Monounsaturated fatty acids might be key factors in the Mediterranean diet that suppress rheumatoid arthritis disease activity: The TOMORROW study

Matsumoto, Yoshinari; Sugioka, Y.; Tada, Masahiro; Okano, Tadashi; Mamoto, K.; Inui, Kentaro; Habu, Daiki; Koike, Tatsuya

doi:10.1016/j.clnu.2017.02.011

Cited by 69 publications

(61 citation statements)

References 22 publications

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“…The findings in this study are consistent with the findings in these previous reports. In previous reports from Japan, intake of omega3-PUFAs, fish oil and monounsaturated fatty acids might be associated with low disease activity [11,12]. The findings of these reports are consistent with the findings of this study, while the numbers of patients in these reports were smaller than the numbers in this study.…”

Section: Discussionsupporting

confidence: 91%

“…Epidemiological studies focusing on the Japanese diet have been difficult because of the vast variation in Japanese foods [9], although the association between the Japanese diet and lower insulin resistance was reported [10]. There have been few reports in Japan on the association of dietary habits with disease activity and the numbers of patients in those reports were small [11,12]. The purpose of this study is to clarify the relationship between dietary habits of RA patients and their disease activity.…”

Section: Introductionmentioning

confidence: 97%

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Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis

Murakami

Hashimoto

et al. 2020

PLoS ONE

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Objective To clarify the relationship between dietary habit and disease activity of rheumatoid arthritis (RA). Methods This study enrolled RA patients who met the ACR/EULAR 2010 classification criteria from Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort in 2015. 22item food frequency questionnaire (FFQ) was taken for the measurement of dietary habit in a single-institution cohort of RA (Kyoto University Rheumatoid Arthritis Management Alliance: KURAMA) in 2015. The disease activities of RA using the Disease Activity Score calculated based on the erythrocyte sedimentation rate (DAS28-ESR), Simplified Disease Activity Index (SDAI), Health Assessment Questionnaire (HAQ), and serum matrix metalloproteinase-3 (MMP-3) level, the use of disease-modifying anti-rheumatic drugs (DMARDs), disease duration, rheumatoid factor, anti-cyclic citrullinated antibody, and body mass index were also examined. All of them were combined and statistically analyzed. Results 441 RA patients (81% women; mean age 65 years; mean disease duration 15 years) were enrolled from the KURAMA cohort. Average Disease Activity Score-28 using the erythrocyte sedimentation rate (DAS28-ESR) was 2.7. Univariate analysis showed that intake frequency of vegetables had a statistically significant negative correlation with disease activity

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 97%

Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis

Murakami

Hashimoto

et al. 2020

PLoS ONE

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“…P. juliflora is a tree of the Fabaceae family, as is P. laevigata. From a nutritional perspective, mesquite flour contains essential dietary fatty acids (C18:1; C18:2, C18:3) with important health benefits (Matsumoto et al, 2017;Simopoulos, 2002). In addition, the concentration of essential fatty acids is higher than those reported for corn and wheat flour (Muñoz, 2014).…”

Section: Gc-fid Analysismentioning

confidence: 99%

Quantitative analysis of fatty acids in <em>Prosopis laevigata</em> flour

et al. 2019

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Ripe mesquite pods are widely consumed by humans and animals in arid and semi-arid areas for their protein, carbohydrate, crude fiber and fat contents. The goal of this work is to identify and to quantify the fatty acid profile of flour from mesquite pods. Structural assignments were confirmed by the analysis of fragmentation patterns of mass spectra obtained by GC-MS. The results showed that 75% of the fatty acids were unsaturated, of which linoleic acid was predominant, while palmitic and stearic acids, and saturated fatty acids were found in minor proportions.

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“…Meanwhile the medical potentials of unsaturated fatty acids are well documented [23–25]. A cohort study revealed that monounsaturated fatty acids diet could suppress disease activity in RA patients and served as an independent predictor of remission in the RA group [30]. Another important ingredient of SIF, the monounsaturated oleic acid is also proved with substantial anti‐inflammatory effects [31].…”

Section: Discussionmentioning

confidence: 99%

Fatty oil from Securidaca inappendiculata exerted therapeutic effects on adjuvant‐induced arthritis in mice via suppression on fibroblast‐like synoviocyte

Jiang

Yang

et al. 2018

The Kaohsiung J of Med Scie

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Securidaca inappendiculata Hassk. (SI) is a medicinal plant used to treat rheumatoid arthritis (RA) in South China. A substantial amount of fatty oil was isolated from SI (SIF), however little knowledge about its chemical composition and medicinal potentials was obtained. In this study, we analyzed its chemical composition with methyl esterification based GC–MS method, and investigated the therapeutic potentials on adjuvant‐induced arthritis (AA) in mice. MTT and western‐blot methods were employed to investigate its effects on proliferation rate and protein expressions in MH7A cells, respectively. It was revealed SIF was mainly comprised of saturated and monosaturated fatty acids, and the two predominant compounds were palmitic acid (36.89%) and oleic acid (31.12%). Treatment with SIF at 100 mg/kg resulted in significant alleviation of AA severity in mice, together with reduced synovial hyperplasia and inflammatory infiltration in joints, and decreased levels of sialic acid, malondialdehyde and alkaline phosphatase in serum. Results from immunohistochemical assays hinted the protective effects of SIF on joints were associated to the inhibition on production of some pathological factors in synovium, including IL‐1β, TNF‐α and MMP‐9. SIF inhibited the proliferation of MH7A cells in a concentration dependent manner, and abrogated phosphorylation of p65 in vitro. These evidences collectively suggested SIF could suppress the pathological functions of fibroblast‐like synoviocyte, and protect joints from destruction under AA conditions.

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Monounsaturated fatty acids might be key factors in the Mediterranean diet that suppress rheumatoid arthritis disease activity: The TOMORROW study

Cited by 69 publications

References 22 publications

Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis

Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis

Quantitative analysis of fatty acids in <em>Prosopis laevigata</em> flour

Fatty oil from Securidaca inappendiculata exerted therapeutic effects on adjuvant‐induced arthritis in mice via suppression on fibroblast‐like synoviocyte

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