Mononeuritis multiplex in acquired amegakaryocytic thrombocytopenia

Abstract

Mononeuritis multiplex involves inflammation of two or more nerves, typically in unrelated parts of the body. It has been well described in bleeding disorders like idiopathic thrombocytopenic purpura (ITP) and Hemophilia. Acquired amegakaryocytic thrombocytopenia (AAT) is a bleeding diathesis characterized by thrombocytopenia but with reduced number of megakaryocytes in the bone marrow, as against ITP. Though AAT is a well described entity, peripheral nervous system manifestations have not been described so far. We report a young man who has presented with bleeding diathesis and mononeuritis multiplex due to AAT. The mechanism of development of mononeuritis multiplex and treatment options are discussed.

Clinical and Neurophysiological Evidence of Mononeuritis Multiplex During the COVID-19 Era

“…In idiopathic thrombocytopenia purpura, an intraneural hematoma under the epineurium and between the fascicles was shown to be the source of a similar neuropathy. However, there is a paucity of reports that discuss the association between acquired amegakaryocytic thrombocytopenia and mononeuritis multiplex [19].…”