Mononuclear Cu^II−Phenolate Bioinspired Complex is Catalytically Promiscuous: Phosphodiester and Peptide Amide Bond Cleavage

Abstract

In this work, the cleavage activity of the metal complex [Cu(C(21)H(21)N(3)O(2))(OH(2))(2)](2+) is demonstrated to occur toward double-stranded DNA, in addition to its previously described amide bond cleavage activity, thus suggesting catalytic promiscuity for this complex.

Synthesis, structure, magnetism, and hydrolase and catecholase activity of a new trinuclear copper(II) complex

“…While several enzymes displaying catalytic promiscuity have been the subject of recently reported investigations [6], there are few examples of synthetic analogues which exhibit such multifunctional activities [7][8][9][10][11].…”

An unusual partial occupancy of labile chloride and aqua ligands in cocrystallized isomers of a nickel(II) complex bearing a tripodal N 4-donor ligand

“…In the last two decades, our group and others have exploited mononuclear first-row transition-metal complexes containing two labile cis ligands as biomimetic or bio-inspired homogeneous catalysts for a great variety of reactions, such as the oxidation of catechol and cyclohexane (Ferre et al, 2017), the hydrolysis of proteins (Oliveira et al, 2009), phosphodiesters (Scarpellini et al, 2003;Kettenmann et al, 2018) and polysaccharides (Concia et al, 2017), and, more recently, water splitting (Luo et al, 2016). They have also been studied as prodrugs and carrier prototypes for the selective delivery of bioactive substances (Pires et al, 2016;de Souza et al, 2016).…”

Synthesis, structure, protein binding of Cu(II) complexes with a tridentate NNO Schiff-base ligand

“…Current interest in copper(II) complexes is stemming from their potential use as antimicrobial, antiviral, anti-inflammatory, antipyretic, enzyme inhibitors, or chemical nucleases [6][7][8][9][10][11]. For example, Ma et al have synthesized Cu(II) complexes which could inhibit different enzymatic activities and induce cell apoptosis [12].…”