Monoterpenes: Essential Oil Components with Valuable Features

Dehsheikh, Anahita Boveiri; Sourestani, Mohammad Mahmoodi; Dehsheikh, Paria Boveiri; Mottaghipisheh, Javad; Vitalini, Sara

doi:10.2174/1389557520666200122144703

Cited by 47 publications

(29 citation statements)

References 124 publications

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“…EOs are a complex combination of chemical aromatic-smelling low-molecular weight compounds. They are derived from the plants' secondary metabolism [15], leading predominately to monoterpenes [16], sesquiterpenes [17] and their oxygenated derivatives [18]. They are biosynthesized in different plant organs and parts such as flowers, leaves, fruits and roots [15] and are industrially produced mainly by hydro-or steam-distillation [19,20].…”

Section: Essential Oilsmentioning

confidence: 99%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.

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Section: Essential Oilsmentioning

confidence: 99%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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“…The utilization of flavor and fragrance compounds (hereby designated as aroma compounds) is very well established in our current society, as such compounds are extensively used in the food industry (e.g., beverages, processed food, ready-to-eat meals), agrochemicals, household products (e.g., detergents, soaps), cosmetics (e.g., fine fragrances, toiletries and body care commodities) and pharmaceuticals (e.g., dietary supplements and nutraceuticals) [1]. The worldwide market for flavor and fragrance compounds was estimated to reach a value of USD 28.2 billion in 2017 and is forecast to grow at a compound annual growth rate of 5.3% up to 2023, driven by the increased demand for aroma compounds [2].…”

Section: The Importance Of Aroma Compounds In Industrymentioning

confidence: 99%

“…The present review is intended to present an overview of the current advances in the production of monoterpene derivatives as fine chemicals, carried out by bacterial cells and bacterial enzymes. Although this work does not include and extensive description of the biological properties of the monoterpene derivatives generated in the reported bacterial metabolisms (reviewed in [1] and references therein), we highlight the main monoterpene catabolic pathways and bacterial strains currently characterized with molecular approaches as potential source of novel enzymes and novel biomolecules. Major emphasis was placed on the production of monoterpene derivatives with relevant biological activity for application in flavoring and fragrances industries, as well as for the development of agrochemicals and biocontrol agents.…”

Section: Scope Of the Reviewmentioning

confidence: 99%

Current Advances in the Bacterial Toolbox for the Biotechnological Production of Monoterpene-Based Aroma Compounds

2020

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Monoterpenes are plant secondary metabolites, widely used in industrial processes as precursors of important aroma compounds, such as vanillin and (−)-menthol. However, the physicochemical properties of monoterpenes make difficult their conventional conversion into value-added aromas. Biocatalysis, either by using whole cells or enzymes, may overcome such drawbacks in terms of purity of the final product, ecological and economic constraints of the current catalysis processes or extraction from plant material. In particular, the ability of oxidative enzymes (e.g., oxygenases) to modify the monoterpene backbone, with high regio- and stereo-selectivity, is attractive for the production of “natural” aromas for the flavor and fragrances industries. We review the research efforts carried out in the molecular analysis of bacterial monoterpene catabolic pathways and biochemical characterization of the respective key oxidative enzymes, with particular focus on the most relevant precursors, β-pinene, limonene and β-myrcene. The presented overview of the current state of art demonstrates that the specialized enzymatic repertoires of monoterpene-catabolizing bacteria are expanding the toolbox towards the tailored and sustainable biotechnological production of values-added aroma compounds (e.g., isonovalal, α-terpineol, and carvone isomers) whose implementation must be supported by the current advances in systems biology and metabolic engineering approaches.

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“…Bicyclic monoterpenes are very structurally diverse, mainly comprising caranes, thujanes, pinenes, camphanes, and fenchanes. Further variability can be gained by adding double bonds (oxidation) or removing them (reduction), and also by combining with oxygen in the forms of alcohol (-OH), ketone (-CO), aldehyde (-CHO), and ester (-OCO) compounds [18].…”

Section: Monoterpenesmentioning

confidence: 99%

Antimicorbial Potency of Major Functional Foods’ Essential Oils in Liquid and Vapor Phases: A Short Review

et al. 2020

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Due to the increasing risk of chemical contaminations in the application of synthetic fungicides, the use of plant essential oils and extracts has recently been increased. In the present review, the antimicrobial potential of the most active plant-food essential oils in liquid and vapor phases has been reviewed. The volatile isothiocyanates, aldehydes, and phenols, including allyl isothiocyanate, carvacrol, thymol, and eugenol, are considered to be the predominant components of essential oils, possessing significant antimicrobial activities. These components alone or in mixture can be effective. Overall, the antimicrobial activity of aroma compounds depends on the plant species, concentration, and method of application. This review provides useful information about the inhibitory application of the most common plant-foods’ essential oils in liquid and vapor phases against the growth of pathogenic microorganisms. Essential oils (EOs) are promising natural antimicrobial alternatives in food processing facilities. Although the food industry primarily uses spices and herbs to impart flavor, aroma, and pungency to foods, potent EOs represent interesting sources of natural products for food preservation.

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Monoterpenes: Essential Oil Components with Valuable Features

Cited by 47 publications

References 124 publications

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Current Advances in the Bacterial Toolbox for the Biotechnological Production of Monoterpene-Based Aroma Compounds

Antimicorbial Potency of Major Functional Foods’ Essential Oils in Liquid and Vapor Phases: A Short Review

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