Monotherapy with Tadalafil or Tamsulosin Similarly Improved Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia in an International, Randomised, Parallel, Placebo-Controlled Clinical Trial

Oelke, Matthias; Giuliano, François; Mirone, Vincenzo; Xu, Lei; Cox, David A.; Viktrup, Lars

doi:10.1016/j.eururo.2012.01.013

Cited by 268 publications

(263 citation statements)

References 26 publications

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“…Another randomized parallel placebo controlled clinical trial confirmed that tadalafil or tamsulosin has significant and numerically similar effects on improvement of LUTS when comparing to placebo. Even though, only tadalafil was effective in patients with LUTS and erectile dysfunction (26). There are some previous reports regarding the safety and efficacy of sildenafil (25 or 50mg/day) in decreasing of IPSS as monotherapy or in combination with alpha blocker (7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

Does sildenafil enhance the effect of tamsulosin in relieving acute urinary retention?

et al. 2014

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ARTICLE INFO ______________________________________________________________ ______________________Objective: To compare the safety and efficacy of combined therapy using sildenafil and tamsulosin for management of acute urinary retention (AUR) with tamsulosin alone in patients with benign prostate hyperplasia (BPH). Materials and Methods: 101 patients were enrolled in a randomized placebo-controlled study from June 2009 to April 2012. Patients presenting with an initial episode of spontaneous AUR underwent urethral catheterization and then prospectively randomized to receive tamsulosin 0.4mg plus sildenafil 50mg in group A and tamsulosin 0.4mg plus placebo in group B for three days. Urethral catheter was removed three days after medical treatment and patient's ability to void assessed at the day after catheter removal and seven days later. Patients who voided successfully were followed at least for three months. Results: Mean age of patients was 59.64 ± 3.84 years in group A and 60.56 ± 4.12 years in group B (p value = 0.92). Mean prostate volume and mean residual urine were comparable between both groups (p value = 0.74 and 0.42, respectively). Fifteen patients in group A (success rate: 70%) and nineteen patients in group B (success rate: 62.7%) had failed trial without catheter (TWOC) at 7th day following AUR (p value = 0.3). No significant difference was noted between both groups regarding the rate of repeated AUR at one month and three month follow-up period (p = 0.07 and p = 0.45, respectively). Conclusion: It seems that combination therapy by using 5-phosphodiesterase inhibitor and tamsulosin has no significant advantages to improve urinary retention versus tamsulosin alone.

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Section: Discussionmentioning

confidence: 99%

Does sildenafil enhance the effect of tamsulosin in relieving acute urinary retention?

et al. 2014

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“…Evidence from epidemiological studies suggests that LUTS are closely associated with ED 12, 13, 119. Oelke et al.…”

Section: Discussionmentioning

confidence: 99%

Integrative review on the non‐invasive management of lower urinary tract symptoms in men following treatments for pelvic malignancies

et al. 2015

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SummaryAimTo develop a non‐invasive management strategy for men with lower urinary tract symptoms (LUTS) after treatment for pelvic cancer, that is suitable for use in a primary healthcare context.MethodsPubMed literature searches of LUTS management in this patient group were carried out, together with obtaining a consensus of management strategies from a panel of authors for the management of LUTS from across the UK.ResultsData from 41 articles were investigated and collated. Clinical experience was sought from authors where there was no clinical evidence. The findings discussed in this paper confirm that LUTS after the cancer treatment can significantly impair men's quality of life. While many men recover from LUTS spontaneously over time, a significant proportion require long‐term management. Despite the prevalence of LUTS, there is a lack of consensus on best management. This article offers a comprehensive treatment algorithm to manage patients with LUTS following pelvic cancer treatment.ConclusionBased on published research literature and clinical experience, recommendations are proposed for the standardisation of management strategies employed for men with LUTS after the pelvic cancer treatment. In addition to implementing the algorithm, understanding the rationale for the type and timing of LUTS management strategies is crucial for clinicians and patients.

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“…23 (A) Since iPDE5 is indicated for the treatment of erectile dysfunction, this class of medication may be an option in the treatment of patients presenting both disorders. 22,23,26 (A)…”

Section: Phosphodiesterase-5 Inhibitors (Ipde5s)mentioning

confidence: 99%

“…22,23,26,27 (A) A prospective placebo-controlled study of tadalafil with tamsulosin used as an active comparator showed that tadalafil led to a decrease in tamsulosin-like I-PSS as early as week 1. 23 (A) Since iPDE5 is indicated for the treatment of erectile dysfunction, this class of medication may be an option in the treatment of patients presenting both disorders. 22,23,26 (A)…”

Section: Phosphodiesterase-5 Inhibitors (Ipde5s)mentioning

confidence: 99%

“…[21][22][23][24] (A) The likely mechanisms of action stem from effects on smooth muscle relaxation, endothelial cell proliferation, improved blood flow, and activity on the prostatic efferent nerves. 25 (D) Currently, tadalafil (5 mg once daily) is approved in Brazil for the treatment of urinary symptoms associated with BPH.…”

Section: Phosphodiesterase-5 Inhibitors (Ipde5s)mentioning

confidence: 99%

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Treatment of benign prostatic hyperplasia

Nunes

Manzano

Truzzi

et al. 2017

Rev. Assoc. Med. Bras.

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Monotherapy with Tadalafil or Tamsulosin Similarly Improved Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia in an International, Randomised, Parallel, Placebo-Controlled Clinical Trial

Cited by 268 publications

References 26 publications

Does sildenafil enhance the effect of tamsulosin in relieving acute urinary retention?

Does sildenafil enhance the effect of tamsulosin in relieving acute urinary retention?

Integrative review on the non‐invasive management of lower urinary tract symptoms in men following treatments for pelvic malignancies

Treatment of benign prostatic hyperplasia

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