Monofunctionalized β-cyclodextrins as sensor elements for the detection of small molecules

Macrocycleversus podant-type neutral ionophore in potentiometric detection of mucolytic agents following separation by various HPLC modes

“…The highly lipophilic mono and polyfuncfionalized c~, r162 and 7-cyclodextrins were used as oriented monolayers in chemosensors [49] and as the cation (or chiral) sensing ionophores in polymeric membrane electrodes developed for highly selective batch (static) quantitation of alkyl and arylammonium ions, acetyl choline, local anesthetics, tricyclic antidepressants as well as ephedrine and propranolol enantiomers [50]. More recently we noticed that use of trioctylated c~-cyclodextrin (CDX; Figure 2) as a component of a liquid membrane electrode improved its response during potentiometric detection of a series of cationic/~-adrenergic bronchodilators and vasodilators under cation-exchange conditions [41].…”

Synthesis of amphiphilic glycophospholipids based on β-cyclodextrins

“…The structures of isolated compounds 5a, 5b, and 6 were confirmed by the data from 1 Н, 13 С, and 31 Р NMR spectroscopy. The 1 H NMR spectrum of compound 5a contains additional signals for ethyldiisopropylamine included into the CD cavity: the broadened signal for protons of the CH 3 groups at δ 1.27 and the multiplet of protons of the CH 2 and CH groups at δ 3.18-3.22.…”

“…According to the data from 13 Р NMR spectroscopy, they appear as singlets at δ 4.6 (5a, 5b) and 53.2 (6). According to the 1 Н and 13 С NMR data, ethyldiisopropylamine is included in product 5a. The re placement of diethyl ether by toluene as a solvent resulted in inclusion of toluene in product 5a under the same conditions of synthesis and isolation.…”

“…First representa tives of a new class of amphiphilic CD based derivatives, namely, β CD bound cholesterol (A) and phospholipido cyclodextrins (B), have recently been synthesized aimed at design of fragments close in structure and nature of the lipid cholesterol matrix localized in the cell membranes. [10][11][12][13] These compounds contain hydrophobic lipid fragments conjugated with the narrow part of the CD rim, which imparts the amphiphilic properties and remains a wide part of the CD rim free for "guest" inclusion. Cholesterol was chosen as a hydrophobic residue because of its pres ence in biological membranes, due to which studies of its role and influence on the behavior of bilayers are of special interest.…”

Nanointegration: Sensor Enhancement using Nanomaterials to Detect the Pharmaceutical Residue

“…The detecting agent coupled to the trapping agent, which is embedded in a sol-type matrix. Other biological sensing elements (such as gold with trapping element such as: cyclodextrins (Janshoff et al, 2000), laccase, (Y. Liu et al, 2006), dendrimers, (Manna et al, 2001) gold-nanotubes-chitosan, (Y.…”