Monosodium glutamate affects cognitive functions in male albino rats

Moneim, Wafaa M. Abdel; Yassa, Heba A.; Makboul, Rania; Mohamed, Nada

doi:10.1186/s41935-018-0038-x

Cited by 20 publications

(16 citation statements)

References 34 publications

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“…Increased IL-6, resistin, and tumor necrosis factors in adipose tissues are the primary effects of MSG on body weight. The elevated serum levels of resistin and insulin can deteriorate the visceral adipose tissue [59]. Additionally, the ingestion of MSG has a local effect.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Graviola (Annona muricata) on Mono Sodium Glutamate-Induced Hepatic Injury in Rats: Antioxidant, Apoptotic, Anti-inflammatory, Lipogenesis Markers, and Histopathological Studies

Shukry

El-Shehawi

El-Kholy

et al. 2020

Animals

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Monosodium glutamate (MSG) is a widely used food additive, and there is a trepidation that MSG plays a critical role in multiple hepatic disorders. This study was planned to investigate Graviola extract (GE) effects on hepatic and cellular alterations induced by MSG. Fifty Wistar rats were randomly allocated into five groups: control (received normal saline), Graviola (received 200 mg/kg body weight), MSG (received 2.4 gm MSG/kg, 15% of Lethal dose (LD50) of MSG), Graviola + monosodium glutamate (MSG + GE; received GE, 200 mg/kg/day and MSG 2.4 gm/kg body weight (BW) for the next four weeks), and monosodium glutamate + Graviola (received MSG only (2.4 gm/kg BW) daily for four weeks, then concomitant with Graviola (200 mg/kg BW) daily for the next four weeks. MSG and GR were administered orally for eight weeks. Our results showed that MSG caused a significant increase in oxidative stress markers malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO), hydrogen peroxide (H2O2), proinflammatory cytokines interleukin 6 (IL-6) level, a tumor protein (P53), hepatic cellular damage, as well as proapoptotic markers caspase-3, and B-cell lymphoma 2 (BCL-2)-like protein 4 (Bax). A significant decrease in superoxide dismutase (SOD), catalase (CAT), glutathione S transferase (GST), reduced glutathione (GSH), and an antiapoptotic agent B-cell lymphoma 2 (BCl-2) was observed. The detected MSG effects were normalized by Graviola administration, either a prophylactic or protecting dose. Besides, Graviola reduced the expression of inducible nitric oxide synthase (iNOS) and hepatic fatty acid synthase (FAS) and led to the upregulation of the silent information regulator protein one gene expression gene (SIRT1).In conclusion, the results suggest that Gaviola’s interrelated antiapoptotic, antioxidant, and anti-inflammatory properties are potential mechanisms to enhance hepatic deficits and protect the liver. Graviola can, therefore, be considered a promising hepatoprotective supplement. Additionally, further human clinical trials are also necessary to validate the present research.

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Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Graviola (Annona muricata) on Mono Sodium Glutamate-Induced Hepatic Injury in Rats: Antioxidant, Apoptotic, Anti-inflammatory, Lipogenesis Markers, and Histopathological Studies

Shukry

El-Shehawi

El-Kholy

et al. 2020

Animals

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“…Wafaa M. et al (2018) demonstrated that giving MSG in low doses caused the male albino rats to gain weight. In addition to changes in brain [28].…”

Section: The Effect Of Msg On Food Intake Obesity and Body Immunitymentioning

confidence: 99%

The Effect of Food Additives (Monosodium Glutamate - MSG) On Human Health - A Critical Review

Al-Agili

2020

JAUC

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According to the famous saying of the medieval physician Paracelsus, "There is no substance without poison. Only the dose determines the extent of the toxic effect." Here, the effect of monosodium glutamate (MSG) on human health and the risks to the health of its frequent use in the short term was addressed and the long term was evaluated according to the studies of several researchers specializing in this regard. Monosodium glutamate (MSG) is known as one of the most popular food additives that classified as a flavor enhancer. Parts of the evidence were reviewed from the literature explaining its effect on immune system cells in addition to metabolic disorders by exposing individuals to obesity and what is known as metabolic syndrome, as well as reviewing a lot of evidence indicating the effect of MSG intake on the health of the kidney, liver and other parts of the body through Practical application to laboratory rats and clinical studies in humans.

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“…High exposure to MSG represents a major health problem in Egypt, as it is found in a large number of food products; especially those directed to kids, within levels exceed the European limit of 10 g/kg (1%) of product. Even if found within the allowable limits in some food products, the over and repeated consumption of these products per day without paying attention to the total amount of MSG ingested exposes the person to critical health challenges in the next years (Abdel Moneim et al, 2018). This study was carried out to investigate the weight control and hepato-renal protective effects of Spirulina in MSG -exposed female rats.…”

Section: Introductionmentioning

confidence: 99%

Spirulina as Anti-Obesity and Hepato-Renal Protective Agent in MSG -Exposed Female Rats

El-Hashash

2021

Alexandria Science Exchange Journal

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High intake of monosodium glutamate (MSG)containing foods was reported as a major health problem in Egypt. Thus, dietary interventions aim to prevent the deleterious effects of this additive were badly needed. This study was carried out to investigate the effect of concurrent consumption of MSG and Spirulina (S. platensis) on body weight as well as hepato-renal functions and histopathology in female rats. Twenty adult female albino rats were divided into four equal groups, including the control group, while groups 2 to 4 were administered 6 mg MSG/kg body weight daily, and kept untreated (group 2), or concurrently fed pelleted balanced diet supplemented with 0.5 and 1 % of Spirulina powder for 6 weeks (groups 3 and 4, respectively). At the end, body weight gain, feed intake and feed efficiency ratio were calculated. Liver and kidney functions were determined in sera, while oxidative stress markers were determined in liver and kidney tissue homogenates. Moreover, specimens from liver and kidney of sacrificed rats were histopathologically examined. On the other hand, phenolic profile of Spirulina powder was identified and quantified by HPLC. Findings indicated that MSG consumption resulted in overweight, liver and kidney dysfunction along with oxidative stress, which was further confirmed by histological staining. Due to the high content of phenolic compounds rather than other antioxidant agents, Spirulina powder exerted anti-obesity properties and alleviated the toxic hepato-renal effects caused by MSG consumption. So, dietary supplementation of MSG -containing food products with Spirulina powder is recommended to prevent its accompanied health abnormalities.

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Monosodium glutamate affects cognitive functions in male albino rats

Abstract: Background: Monosodium Glutamate is a silent toxin in our food, especially our kids' food. Some of the products in the market contain MSG in a level exceed the European limit.

Cited by 20 publications

References 34 publications

Ameliorative Effect of Graviola (Annona muricata) on Mono Sodium Glutamate-Induced Hepatic Injury in Rats: Antioxidant, Apoptotic, Anti-inflammatory, Lipogenesis Markers, and Histopathological Studies

Ameliorative Effect of Graviola (Annona muricata) on Mono Sodium Glutamate-Induced Hepatic Injury in Rats: Antioxidant, Apoptotic, Anti-inflammatory, Lipogenesis Markers, and Histopathological Studies

The Effect of Food Additives (Monosodium Glutamate - MSG) On Human Health - A Critical Review

Spirulina as Anti-Obesity and Hepato-Renal Protective Agent in MSG -Exposed Female Rats

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