Mononeuropathy associated with hyperthyroidism.

Ijichi, Shinji; Niina, Katsuhiko; Tara, M; Nakamura, Fumiaki; Ijichi, Nobuhiro; Izumo, S; Osame, Mitsuhiro

doi:10.1136/jnnp.53.12.1109

Cited by 14 publications

(5 citation statements)

References 3 publications

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“…Electrophysiological evidence of peripheral neuropathy was confirmed in 24% of the patients. Other patients have been described with carpal tunnel syndrome or a mononeuropthy 18–20 . In most cases the neuropathy has been deemed due to thyrotoxicosis, largely because of the apparent simultaneous presence of the two conditions and resolution of the neuropathy after correction of the thyrotoxicosis.…”

Section: Neurological Disordersmentioning

confidence: 99%

Neuromuscular complications of thyrotoxicosis

Kung

2007

Clinical Endocrinology

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Thyroid hormones exert multiple effects on the neuromuscular system and the brain, with the most important being their role in stimulating the development and differentiation of the neuromuscular system and brain in foetal and neonatal life. In the presence of hyperthyroidism, muscular and neurological symptoms may be the presenting clinical features of the disease. The frequency and severity of neuromuscular complications vary considerably and are probably related to the degree of hyperthyroidism, although in some patients the neuromuscular dysfunction is caused by associated disorders rather than by hyperthyroidism per se. This update focuses on the most common neurological and muscular disorders that occur in patients with thyrotoxicosis. It is beyond the scope of this paper to discuss thyroid eye disease and cardiac complications, in themselves separate complications of specific myocytes.

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Section: Neurological Disordersmentioning

confidence: 99%

Neuromuscular complications of thyrotoxicosis

Kung

2007

Clinical Endocrinology

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“…There is no known association between subclinical hyperthyroidism and a mononeuropathy like Bell's palsy. However, several case reports linked hyperthyroidism with mononeuropathies, such as peroneal palsy, meralgia paraesthetica (36), and facial palsy (37).…”

Section: Discussionmentioning

confidence: 99%

Association Between Thyroid-Stimulating Hormone Level and Bell's Palsy

et al. 2023

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Objective To investigate whether dysregulated thyroid hormone function is associated with Bell's palsy. Study Design Cross-sectional. Setting Electronic medical record database of Clalit Health Services (CHS). CHS is an Israeli payer-provider, integrated health care system, serving >4.5 million members (54% of the Israeli population). Patients Older than 18 years with Bell's palsy, during 2002 to 2019. Interventions None. Methods A total of 1,374 patients with Bell's palsy who had thyroid-stimulating hormone (TSH) blood levels measured up to 60 days before the palsy were matched (1:2) for age and sex with 2,748 controls who had TSH blood levels and no history of Bell's palsy. Results Retrospective review of the CHS database, from 2002 to 2019 yielded 11,268 patients with Bell's palsy, of which, 1,374 met the inclusion criteria. Mean age was 57.9 years, and 61.4% were female. A higher percentage of patients in the Bell's palsy group had low TSH (≤0.55 mIU/L) compared with controls (5.7% vs. 3.6%, p < 0.001). Low TSH compared with TSH > 0.55 mIU/L, was independently associated with 1.45-fold increased odds for having Bell's palsy (95% CI 1.11–2.02, p < 0.001), when controlled for age, sex, body mass index, diabetes, hypertension, prior cerebrovascular accident, hemoglobin level, and purchasing thyroid hormone drugs. Among the patients with TSH ≤ 0.55 mIU/L, 95.5% had normal free thyroxin and 97.7% had normal free triiodothyronine levels (subclinical hyperthyroidism). For 47.1% of patients, TSH remained ≤0.55 mIU/L, 3 to 12 months after the Bell's palsy occurred and most patients had normal free thyroxin (95.4%) and normal free triiodothyronine (91.8%). Conclusions Subclinical hyperthyroidism is independently associated with Bell's palsy after controlling for multiple confounding factors.

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“…Głównym objawem miastenii jest męczliwość mięśni [17][18][19][20][21]. Równocześnie obserwacje kliniczne zwracają uwagę na liczne objawy tyreotoksykozy związane z układem nerwowym i mięśniowym, takie jak osłabienie siły i zaniki mięśni szkieletowych, porażenia nerwów, dysfonię [22][23][24][25][26][27][28][29]. Feibel i inni autorzy opisują neuropatię w przebiegu tyreotoksykozy jako paraplegię Basedowa [30,31].…”

Section: Dyskusjaunclassified

Graves` disease and myasthenia gravis in a teenager – diagnostic problems

Bury¹,

Klatka²

2015

Pediatr. Endocrinol.

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Przyjmuje się, że u podłoża autoimmunologicznych zespołów niewydolności wielogruczołowej leży defekt genetyczny dziedziczony bądź będący wynikiem świeżej mutacji, a także polimorfizm dotyczący układu antygenów zgodności tkankowej HLA. Za allele predysponujące do wystąpienia chorób autoimmunologicznych uważa się: DRB1*03 i/lub 04, DQA1*0301 i/lub *0501 oraz DQB1*0302 i/lub 0201, natomiast allele protekcyjne to: DRB1*1501 i/lub *07 i /lub *11, DQA1*0102 i/lub 0201 oraz DQB1*0602 i/lub 0301 [1]. Do rozwoju chorób autoimmunologicznych u osób predysponowanych genetycznie przyczynia się współwystępowanie różnych czynników środowiskowych, do których zalicza się między innymi: infekcje bakteryjne i wirusowe, urazy, leki, promieniowanie ultrafioletowe, stres, dietę [2,3]. Fakt, że chorują częściej kobiety w okresie prokreacyjnym, zwraca uwagę na potencjalną rolę estrogenów, progesteronu czy prolaktyny w rozwoju powyższych jednostek chorobowych [4,5]. Chociaż prawie każdy organ może być celem ataku autoimmunologicznego, liczne badania podkreślają, że układ endokrynny jest szczególnie podatny (wrażliwy, nieodporny) na tego typu oddziaływania. Choroby autoimmunologiczne tarczycy, wysptrzustki i kory nadnerczy stanowią ponad 50% wszystkich chorób autoimmunologicznych narządowospecyficznych [6]. Coraz więcej jest również dowodów na interakcje pomiędzy układem immu

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Mononeuropathy associated with hyperthyroidism.

Abstract: Figure CTscan We are grateful to Ms Laura Cataldo and Ms Renata Defrancesco for their help in preparing this manuscript.

Cited by 14 publications

References 3 publications

Neuromuscular complications of thyrotoxicosis

Neuromuscular complications of thyrotoxicosis

Association Between Thyroid-Stimulating Hormone Level and Bell's Palsy

Graves` disease and myasthenia gravis in a teenager – diagnostic problems

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