Monofunctional platinum(ii) dithiocarbamate complexes: synthesis, characterization and anticancer activity

Abstract

Three heteroleptic platinum(ii) dithiocarbamates with good anticancer potency have been synthesized and characterized. The anticancer activity against five cell lines may be due to their strong complex-DNA adduct formation ability.

Synthesis, characterization and anti-cancer studies of Mn(II), Cu(II), Zn(II) and Pt(II) dithiocarbamate complexes - crystal structures of the Cu(II) and Pt(II) complexes

“…Metal dithiocarbamates have been shown to possess promising biological activities [16,17]. Recent studies have shown that metal dithiocarbamates bind DNA in different ways, with varying cytotoxic activities [3,[18][19][20][21][22][23][24][25]. They inhibit NF-kB, which is known to promote tumor cell proliferation [26][27][28].…”

Pentafluorophenyl Platinum(II) Complexes of PTA and Its N-Allyl and N-Benzyl Derivatives: Synthesis, Characterization and Biological Activity

“…An approach to circumvent cross-resistance is to change the functionality on the metal center namely by decreasing the number of available coordination sites. Monofunctional complexes can be active [57,58,59,60] and have the advantage of having ancillary ligands, which, as such, modify sterically and electronically the behavior of the resulting complex.…”

Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological

“…Several pharmacological applications of dithiocarbamate compounds have been popularized scientifically in recent decades. Due to the chemical and structural flexibility of these compounds, their use has been widely investigated as anti-carcinogenic agents [66,67,68,69,70,71,72,73,74,75,76,77], antibacterial [78,79], antiviral [80,81], antifungal [82,83], among others. In this review, we have presented and discussed the different applications of these compounds as potential antiparasitic compounds, more specifically as antitrypanosomatids-drugs against Chagas disease, leishmaniasis, and African trypanosomiasis.…”