Monographs on Endocrinology

Dale, D. G.

doi:10.1111/j.1439-0272.1973.tb00879.x

Cited by 18 publications

(2 citation statements)

References 11 publications

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“…Upregulation of the single active X in mammalian cells was proposed as a mechanism of dosage compensation between that chromosome and the pairs of autosomes 22 . Indeed, X upregulation has been observed in humans, marsupials and mice 10,23,24 .…”

Section: Chromosome Upregulationmentioning

confidence: 99%

Concurrent X chromosome inactivation and upregulation during non-human primate preimplantation development revealed by single-cell RNA-sequencing

Cidral

Mello

Gribnau

et al. 2021

Sci Rep

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In mammals, dosage compensation of X-linked gene expression between males and females is achieved by inactivation of a single X chromosome in females, while upregulation of the single active X in males and females leads to X:autosome dosage balance. Studies in human embryos revealed that random X chromosome inactivation starts at the preimplantation stage and is not complete by day 12 of development. Alternatively, others proposed that dosage compensation in human preimplantation embryos is achieved by dampening expression from the two X chromosomes in females. Here, we characterize X-linked dosage compensation in another primate, the marmoset (Callithrix jacchus). Analyzing scRNA-seq data from preimplantation embryos, we detected upregulation of XIST at the morula stage, where female embryos presented a significantly higher expression of XIST than males. Moreover, we show an increase of X-linked monoallelically expressed genes in female embryos between the morula and late blastocyst stages, indicative of XCI. Nevertheless, dosage compensation was not achieved by the late blastocyst stage. Finally, we show that X:autosome dosage compensation is achieved at the 8-cell stage, and demonstrate that X chromosome dampening in females does not take place in the marmoset. Our work contributes to the elucidation of primate X-linked dosage compensation.

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Section: Chromosome Upregulationmentioning

confidence: 99%

Concurrent X chromosome inactivation and upregulation during non-human primate preimplantation development revealed by single-cell RNA-sequencing

Cidral

Mello

Gribnau

et al. 2021

Sci Rep

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“…Additionally, the sex-linked Y and W chromosomes often undergo genetic degeneration following recombination suppression (reviewed by (21–23)), resulting in gene dose differences between males and females. Dosage compensation mechanisms have evolved in some species that increase expression levels in the heterogametic sex, potentially restoring expression to levels in the ancestral chromosome pair, and making them equal in both sexes (24–27). However, polyploidization complicates the dose differences from Y and W chromosome degeneration, and the role of polyploidization in dosage compensation is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Allopolyploidization from two dioecious ancestors leads to recurrent evolution of sex chromosomes and reversion to autosomes

He,

Wang,

Wang

et al. 2023

Preprint

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Polyploidization presents an unusual challenge for species with sex chromosomes, as it can lead to complex combinations of sex chromosomes that disrupt reproductive development. This is particularly true for allopolyploidization between species with different sex chromosome systems. Here we assemble haplotype-resolved chromosome-level genomes of a female allotetraploid weeping willow (Salix babylonica) and a male diploid Salix dunnii using Hi-C and PacBio HiFi reads. We use phylogenomics of nuclear and plastid genomes to show that weeping willow arose from crosses between female ancestor from the Salix clade, having XY sex chromosomes on chromosome 7, with a male ancestor from the Vetrix clade, having ancestral XY sex chromosomes on chromosome 15. Our analysis reveals that weeping willow has one pair sex chromosomes, ZW on chromosome 15, that derive from the ancestral XY sex chromosomes in the Vetrix-clade male ancestor, and the X chromosomes on chromosome 7 from the Salix-clade female ancestor has reverted to an autosome. Taken together, our results point to rapid evolution and reversion of sex chromosomes following allopolyploidization in weeping willow.

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Postnatal lung function in preterm lambs: Effects of a single exposure to betamethasome and thyroid hormones

Polk

Ikegami

Jobe

et al. 1995

American Journal of Obstetrics and Gynecology

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Monographs on Endocrinology

Cited by 18 publications

References 11 publications

Concurrent X chromosome inactivation and upregulation during non-human primate preimplantation development revealed by single-cell RNA-sequencing

Concurrent X chromosome inactivation and upregulation during non-human primate preimplantation development revealed by single-cell RNA-sequencing

Allopolyploidization from two dioecious ancestors leads to recurrent evolution of sex chromosomes and reversion to autosomes

Postnatal lung function in preterm lambs: Effects of a single exposure to betamethasome and thyroid hormones

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