Monolayer kinetic model of formation of β-cyclodextrin–β-carotene inclusion complex

Ivanova, Tz.; Mircheva, Kristina; Balashev, Konstantin; Panaı̈otov, I.; Boury, Frank

doi:10.1016/j.colsurfb.2015.07.055

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…As a carrier material, β‐cyclodextrin was widely used in food and drug inclusion (Lima et al., 2016; Thongnopkoon & Chittasupho, 2018), it has a lipophilic cavity, and its diameter is suitable for nonpolar guest molecules. Furthermore, it can change the physical and chemical properties of inclusion materials and improve the solubility and stability of substances (Ivanova et al., 2015; Liu et al., 2020; Patel et al., 2015). To protect the lipophilic components that are sensitive to oxygen and light or heat‐induced degradation, cyclodextrin has been recommended for use in processing (Xie et al., 2016; Zhang et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

Preparation, optimization, characterization, and in vitro bioaccessibility of a lutein microparticle using spray drying with β‐cyclodextrin and stevioside

Dai

et al. 2020

J Food Process Preserv

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In this study, the powder of a lutein microparticle was prepared by spray drying with amphiphilic stevioside and β‐cyclodextrin as coating materials was developed to improve the solubility and bioaccessibility of lutein. Response surface methodology was used to optimize the preparation process with the drug loading capacity as index, indicating the optimal spray drying conditions were obtained as follows: feed rate of 500 ml h−1, inlet air temperature of 180°C, lutein amount of 649.4 mg, stevioside amount of 596.4 mg, and β‐cyclodextrin of 2,591.1 mg. The highest lutein loading capacity obtained was 325.7 mg g−1, resulting in high in vitro bioaccessibility of lutein (increased by twofold), which attributed to the increased solubilization capacity. The optimized lutein microparticle powders appeared spherical agglomerated structure under SEM, DSC analysis showed that the partial structure of lutein interacted with stevioside and was encapsulated by β‐cyclodextrin, FT‐IR result showed that noncovalent interactions mainly occurred between lutein and the carriers. The results suggested that the above lutein microencapsules could exhibit good potential for the bioavailability of lutein. Practical applications Lutein has widely gained considerable popularity as a food additive. To improve the solubility and bioaccessibility of lutein, lutein microparticle was successfully encapsulated with stevioside and β‐cyclodextrin by spray drying. A method for optimizing encapsulation conditions of high loading lutein microparticle powder using Box–Behnken design was studied. The result of this study can be useful for process optimization and has a significant effect on developing higher bioaccessibility for the product of lutein.

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