Monolithic and Flexible Polyimide Film Microreactors for Organic Microchemical Applications Fabricated by Laser Ablation

Min, Kyoung‐Ik; Lee, Tae‐Ho; Park, Chan Pil; Wu, Zhi‐Yong; Girault, Hubert H.; Ryu, Ilhyong; Fukuyama, Takahide; Mukai, Yu; Kim, Dong‐Pyo

doi:10.1002/ange.201002004

Cited by 16 publications

(6 citation statements)

References 34 publications

(14 reference statements)

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“…In recent years, laser ablation has gained some foothold [5][6][7]in microfluidics fabrication. Advantages of laser ablation include rapid prototyping, maskless multi-level material removal, and non-contact operation.…”

Section: Introductionmentioning

confidence: 99%

Picosecond laser ablation for silicon micro fuel cell fabrication

Scotti¹,

Trusheim²,

Kanninen³

et al. 2013

J. Micromech. Microeng.

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Abstract:We have investigated laser ablation as a microfabrication approach to produce micro fuel cells (MFCs) in silicon. Picosecond pulses (15 ps) at a wavelength of 355 nm are used to make all of the MFC structures. To assess the benefits and drawbacks of laser ablation, reference cells have been produced by deep reactive ion etching (DRIE) using matching geometries. Ablated and etched cells have been evaluated and compared side by side. Our conclusion is that picosecond laser ablation is very well suited for MFC fabrication. The ablated cells match or excel DRIE-microfabricated cells in terms of current and power densities. Ablated MFCs achieved 47.6 mW cm -2 of power density and 121 mA cm -2 current density.

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Section: Introductionmentioning

confidence: 99%

Picosecond laser ablation for silicon micro fuel cell fabrication

Scotti¹,

Trusheim²,

Kanninen³

et al. 2013

J. Micromech. Microeng.

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“…4(b), the reaction for 10 min at 100 °C successfully produced the desired formylated product with 75% yield: 1 H NMR (300 MHz, CDCl 3 ) δ 7.86 (2H, J = 8.1 Hz, d), 7.25 (2H, J = 8.1 Hz, d), 2.58 (s, 3H), 2.41 (s, 3H) ppm, which is compatible with a previous report. 23 In addition, the chemical durability of the fluoropolymer film microreactor was also proven with the absence of any observable defects in the inner surface of the microchannel when continuously infused by 65% nitric acid, 40% methylamine solution and chloroform up to 1 h, respectively (refer to the ESI, † Fig. S7).…”

Section: Application For Organic Synthesis Under Various Conditionsmentioning

confidence: 94%

“…Vilsmeier-Haack formylation 23 was conducted using a mixture solution of dimethylformamide (13 eq. ), phosphoryl chloride (1.35 eq.)…”

Section: Application For Organic Synthesis Under Various Conditionsmentioning

confidence: 99%

A monolithic and flexible fluoropolymer film microreactor for organic synthesis applications

Kim

et al. 2014

Lab Chip

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A photocurable and viscous fluoropolymer with chemical stability is a highly desirable material for fabrication of microchemical devices. Lack of a reliable fabrication method, however, limits actual applications for organic reactions. Herein, we report fabrication of a monolithic and flexible fluoropolymer film microreactor and its use as a new microfluidic platform. The fabrication involves facile soft lithography techniques that enable partial curing of thin laminates, which can be readily bonded by conformal contact without any external forces. We demonstrate fabrication of various functional channels (~300 μm thick) such as those embedded with either a herringbone micromixer pattern or a droplet generator. Organic reactions under strongly acidic and basic conditions can be carried out in this film microreactor even at elevated temperature with excellent reproducibility. In particular, the transparent film microreactor with good deformability could be wrapped around a light-emitting lamp for close contact with the light source for efficient photochemical reactions with visible light, which demonstrates easy integration with optical components for functional miniaturized systems.

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“…The excellent stability of the PI chip was demonstrated by performing five chemical reactions under various harsh conditions, including acidic solvent (H 2 SO 4 /cyclohexanone oxime 1:1.5). A series of organic transformations such as Knoevenagel reaction, Vilsmeier–Haack formylation, two highly exothermic reactions for bromination of benzyl alcohol, and tin hydride mediated radical reaction at 100 °C were successfully conducted without any leaking and swelling problems …”

Section: Ultrafast Syntheses In Organic and Inorganic Chemistrymentioning

confidence: 99%

Towards Versatile Continuous‐Flow Chemistry and Process Technology Via New Conceptual Microreactor Systems

Ramanjaneyulu

Vishwakarma

Vidyacharan

et al. 2018

Bulletin Korean Chem Soc

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In the past decade, microreaction technology has been attracted much attention to the scientific community as one of the subareas in chemical synthesis. The microreactor improves the yield with higher selectivity, and also facilitates the reactions by simple, safe, fast, and green approaches. This review gives an overview on our contributions to develop versatile continuous-flow syntheses and process technology by exampling gas-liquid binary phase in modified PDMS microreactors, and process intensification for safe operation of toxic/hazardous chemistry by generating hazardous chemicals to end utilization via various separation techniques in newly devised systems as well as ordinary capillary reactors. Furthermore, it covers process technology for ultrafast organic synthesis such as submillisecond control of short-lived intermediates in a polyimide chip reactor. These works provide outlooks for integrated and automated flow chemistry via one-flow/feed to end concept, i.e., useful in pharmaceutical industry, toward enabling new and innovative chemistry beyond limits of a batch reactor.

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Monolithic and Flexible Polyimide Film Microreactors for Organic Microchemical Applications Fabricated by Laser Ablation

Abstract: Immer flexibel bleiben: Ein Mikroreaktor bestehend aus flexiblem Polyimidfilm wurde entwickelt. Er ist leichter herzustellen als Glas‐Mikroreaktoren und, anders als andere Polymermikroreaktoren, inert gegen Lösungsmittel und Säuren bei drastischen Bedingungen.

Cited by 16 publications

References 34 publications

Picosecond laser ablation for silicon micro fuel cell fabrication

Picosecond laser ablation for silicon micro fuel cell fabrication

A monolithic and flexible fluoropolymer film microreactor for organic synthesis applications

Towards Versatile Continuous‐Flow Chemistry and Process Technology Via New Conceptual Microreactor Systems

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