultimate health of the child and even of the aging adult. This article summarizes the evidence that shows this impact begins with conception. Only a full life-cycle evaluation will help us understand these impacts, and only such an understanding will produce logically prioritized mitigation strategies to address the greatest threats first. Clearly, the time for analysis begins when the next generation is but a twinkle in the eye.

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Monozygotic twinning associated with mechanical assisted hatching

Cited by 138 publications

References 4 publications

Assisted hatching in assisted reproduction: a state of the art

Assisted hatching in assisted reproduction: a state of the art

Influence of assisted reproductive technology on multiple pregnancy

Off to a good start: the influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's health.

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