Monophasic versus biphasic hyaluronic acid filler for correcting nasolabial folds: a systematic review and meta‐analysis

Ghaddaf, Abdullah A.; Aljefri, Yara E; Alharbi, Fahad; Sharif, Rahaf K; Alnahdi, Wejdan; Baaqeel, Rasha

doi:10.1111/jocd.14632

Cited by 4 publications

(5 citation statements)

References 41 publications

(150 reference statements)

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“…However, existing research has not found significant differences in the safety of HA with different cross-linking degrees. 39 Unfortunately, data on the cross-linking degree of HA have rarely been reported in the cases included, so this study could not compare the safety of injection under different cross-linking degrees.…”

Section: Discussionmentioning

confidence: 98%

Clinical Manifestations and Prognosis of Embolism Caused by Filler Injection in Different Facial Regions

Zhuang,

Zheng,

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: Embolism is a serious complication after facial filling, with a usually poor prognosis of the symptoms after embolism. The authors systematically reviewed reported cases of facial vascular embolism, explored the relationship between the location and material used for facial filling and occurrence of vascular embolism, and assessed the prognosis of complications after vascular embolism. Methods: This study provides a systematic review of published cases of vascular embolism after facial filling. A summary of the filling materials and filling sites for each case, the adverse reactions and embolized blood vessels, a recording of the time when each patient experienced adverse reactions and started treatment, and a presentation of their prognosis are provided. Results: The frontal, eyebrow, and nose are common filling sites causing facial embolism. The main clinical manifestations after embolism were visual impairment, skin necrosis, and ptosis. The prognosis of visual impairment after embolization was poor, whereas skin necrosis and ptosis generally improved after treatment. Conclusions: This article aimed to review the clinical manifestations, therapies, and prognosis of embolism after facial filling. A better understanding of these complications can help clinicians to detect the occurrence of complications as early as possible and give patients timely treatment.

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Section: Discussionmentioning

confidence: 98%

Clinical Manifestations and Prognosis of Embolism Caused by Filler Injection in Different Facial Regions

Zhuang,

Zheng,

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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“…Their analysis revealed that the most frequent AEs were injection-related, such as tenderness, swelling, bruising, mass, and pain. Another meta-analysis evaluated the difference between monophasic vs. biphasic hyaluronic acid fillers for correcting nasolabial folds [ 23 ]. The study found injection site pain to be the main complaint after receiving dermal fillers.…”

Section: Reviewmentioning

confidence: 99%

“…Various systematic reviews and meta-analyses have been conducted to investigate the effectiveness, safety, and adverse events of dermal fillers injected into the nasolabial folds [20][21][22][23]. However, each meta-analysis is distinct in that it each evaluates certain dermal fillers.…”

Section: Previous Studies On Adverse Events Of Dermal Fillersmentioning

confidence: 99%

“…Although there was no significant difference in the effectiveness of the HA dermal filler with and without lidocaine, the main adverse events that were reported for both groups consisted of swelling, erythema, bruising, itching, and induration. Two additional meta-analyses have been conducted evaluating the effectiveness and safety of monophasic and biphasic HA fillers for the treatment of nasolabial folds [ 22 - 23 ]. Both studies reported that the monophasic HA filler was more effective in the treatment of nasolabial folds.…”

Section: Introductionmentioning

confidence: 99%

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Adverse Events Reported From Hyaluronic Acid Dermal Filler Injections to the Facial Region: A Systematic Review and Meta-Analysis

Colon¹,

Mirkin²,

Hardigan³

et al. 2023

Cureus

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Dermal filler injections are one of the most popular cosmetic procedures in the United States. Of the many options available, hyaluronic acid (HA) dermal fillers like Juvederm or Restylane are often used. Despite their use and popularity, adverse events are known to occur from these procedures. Although most outcomes may be mild and resolve over time, rare instances of severe complications cannot be ignored, as these effects may be irreversible. Healthcare practitioners and patients must be aware of these risks, as these cosmetic procedures can affect the patient’s quality of life. The aim of this study was to evaluate the incidence of adverse events (AEs) reported from the use of hyaluronic acid dermal fillers in the facial region. A systemized search of randomized controlled trials was conducted using Cochrane Central, Embase, Medical Literature Analysis and Retrieval System Online (MEDLINE), and the Web of Science databases. After screening for eligibility and conducting a critical appraisal of the articles, 19 studies were retained for the final review. The meta-analysis results included different side effects by facial location, i.e., nasolabial fold (NLF) vs. other (midface, perioral line, and lip region). The midface includes the anteromedial cheek region, the zygomaticomalar region, and the submalar region. The adverse events were swelling, pain, erythema, bruising, lumps and bumps, firmness, tenderness, itching, and skin discoloration. A significant difference was found in individuals experiencing swelling, lumps or bumps, and firmness at the midface, perioral line, and lip region versus the nasolabial fold site. There was no significant difference in the proportion of individuals experiencing pain, erythema, bruising, tenderness, itching, or skin discoloration at the nasolabial fold site versus the other sites. The study highlights the prevalence of common AEs that can result from HA dermal fillers like Juvederm or Restylane, thus emphasizing the importance of healthcare professionals explaining the risk and benefits to patients.

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“…In the past decades, sodium hyaluronate-based fillers have been widely promoted because of their good biocompatibility and reversibility and are increasingly accepted by patients owing to the minimally invasive procedure and rapid recovery [1,2]. However, the maintenance and effectiveness of filling effects remain a concern, and the filling effect may gradually weaken over time [3].…”

Section: Introductionmentioning

confidence: 99%

Objective Noninvasive Measurement of the Volumizing Effect of a Dermal Filler: An In Vivo Study

Liu,

Niu,

Shi

et al. 2024

Aesth Plast Surg

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Background Information about the volumizing effects of dermal fillers is critical for physicians’ understanding of product features and prudent decision-making in clinical practice. It is important for material engineers to develop and optimize new dermal fillers, especially when comparing the physiochemical properties of a new product with those of existing fillers that are used worldwide. Objective This study aimed to establish a reliable, noninvasive method for in vivo quantitative evaluation of the filling effect in order to predict possible effectiveness after filler injection and to evaluate the degradation trend over time. Methods A rabbit model of ear injection with dermal fillers was established. Hyaluronic acid (HA) filler was injected into the subcutaneous layer of rabbit ears, resulting in a stable skin bulge. Ultrasonography was used to noninvasively measure the skin bulge for volume calculation; the volume change was analyzed periodically until 38 weeks. Pathological examination, the gold standard, was performed to confirm degradation. Results The immediate volumizing effect of HA filler injection was macroscopically observed as a local skin bulge. Ultrasound was able to precisely detect the shape of the filler and calculate the length, width, and height of the skin bulge at each time point. The degree of uplift and amount of residual samples in the pathological evaluation were consistent with the results of morphological observation using ultrasound. Conclusion Evaluation of the volume impact of dermal filler through the rabbit ear injection model evaluation enables material science evaluation in the early stage of material development, and has certain clinical reference value. Level of Evidence I This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Monophasic versus biphasic hyaluronic acid filler for correcting nasolabial folds: a systematic review and meta‐analysis

Cited by 4 publications

References 41 publications

Clinical Manifestations and Prognosis of Embolism Caused by Filler Injection in Different Facial Regions

Clinical Manifestations and Prognosis of Embolism Caused by Filler Injection in Different Facial Regions

Adverse Events Reported From Hyaluronic Acid Dermal Filler Injections to the Facial Region: A Systematic Review and Meta-Analysis

Objective Noninvasive Measurement of the Volumizing Effect of a Dermal Filler: An In Vivo Study

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