Monopolar spindle 1 contributes to tamoxifen resistance in breast cancer through phosphorylation of estrogen receptor α

Zhang, Xuemiao; Huang, Linfei; Sun, Jing; Liu, Jialong; Zong, Yulong; Wan, Luming; Yang, Xiaopan; Yan, Xue; Zhang, Yanhong; Zhao, Ruzhou; Liu, Jing; Zhong, Hui; Wei, Congwen; Yang, Xiaoli; Tai, Yanhong; Han, Yue; Wang, Yanhai

doi:10.1007/s10549-023-07098-5

Cited by 1 publication

(2 citation statements)

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“…Corroborating our findings, in recent work by Zhang's group it was discovered that threonine tyrosine kinase (TTK) overexpression can make breast cancer cells (MCF-7 and T47-D) resistant to tamoxifen (Zhang et al, 2023). Mechanistically, co-immunoprecipitation and proximity ligation assays revealed that threonine tyrosine kinase (TTK) can interact with ERα, stimulating its transactivation activity in a kinase activitydependent manner (Zhang et al, 2023). Therefore, it is suggested that threonine tyrosine kinase (TTK) may contribute to resistance to hormone therapy and as a potential therapeutic target in hormone-dependent breast cancer.…”

Section: Discussionsupporting

confidence: 84%

“…Our results demonstrated that high threonine tyrosine kinase (TTK) expression was significantly correlated with resistance to endocrine therapy in patients subtyped as Luminal. Corroborating our findings, in recent work by Zhang's group it was discovered that threonine tyrosine kinase (TTK) overexpression can make breast cancer cells (MCF-7 and T47-D) resistant to tamoxifen (Zhang et al, 2023). Mechanistically, co-immunoprecipitation and proximity ligation assays revealed that threonine tyrosine kinase (TTK) can interact with ERα, stimulating its transactivation activity in a kinase activitydependent manner (Zhang et al, 2023).…”

Section: Discussionsupporting

confidence: 75%

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Altered threonine tyrosine kinase (TTK) expression is associated with adverse clinical outcomes in breast tumors: An in silico approach

Silva,

Cruz,

Vieira

et al. 2023

RSD

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The most common and lethal malignancy in women on a global scale remains breast cancer. Threonine tyrosine kinase (TTK) has been shown to be a critical mitotic spindle assembly checkpoint (SAC) molecule, resulting in correct chromosome segregation and maintenance of genomic stability. Therefore, the present study was carried out to evaluate the expression pattern of threonine tyrosine kinase (TTK) in breast cancer and its potential prognostic and predictive value for therapeutic response using bioinformatics tools. Web platforms containing clinical information and cDNA microarray data were selected to perform in silico analyzes of the potential threonine tyrosine kinase (TTK) marker. The threonine tyrosine kinase (TTK) gene was found to be differentially expressed in tumor samples when compared to healthy breast tissue samples (p<0.0001) and the TNBC subtype exhibited the highest expression of threonine tyrosine kinase (TTK) relative to the other subtypes (p<0.0001). Furthermore, Kaplan-Meier curves revealed that high threonine tyrosine kinase (TTK) levels corresponded to an unfavorable outcome for overall survival (p<0.0001), as well as for recurrence-free survival (p<0.0001) and distant metastasis-free survival (p<0.0001). Finally, differential expression of threonine tyrosine kinase (TTK) was related to the response of breast cancer patients to different therapies. Our cumulative results demonstrate that threonine tyrosine kinase (TTK) may be a promising biomarker for predicting prognosis and therapeutic response in breast cancer patients.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 75%