Monophosphoryl Lipid A-Rhamnose Conjugates as a New Class of Vaccine Adjuvants
Rajendra Rohokale,
Jiatong Guo,
Zhongwu Guo
Abstract:Adjuvant is an integral part of all vaccine formulations but only a few adjuvants with limited efficacies or application scopes are available. Thus, developing more robust and diverse adjuvants is necessary. To this end, a new class of adjuvants having αand β-rhamnose (Rha) attached to the 1-and 6′-positions of monophosphoryl lipid A (MPLA) was designed, synthesized, and immunologically evaluated in mice. The results indicated a synergistic effect of MPLA and Rha, two immunostimulators that function via intera… Show more
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