Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones

Турсунова, Н. В.; Сыров, В. Н.; Khushbaktova, Z A; Tornuev, Yu. V.; Клинникова, М. Г.

doi:10.1007/s10517-021-05349-3

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…A. Alahmari reported that furano-sesquiterpenes have a broad range of cytoprotective effects against various chemical or physical stimuli that induce cellular injury, where sesquiterpenes act as electron donors to break off the radical system via reaction with reactive oxygen species and then transform them into the most stable product (Tursunova et al, 2021;Yousefi-Manesh et al, 2021). Interestingly, this property contributed to the ability of AME to stimulate the biosynthesis of metabolites with thiol groups, which are known to protect cells from oxidative stress (Bone, 2003).…”

Section: O N L I N E F I R S T a R T I C L Ementioning

confidence: 99%

Sublethal Doses of Clove Oil Deplete the Energy Reserves and Downregulate the Carbohydrate Metabolizing Enzymes in the 4th Instar Larvae of Trogoderma granarium

Ilyas,

Riaz,

Rasheed

et al. 2024

PJZ

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The kidney is one of the target organs whose structure and functions are significantly influenced by toxins. Because the protective impact of myrrh resin on renal damage induced by alcohol intake has not been previously evaluated, this study was designed to investigate the in vivo antioxidant activity of aqueous myrrh extract (AME) on oxidative stress-dependent nephrotoxicity caused by ethanol in rats. Male Sprague-Dawley rats orally received 40% ethanol (3 g kg -1 ) and were then orally treated with (500 mg kg -1 ) AME daily for 30 days. Kidney function, oxidant and antioxidant status, and histopathology alterations in renal tissue were measured. Animals that received ethanol displayed nephrotoxicity, as confirmed by markedly increased serum creatinine, urea, and uric acid levels along with histological changes, including shrunken glomeruli, necrosis, inflammatory cell infiltration, congestion, and edema. They also exhibited significantly elevated lipid peroxidation and oxidant radicals with decreased antioxidant parameters in renal tissue. In contrast, AME alone did not cause renal injury, and it was able to notably improve the toxic impacts of ethanol in the kidney when administered together. In conclusion, AME provided preservation against ethanol toxicity by scavenging reactive oxygen species (ROS) and relieving oxidative stress as a result of its rich chemical content of furano-sesquiterpenes, which possess powerful antioxidant activities.

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Section: O N L I N E F I R S T a R T I C L Ementioning

confidence: 99%

Sublethal Doses of Clove Oil Deplete the Energy Reserves and Downregulate the Carbohydrate Metabolizing Enzymes in the 4th Instar Larvae of Trogoderma granarium

Ilyas,

Riaz,

Rasheed

et al. 2024

PJZ

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“…The Curcumol SQ from Curcuma kwangsiensis (Zingibetaceae) inhibited the VEGF/AKT/eNOS signaling pathway, and reduced expression of NO, inhibiting liver angiogenesis and mediating anti-fibrotic effects in liver [66]. SQ lactones from Artemisia leucodes (Asteraceae) showed hepato-protective properties, stimulating changes in NO metabolism in the monooxygenase and NOergic systems in hepatocytes in animals with acute toxic hepatitis [115]. In addition, alantolactone, a SQ lactone from Inula helenium (Asteraceae), decreased the expression of COX-2, iNOS, MMPs, and a disintegrin and metalloproteinase with thrombospondin motif 5 induced by IL-1β in mouse chondrocytes in an osteoarthritis model [116].…”

Section: Production Of No In Inflammation Inflammatory Markers and It...mentioning

confidence: 99%

The Complexity of Sesquiterpene Chemistry Dictates Its Pleiotropic Biologic Effects on Inflammation

et al. 2022

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Sesquiterpenes (SQs) are volatile compounds made by plants, insects, and marine organisms. SQ have a large range of biological properties and are potent inhibitors and modulators of inflammation, targeting specific components of the nuclear factor-kappaB (NF-κB) signaling pathway and nitric oxide (NO) generation. Because SQs can be isolated from over 1600 genera and 2500 species grown worldwide, they are an attractive source of phytochemical therapeutics. The chemical structure and biosynthesis of SQs is complex, and the SQ scaffold represents extraordinary structural variety consisting of both acyclic and cyclic (mono, bi, tri, and tetracyclic) compounds. These structures can be decorated with a diverse range of functional groups and substituents, generating many stereospecific configurations. In this review, the effect of SQs on inflammation will be discussed in the context of their complex chemistry. Because inflammation is a multifactorial process, we focus on specific aspects of inflammation: the inhibition of NF-kB signaling, disruption of NO production and modulation of dendritic cells, mast cells, and monocytes. Although the molecular targets of SQs are varied, we discuss how these pathways may mediate the effects of SQs on inflammation.

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Dracotangusions A and B, two new sesquiterpenes from Dracocephalum tanguticum Maxim. with anti-inflammatory activity

Wang,

Li,

Wei

et al. 2024

Natural Product Research

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Two new guaiane sesquiterpenoids were isolated from the dried aerial parts of Dracocephalum tanguticum Maxim., named as dracotangusions A (1) and B (2), together with four known sesquiterpenoids, which was identified as Curcumenone (3), (4Z,7Z,9Z)-11-Hydroxy-4,7,9-germacratriene-1,6-dione (4), Kobusone (5), and (1S,10S), (4S, 5S) -(+)-germacrone-1(10)-4-diepoxide (6). The structures of isolates were determined by UV, IR, HR-ESI-MS and NMR analysis. What is noteworthy is that four known sesquiterpenoids were isolated for the first time from the genus of Dracocephalum L.. All compounds inhibited the extremely significant difference (p<0.01) in anti-inflammatory activity, suggesting that these compounds may be promising candidates as an anti-inflammatory agent.

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Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones

Cited by 4 publications

References 9 publications

Sublethal Doses of Clove Oil Deplete the Energy Reserves and Downregulate the Carbohydrate Metabolizing Enzymes in the 4th Instar Larvae of Trogoderma granarium

Sublethal Doses of Clove Oil Deplete the Energy Reserves and Downregulate the Carbohydrate Metabolizing Enzymes in the 4th Instar Larvae of Trogoderma granarium

The Complexity of Sesquiterpene Chemistry Dictates Its Pleiotropic Biologic Effects on Inflammation

Dracotangusions A and B, two new sesquiterpenes from Dracocephalum tanguticum Maxim. with anti-inflammatory activity

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