Monoterpenoids

Connolly, Joseph D.; Hill, Robert A.

doi:10.1007/978-1-4899-4513-6_2

Cited by 4 publications

(4 citation statements)

References 1,423 publications

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“…Plant sterols-stigmasterol and sitosterol were among substances which were being isolated and identified in S. crispus [29]. Besides an important structural component of plant membranes [30,31] several studies have indicated that certain type of phytosterols may possess anticancer activity.…”

Section: Discussionmentioning

confidence: 99%

In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell

Chong

Rahmat

Yeap

et al. 2012

BMC Complement Altern Med

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BackgroundStrobilanthes crispus has been traditionally used as antidiabetic, anticancer, diuretic, antilytic and laxative agent. However, cytotoxicity and antiproliferative effect of S. crispus is still unclear.ResultsStrobilanthes cripus was able to reduce cell viability and proliferation in MTT and BrdU assays. Both cell cycle progression and Tunel assay suggested that IC50 of S. crispus ethanol extract induced sub-G1 cell cycle phase, and DNA fragmentation. On the other hand, translocation of mitochondria cytochrome c release, induction of caspase 3/7 and p53 while suppress XIAP on treated MCF-7 cell were also observed in this study.ConclusionOur findings suggest that S. crispus ethanol extract induced apoptosis and DNA fragmentation on hormone dependent breast cancer cell line MCF-7 via mitochondria dependent p53 apoptosis pathway.

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Section: Discussionmentioning

confidence: 99%

In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell

Chong

Rahmat

Yeap

et al. 2012

BMC Complement Altern Med

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“…1227 The biosynthesis of 5 -cardenolides in Asclepias curassavica has also been studied [1228][1229][1230] and the topic of cardenolide biosynthesis has been reviewed. 1231 Steroidal sapogenins such as diosgenin (106) 1232 and steroidal alkaloids such as solanidine (107), 1233 compounds probably involved in defence against fungal pathogens, are believed to be biosynthesised from cholesterol (Nohara has 672 Natural Product Reports, 1998 isolated a 26-aminocholestanol derivative which may be an intermediate in the formation of the steroidal alkaloids). 1234 Sequential addition of single monosaccharides to the free 3-OH group of these steroid aglycones, resulting in steroidal saponins and steroidal glycoalkaloids respectively, is catalysed by UDP-glucose:sterol --glucosyltransferase (UDPG-SGTase).…”

Section: Biosynthesis Of Plant Steroids and Triterpenes As Secondary ...mentioning

confidence: 99%

The biosynthesis of steroids and triterpenoids

Brown¹

1998

Nat. Prod. Rep.

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“…Of these, cycloartenol, eburicane, and several 3,4- seco -lanostane derivatives have all been identified as active compounds . Other interesting groups of tetracyclic triterpenoids and their degraded derivatives include the cucurbitacins (cucurbitanes), dammaranes, limonoids, and quassinoids. ,− Several lanostane derivatives have been identified as anti-inflammatory, antiviral, or anticancer agents; their effects on cell death, either through necrosis or apoptosis, have been partly implicated in their mechanism of action. ,, …”

Section: Introductionmentioning

confidence: 99%

“…Those derived from tetracyclic skeletons include dammaranes, tirucallanes, euphanes, cucurbitanes, and lanostanes, all of which contain 30 carbons and a gem -dimethyl at C-4. In a series of reviews published starting in 1989, Connolly and Hill have been systematically updating the available information on this group of compounds, including data referring to their cytotoxicity. − …”

Section: Introductionmentioning

confidence: 99%

Lanostanoids from Fungi: A Group of Potential Anticancer Compounds

et al. 2012

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Lanostanes are a group of tetracyclic triterpenoids derived from lanosterol. They have relevant biological and pharmacological properties, such as their cytotoxic effects via induction of apoptosis. This review compiles the most relevant lanostanoids studied from 2000 to 2011, principally those isolated from Ganoderma lucidum and other related fungi, such as Poria cocos, Laetiporus sulphureus, Inonotus obliquus, Antrodia camphorata, Daedalea dickinsii, and Elfvingia applanata, which have great potential as anticancer agents because of their cytotoxic or apoptotic effects. The compounds were selected on the basis of their proapoptotic mechanisms, through their ability to modify transcriptional activities via nuclear factors or genes and the activation or inhibition of pro- or antiapoptotic proteins; studies based only on their cytotoxicity were excluded from this review in the absence of complementary studies on their mechanisms of action. A total of 81 compounds from Ganoderma lucidum and other species from this genus are included, as well as 96 compounds isolated from other fungi, principally Poria cocos. Some of these compounds were found to arrest the cell cycle in the G1 phase, increase levels of p53 and Bax, or inhibit the phosphorylation of Erk1/2 or the activation of NF-κB and AP-1. Other lanostanes have inhibitory effects on the growth of androgen prostate carcinoma through increasing the expression of p21, which activates the tumor suppressor protein p53, while other compounds have been shown to selectively inhibit topo II activity without affecting topo I. General considerations concerning the chemical structure-biological activities of these compounds are also discussed.

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Monoterpenoids

Cited by 4 publications

References 1,423 publications

In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell

In vitro cytotoxicity of Strobilanthes crispus ethanol extract on hormone dependent human breast adenocarcinoma MCF-7 cell

The biosynthesis of steroids and triterpenoids

Lanostanoids from Fungi: A Group of Potential Anticancer Compounds

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