Mononeuropathy Multiplex in Sickle Cell Disease: A Complication in Need of Recognition

Ischemic Monomeric Neuropathy in a Woman with Sickle Cell Anaemia

“…Size and number of nutrient vessels that supply the different peripheral nerves are different among individuals and among nerves in the same individual. These variations make certain individuals and certain nerve regions even in the same individual more susceptible when exposed to ischemia [14]. Animal studies have found the proximal tibial and peroneal nerves, distal sciatic nerve, and distal foot nerves to be most vulnerable to ischemia [14].…”

“…These variations make certain individuals and certain nerve regions even in the same individual more susceptible when exposed to ischemia [14]. Animal studies have found the proximal tibial and peroneal nerves, distal sciatic nerve, and distal foot nerves to be most vulnerable to ischemia [14]. In humans, the peroneal, sural, tibial, ulnar, median, and radial nerves are most frequently affected by ischemia [11–13].…”

“…In humans, the peroneal, sural, tibial, ulnar, median, and radial nerves are most frequently affected by ischemia [11–13]. The extensive peripheral nerve vascular supply and the widespread network of large capillaries of the peripheral nerves could possibly explain the reason why ischemic neuropathy is rare in SCD [14]. …”

Neurologic complications of sickle cell disease

“…Mononeuropathy resulting from peripheral nerve infarction, as a complication of sickle vaso-occlusive crisis, is uncommon. Reports of patients with SCD who developed acute mononeuropathy multiplex in the setting of sickle cell pain crisis suggests a multifocal nerve disorder resulting from an ischemic process caused by a sickle cell vaso-occlusive crisis (Roohi et al, 2001).…”

Upper limb peripheral neuropathy in sickle cell anemia: MR neurography appearances

“…[456] Other reported involvements include the mandibular nerve,[7] trigeminal nerve,[8] optic nerve,[910] median nerve,[11] and lower extremity (sural, tibial, and peroneal) nerves. [1213] The diagnosis in these case reports was mainly established on clinical basis supplemented by electrophysiological studies.…”