Monosodium Glutamate: Feeding of Large Amounts in Man and Gerbils

Bazzano, Gaetano; D’Elia, John A.; Olson, Robert E.

doi:10.1126/science.169.3951.1208

Cited by 45 publications

(22 citation statements)

References 9 publications

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“…We propose that this lowered serum cholesterol in conjunction with the lowered serum LH was responsible for the lowered serum testosterone levels recorded in this study. The significantly lower serum cholesterol recorded for goats given MSG in this present study is in agreement with the reports of Bazzano et al (1970) in humans and gerbils. However, Ahluwalia and Malik (1989) reported no effects on serum cholesterol in mice given MSG for six days.…”

Section: Discussionsupporting

confidence: 93%

“…However, Ahluwalia and Malik (1989) reported no effects on serum cholesterol in mice given MSG for six days. The lowering of serum cholesterol by MSG administration in this study may be attributable to the reported destructive effects of MSG on the arcuate nucleus of the hypothalamus, which is known to partly function in regulation of fat metabolism (Bazzano et al 1970;Ahluwalia and Malik 1989;Dieguez et al 2011).…”

Section: Discussionmentioning

confidence: 74%

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Serum luteinising hormone, testosterone and total cholesterol levels, libido and testicular histomorphology of male West African Dwarf goats orally or subcutaneously treated with monosodium l-glutamate

Ochiogu¹,

Ogwu²,

Uchendu³

et al. 2015

Vet. Med. - Czech

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 74%

Serum luteinising hormone, testosterone and total cholesterol levels, libido and testicular histomorphology of male West African Dwarf goats orally or subcutaneously treated with monosodium l-glutamate

Ochiogu¹,

Ogwu²,

Uchendu³

et al. 2015

Vet. Med. - Czech

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“…The significant lowering of the serum total cholesterol by MSG administration on Day 28 in this present study is corroborated by the reports of Bazzano et al (1970), Ochiogu et al (2015a) and Ochiogu et al (2015b) on studies with gerbils, rats and goats, respectively. However, it is not clear what effect this lowering of serum cholesterol exerted on testosterone concentrations in this study, as it is known that cholesterol is a precursor for testosterone biosynthesis (Hinshelwood 1998).…”

Section: Discussionsupporting

confidence: 80%

The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

Okoye¹,

Ochiogu²,

Onah³

2016

Vet. Med. - Czech

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ABSTRACT:In this study the effects of monosodium l-glutamate (MSG) administration on the reproductive parameters and serum biochemistry of male rabbits were investigated. Sixteen mature male New Zealand mixed-breed of rabbits (Oryctolagus species) weighing 1.1-1.65 kg were used for this study. They were randomised into four groups of four rabbits each. Group A which served as the untreated control, received only distilled water while Groups B, C and D which were the treated groups, received 0.25 g/kg, 0.5 g/kg and 1 g/kg body weight of MSG from a 40% MSG stock solution. The MSG was administered to the rabbits by oral gavage every forty-eight hours for a period of eight weeks. Serum levels of luteinising hormone (LH), testosterone, total cholesterol and total protein, and activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were evaluated on Days 14, 28 and 56 of MSG administration. Results showed that when compared to the untreated group (Group A), on Day 56 of MSG administration the mean serum levels of both LH and testosterone were significantly (P < 0.05) lower in Group D that received 1 g/kg body weight MSG, while the serum cholesterol levels of Group C rabbits that received 0.5 g/kg body weight MSG was significantly (P < 0.05) lower on Day 28 of MSG administration. The mean serum ALT activity of Groups B and C rabbits were significantly (P < 0.05) lower on Day 56 of MSG administration, while the mean serum AST activity of the Group D rabbits was significantly (P < 0.05) higher on Day 14 of MSG administration. There were no significant (P > 0.05) variations in the mean serum total protein between the groups. Testicular histomorphology revealed that MSG administration did not affect the testes of the rabbits as there was no obvious testicular histopathology. It was concluded that administration of MSG to male rabbits significantly lowered serum LH, testosterone and cholesterol levels and serum ALT activity without affecting testicular histomorphology.

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“…This lowered serum cholesterol is believed to be partly responsible for the significantly lower serum testosterone recorded for the MSG-treated rats, as testosterone is one of the steroid hormones synthesised from cholesterol (Stocco, 1998;Hu et al, 2010). The significantly lower serum cholesterol recorded for rats given MSG in this study is in agreement with the report of Bazzano et al (1970) on humans and gerbils, but contrasts with the reports of Ahluwalia and Malik (1989) and Inyang et al (2012).…”

Section: Discussioncontrasting

confidence: 56%

Effects of monosodium-L-glutamate administration on serum levels of reproductive hormones and cholesterol, epididymal sperm reserves and testicular histomorphology of male albino rats

Ochiogu

Ogwu²,

Uchendu

et al. 2015

Acta Veterinaria Hungarica

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This study investigated the effects of administration of monosodium Lglutamate (MSG) on serum gonadotrophin-releasing hormone (GnRH), luteinising hormone (LH), testosterone and total cholesterol (TC), cauda epididymal sperm reserves (CESR) and testicular histomorphology of adult male albino rats. Eighty-four rats, randomly assigned to 7 groups of 12 rats each, were used for the study. Varying low doses (0.25, 0.50 or 1.00 g/kg body weight) of MSG were administered orally or subcutaneously at 48-h intervals for six weeks. Serum GnRH, LH, testosterone and TC, and CESR were evaluated on days 14, 28 and 42 of MSG administration. Testicular histomorphology was evaluated on day 42. The results showed that the mean serum GnRH, LH and testosterone levels, and the CESR of all the treated groups were significantly (P < 0.05) lower than those of the untreated control on days 14, 28 and 42 of MSG administration. The mean serum TC levels of all the treated groups were also significantly (P < 0.05) lower than those of the control group on days 14 and 28. No lesions were observed on sections of the testes. It was concluded that MSG administration for 14, 28 and 42 days led to significantly lower serum levels of GnRH, LH, testosterone and TC, and significantly lower CESR.

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Monosodium Glutamate: Feeding of Large Amounts in Man and Gerbils

Abstract: Oral administration of large amounts of glutamic acid to adult humans and animals in a formula diet appeared to cause no clinical pathological changes. The only biochemically demonstrable effect was a decrease in serum cholesterol and associated beta lipoproteins.

Cited by 45 publications

References 9 publications

Serum luteinising hormone, testosterone and total cholesterol levels, libido and testicular histomorphology of male West African Dwarf goats orally or subcutaneously treated with monosodium l-glutamate

Serum luteinising hormone, testosterone and total cholesterol levels, libido and testicular histomorphology of male West African Dwarf goats orally or subcutaneously treated with monosodium l-glutamate

The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

Effects of monosodium-L-glutamate administration on serum levels of reproductive hormones and cholesterol, epididymal sperm reserves and testicular histomorphology of male albino rats

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