Monographs on fragrance raw materials

Opdyke, D.L.J.

doi:10.1016/0015-6264(73)90021-7

Cited by 18 publications

(30 citation statements)

References 2 publications

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“…It is currently being tested in clinical trials for the prevention (e.g., as a dietary supplement) and for treatment of various kinds of cancer [19,26]. Perillyl alcohol is also applied in cosmetics [32] and as synthetic precursor [28,29,43]. Because of its low natural abundance, extraction of perillyl alcohol from plant tissues only yields small amounts of the desired terpenoid [27].…”

Section: Introductionmentioning

confidence: 99%

Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C–H-oxyfunctionalization

Cornelissen

Liu

Deshmukh

et al. 2011

J Ind Microbiol Biotechnol

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Cell physiology is a critical factor determining the efficiency of reactions performed by microbial biocatalysts. In order to develop an efficient biotransformation procedure for the hydroxylation of (S)-limonene to (S)-perillyl alcohol by recombinant Pseudomonas putida cells harboring the cytochrome P450 monooxygenase CYP153A6, physiological parameters were optimized. The previously reported synthesis of (S)-perillyl alcohol by P. putida GPo12 was based on complex and sensitive octane feeding strategies (van Beilen et al. in Appl Environ Microbiol 71:1737-1744, 2005), indicating the pivotal role of cell physiology. In contrast to previous findings, the screening of different carbon sources showed that glycerol and citrate are suitable alternatives to octane allowing high specific limonene hydroxylation activities. The use of P. putida KT2440 as an alternative host strain and citrate as the carbon source improved practical handling and allowed a 7.5-fold increase of the specific activity (to 22.6 U g (CDW) (-1) ). In two-liquid-phase biotransformations, 4.3 g of (S)-perillyl alcohol L (tot) (-1) were produced in 24 h, representing a sixfold improvement in productivity compared to previously reported results. It is concluded that, for selective cytochrome P450-based hydrocarbon oxyfunctionalizations by means of living microbial cells, the relationship between cell physiology and the target biotransformation is crucial, and that understanding the relationship should guide biocatalyst and bioprocess design.

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Section: Introductionmentioning

confidence: 99%

Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C–H-oxyfunctionalization

Cornelissen

Liu

Deshmukh

et al. 2011

J Ind Microbiol Biotechnol

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“…La LD50 orale chez le rat est supé-rieure à 5 g/kg (LD50 par voie externe chez le lapin est supérieure à 10 g/kg) (34).…”

Section: Par Voie Interneunclassified

Oranger amer – Bigaradier (Rutaceae)

Ghédira

Goetz

2015

Phytothérapie

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“…Les perturbations notées sont cependant réver-sibles après arrêt du traitement. L'huile essentielle de Chenopodium ambrosioides entraine un oedème cérébral et méningé ainsi que des lésions visibles à l'autopsie [7]. L'huile essentielle de wintergreen (Gaultheria procumbens) a une toxicité (modérée cependant) quel que soit le mode d'administration en provoquant un arrêt cardiorespiratoire en surdosage [8].…”

Section: Toxicité Neurologique Des Huiles Essentiellesunclassified

États nerveux et dystonie neurovégétative, sédation avec les huiles essentielles

Goetz

2015

Phytothérapie

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Monographs on fragrance raw materials

Cited by 18 publications

References 2 publications

Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C–H-oxyfunctionalization

Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C–H-oxyfunctionalization

Oranger amer – Bigaradier (Rutaceae)

États nerveux et dystonie neurovégétative, sédation avec les huiles essentielles

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