Monosodium glutamate intake affect the function of the kidney through NMDA receptor

Mahieu, Stella; Klug, Maximiliano; Millen, Néstor; Fabro, Ana Patricia; Benmelej, Adriana; Contini, María del Carmen

doi:10.1016/j.lfs.2016.02.023

Cited by 32 publications

(8 citation statements)

References 25 publications

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“…Interestingly, monosodium glutamate (MSG) has been regularly used worldwide as a flavor enhancer to stimulate suitable food selection in particular cultures [ 86 ]. Hence, a report of Mahieu et al [ 87 ] revealed that chronic administration of MSG in rats raised both GFR and tubular reabsorption of Na, K and water, which was followed by an upregulation of GluN1 in the kidney. Blockade of NMDAR with MK-801 significantly reversed all the changes induced by monosodium glutamate.…”

Section: Distinctive Physiological and Pathophysiological Roles Ofmentioning

confidence: 99%

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney

et al. 2020

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N-Methyl-d-aspartate receptor (NMDAR) is a glutamate-gated ionotropic receptor that intervenes in most of the excitatory synaptic transmission within the central nervous system (CNS). Aside from being broadly distributed in the CNS and having indispensable functions in the brain, NMDAR has predominant roles in many physiological and pathological processes in a wide range of non-neuronal cells and tissues. The present review outlines current knowledge and understanding of the physiological and pathophysiological functions of NMDAR in the kidney, an essential excretory and endocrine organ responsible for the whole-body homeostasis. The review also explores the recent findings regarding signaling pathways involved in NMDAR-mediated responses in the kidney. As established from diverse lines of research reviewed here, basal levels of receptor activation within the kidney are essential for the maintenance of healthy tubular and glomerular function, while a disproportionate activation can lead to a disruption of NMDAR’s downstream signaling pathways and a myriad of pathophysiological consequences.

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Section: Distinctive Physiological and Pathophysiological Roles Ofmentioning

confidence: 99%

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney

et al. 2020

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“…Besides its important property of behaving as an excitatory neurotransmitter for the central nervous system, its involvement in the formation of the tripeptide glutathione renders this amino acid crucial as a building block of the living cell antioxidant defenses, especially as far as the hydrogen peroxide and lipid hydroperoxide scavenging enzymes of the glutathione peroxidase type are concerned . Moreover, in the form of monosodium glutamate (or sodium hydrogen l ‐glutamate), it has been authorized as a food additive (E‐621) due to its special quality of acting as a flavor enhancer …”

Section: Introductionmentioning

confidence: 99%

Kinetics of the chromium(III)/l‐glutamic acid complexation reaction: Formation, decay, and UV‐vis spectrum of a long‐lived intermediate

Perez‐Benito

Nicolas‐Rivases

2018

Int J of Chemical Kinetics

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The kinetics of the aqueous reaction of Cr(III) with either L-glutamic acid or sodium hydrogen L-glutamate at pH 2.46-5.87 have been followed by means of absorbance readings. The rate of formation of the reaction products showed accelerationdeceleration periods, caused by the accumulation and posterior decay of an intermediate in nonnegligible concentration. A double-exponential integrated rate law allowed obtaining two rate constants for each absorbance-time experimental series, associated with the appearance (k 1 ) and decay (k 2 ) of the long-lived intermediate. An increase of the initial concentrations of either hydrogen L-glutamate (apparent kinetic orders < 1) or hydroxide (kinetic orders = 1) ions resulted in an increase of both k 1 and k 2 , but addition of an inert electrolyte (KNO 3 ) resulted in opposite effects on k 1 (decrease) and k 2 (increase). The experimental activation energies were 83 ± 10 (for k 1 ) and 95 ± 5 (for k 2 ) kJ mol −1 . The electronic spectrum of the low reactivity detected intermediate resembled more closely to that of the blue/green reactant than that of the violet reaction product. The low number of protons set free by the complexating hydrogen L-glutamate ligand seems to suggest that some polymerization of the coordinated amino acid (to form a di-or tripeptide) might take place. The available experimental data indicate that the coordination of the organic ligand must be preceded by the breakdown of a strong Cr(III)-H 2 O chemical bond in the slow steps of the mechanism. K E Y W O R D S chromium(III), complexation reaction, kinetics, L-glutamic acid, long-lived intermediate Int J Chem Kinet. 2018;50:591-603. PEREZ-BENITO AND NICOLAS-RIVASES

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“…Increase in oxidative stress markers is confirmed also by proteomic analysis: also, in this case MSG rats had access only to MSG-poised drinking water, without access to plain water, a condition which hardly can be seen in real life 34 . The effect of either MSG or NaCl added to food and water was also compared: both treatments induced hypertension, while only MSG evoked hyperfiltration followed by sodium, potassium and water reabsorption, with the involvement of NMDA receptors 35 . In this model, no increase in lipid peroxidation was observed, but fibrosis was present 36 .…”

Section: Discussionmentioning

confidence: 99%

Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice

Celestino

Valdez

Brun

et al. 2021

Sci Rep

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Monosodium Glutamate (MSG) is used as flavour enhancer, with potential beneficial effects due to its nutritional value. Given the decline in kidney functions during aging, we investigated the impact of MSG voluntary intake on the kidney of male mice, aged 6 or 18 months. For 2 months, they freely consumed water (control group), sodium chloride (0.3% NaCl) or MSG (1% MSG) in addition to standard diet. Young animals consuming sodium chloride presented signs of proteinuria, hyperfiltration, enhanced expression and excretion of Aquaporin 2 and initial degenerative reactions suggestive of fibrosis, while MSG-consuming mice were similar to controls. In old mice, aging-related effects including proteinuria and increased renal corpuscle volume were observed in all groups. At an advanced age, MSG caused no adverse effects on the kidney compared to controls, despite the presence of a sodium moiety, similar to sodium chloride. These data show that prolonged MSG intake in mice has less impact on kidney compared to sodium chloride, that already in young animals induced some effects on kidney, possibly related to hypertension.

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Monosodium glutamate intake affect the function of the kidney through NMDA receptor

Cited by 32 publications

References 25 publications

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney

Kinetics of the chromium(III)/l‐glutamic acid complexation reaction: Formation, decay, and UV‐vis spectrum of a long‐lived intermediate

Differential effects of sodium chloride and monosodium glutamate on kidney of adult and aging mice

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