Monomer-Coated Very Small Superparamagnetic Iron Oxide Particles as Contrast Medium for Magnetic Resonance Imaging

Wagner, Susanne; Schnorr, Jörg; Pilgrimm, Herbert; Hamm, Bernd; Taupitz, Matthias

doi:10.1097/00004424-200204000-00002

Cited by 140 publications

(100 citation statements)

References 39 publications

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“…Hohenberg (HPI Hamburg)), e, f commercially available monodisperse polymers SPIO from Ocean NanoTech (www.oceannanotech.com), e SHP-15 (15 ± 1.5 nm, scale 50 nm) and f SHP-40 (40 ± 4 nm). Table 1 Superparamagnetic iron oxide particles in clinical application and clinical and preclinical evaluation (modified according to [43] and [28] form for simultaneous imaging and treatment (theranostics) is proposed [46]. An overview of the SPIO currently used in clinical application and testing is provided in • " Table 1.…”

Section: Particle Size and Coatingsmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

124

101

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Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based ?NMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy. Key Points: Citation Format:

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Section: Particle Size and Coatingsmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

124

101

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“…Preclinical and clinical data on these substances show that blood clearance of VSOP is faster compared to sterically stabilized USPIO. 5,20,22,28 Our findings suggest that microvesicles might be a suitable imaging target for VSOP administered as a contrast medium for the detection and characterization of atherosclerotic plaques by MRI. Microvesicles have recently been proposed to be an important surrogate marker for plaque instability.…”

Section: Discussionmentioning

confidence: 72%

“…20,21 VSOP have been described in detail elsewhere. 20,22 Briefly, their basic properties are: a core diameter of 4 nm; hydrodynamic diameter of 7 nm; T1-relaxivity of 18.7; and T2-relaxivity of 30 L/(mmol × seconds) at 0.47 T. VSOP are stabilized with citrate, an anionic monomeric coating. The concentration of the active substance is 27.9 g Fe/L, which corresponds to 0.5 mol Fe/L.…”

Section: Contrast Mediummentioning

confidence: 99%

Contrast-enhanced MR imaging of atherosclerosis using citrate-coated superparamagnetic iron oxide nanoparticles: calcifying microvesicles as imaging target for plaque characterization

Wagner¹,

Schnorr²,

Ludwig³

et al. 2013

IJN

Self Cite

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Objective:To evaluate the suitability of citrate-coated very small superparamagnetic iron oxide particles (VSOP) as a contrast agent for identifying inflammation in atherosclerotic lesions using magnetic resonance imaging (MRI). Methods and results: VSOP, which have already been evaluated as a blood pool contrast agent for MR angiography in human clinical trials, were investigated in Watanabe heritable hyperlipidemic rabbits to determine to what extent their accumulation in atherosclerotic lesions is a function of macrophage density and other characteristics of progressive atherosclerotic plaques. In advanced atherosclerotic lesions, a significant MRI signal loss was found within 1 hour after intravenous administration of VSOP at the intended clinical dose of 0.05 mmol Fe/kg. Histological examinations confirmed correlations between the loss of MRI signal in the vessel wall and the presence of Prussian blue-stained iron colocalized with macrophages in the plaque cap, but surprisingly also with calcifying microvesicles at the intimomedial interface. Critical electrolyte magnesium chloride concentration in combination with Alcian blue stain indicates that highly sulfated glycosaminoglycans are a major constituent of these calcifying microvesicles, which may serve as the key molecules for binding VSOP due to their highly complexing properties. Conclusion: Calcifying microvesicles and macrophages are the targets for intravenously injected VSOP in atherosclerotic plaques, suggesting that VSOP-enhanced MRI may render clinically relevant information on the composition and inflammatory activity of progressive atherosclerotic lesions at risk of destabilization.

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“…administered diagnostic agents, ruling out the vast majority of applications for which nanodiagnostics are routinely employed in animal models. Among the applications for which nanodiagnostics, such as Gadomer-17 and Resovist, have been used in patients are the MR monitoring of (the perfusion of) tumor blood vessels and coronary arteries [38][39][40], the imaging of labelled stem cells [41] and the visualization of primary and/or metastatic liver lesions [42] (Figure 2G-L). A small number of additional clinical studies have focused on the use of Resovist-like iron oxide nanoparticles, such as Endorem and Sinerem, for monitoring neural stem cells [43], lymph node metastases [44], intranodally injected cancer vaccines [45], and macrophage activity in atherosclerosis [46].…”

Section: Diagnostic Nanomedicinementioning

confidence: 99%

“…from different types of sarcomas (R), thereby enabling patient preselection and (more) personalized nano-chemotherapeutic treatments. Images are adapted, with permission, from [30,[32][33][34][38][39][40][41][42][50][51][52]. Rationale for image-guided and personalized nanomedicine.…”

Section: Theranostic Nanomedicinementioning

confidence: 99%

Recent progress in nanomedicine: therapeutic, diagnostic and theranostic applications

Rizzo

Theek

Storm

et al. 2013

Current Opinion in Biotechnology

292

188

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In recent years, the use of nanomedicine formulations for therapeutic and diagnostic applications has increased exponentially. Many different systems and strategies have been developed for drug targeting to pathological sites, as well as for visualizing and quantifying important (patho-) physiological processes. In addition, ever more efforts have been undertaken to combine diagnostic and therapeutic properties within a single nanomedicine formulation. These so-called nanotheranostics are able to provide valuable information on drug delivery, drug release and drug efficacy, and they are considered to be highly useful for personalizing nanomedicine-based (chemo-) therapeutic interventions.

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Monomer-Coated Very Small Superparamagnetic Iron Oxide Particles as Contrast Medium for Magnetic Resonance Imaging

Abstract: The experiments indicate, that VSOP-C184 may be a well tolerated and safe contrast medium for MR imaging that can be effectively used for MR angiography including visualization of the coronary arteries.

Cited by 140 publications

References 39 publications

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Contrast-enhanced MR imaging of atherosclerosis using citrate-coated superparamagnetic iron oxide nanoparticles: calcifying microvesicles as imaging target for plaque characterization

Recent progress in nanomedicine: therapeutic, diagnostic and theranostic applications

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