Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

Vrabec, Rudolf; Maříková, Jana; Ločárek, Miroslav; Korábečný, Jan; Hulcová, Daniela; Hošťálková, Anna; Kuneš, Jiřı́; Chlebek, Jakub; Kučera, Tomáš; Hrabinová, Martina; Jun, Daniel; Soukup, Ondřej; Andrisano, Vincenza; Jenčo, Jaroslav; Šafratová, Marcela; Nováková, Lucie; Opletal, Lubomı́r; Cahlíková, Lucie

doi:10.1016/j.phytochem.2021.113017

Cited by 9 publications

(2 citation statements)

References 84 publications

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“…Ning et al [235] established a method for the identification of flavonoid chemical constituents of homoisoflavonoids using 1 H-NMR, which can rapidly and accurately identify common flavonoids. For the structural identification of crude extracts, the NMR spectra of the crude extracts were compared with the NMR spectra of compounds already identified in the database to determine the structures of the compounds [236]. For unknown compounds, the structure of natural products can be analyzed by one-and two-dimensional NMR spectroscopy combined with mass spectrometry [237][238][239].…”

Section: Nuclear Magnetic Resonance Spectroscopy (Nmr)mentioning

confidence: 99%

Extraction and Analysis of Chemical Compositions of Natural Products and Plants

Zhang,

Zhao,

Dai

et al. 2023

Separations

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There are many types of natural plants in nature that contain a variety of effective and complex chemical components. These constituents can be categorized as organic acids, volatile oils, coumarins, steroids, glycosides, alkaloids, carbohydrates, phytochromes, etc., all of which play important roles in the fields of pharmaceuticals, food, nutraceuticals, and cosmetics. The study of extraction and chemical composition analysis of natural products is important for the discovery of these active ingredients and their precursors. Therefore, the aim of this article is to review the status of research on the extraction, separation and purification, and structural identification of natural products, to provide a reference for the study of natural products.

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Section: Nuclear Magnetic Resonance Spectroscopy (Nmr)mentioning

confidence: 99%

Extraction and Analysis of Chemical Compositions of Natural Products and Plants

Zhang,

Zhao,

Dai

et al. 2023

Separations

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“…Terpenoid indole alkaloids are a class of PSMs found in various non-model medicinal plants, such as Catharanthus roseus, Rauvolfia serpentina, Ophiorrhiza pumila, and Vinca minor (Luijendijk et al, 1996;Schlager and Drager, 2016;Shi et al, 2020a;Zhan et al, 2020;Yang et al, 2021a;Vrabec et al, 2022). Catharanthus roseus is frequently used as the model plant to reveal a complete TIA biosynthetic pathway (O'Connor and Maresh, 2006).…”

Section: Key Enzymes Involved In the Biosynthesis Of Alkaloidsmentioning

confidence: 99%

Environmental and Genetic Factors Involved in Plant Protection-Associated Secondary Metabolite Biosynthesis Pathways

Zhan

Chen

et al. 2022

Front. Plant Sci.

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Plant specialized metabolites (PSMs) play essential roles in the adaptation to harsh environments and function in plant defense responses. PSMs act as key components of defense-related signaling pathways and trigger the extensive expression of defense-related genes. In addition, PSMs serve as antioxidants, participating in the scavenging of rapidly rising reactive oxygen species, and as chelators, participating in the chelation of toxins under stress conditions. PSMs include nitrogen-containing chemical compounds, terpenoids/isoprenoids, and phenolics. Each category of secondary metabolites has a specific biosynthetic pathway, including precursors, intermediates, and end products. The basic biosynthetic pathways of representative PSMs are summarized, providing potential target enzymes of stress-mediated regulation and responses. Multiple metabolic pathways share the same origin, and the common enzymes are frequently to be the targets of metabolic regulation. Most biosynthetic pathways are controlled by different environmental and genetic factors. Here, we summarized the effects of environmental factors, including abiotic and biotic stresses, on PSM biosynthesis in various plants. We also discuss the positive and negative transcription factors involved in various PSM biosynthetic pathways. The potential target genes of the stress-related transcription factors were also summarized. We further found that the downstream targets of these Transcription factors (TFs) are frequently enriched in the synthesis pathway of precursors, suggesting an effective role of precursors in enhancing of terminal products. The present review provides valuable insights regarding screening targets and regulators involved in PSM-mediated plant protection in non-model plants.

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