Monodispersed Molecularly Imprinted Polymer for Creatinine by Modified Precipitation Polymerization

Molecularly imprinted polymer for chlorogenic acid by modified precipitation polymerization and its application to extraction of chlorogenic acid from Eucommia ulmodies leaves

“…MIPs for CGA and non-imprinted polymers (NIPs) were prepared by a modified precipitation polymerization method as previously reported [20,21], as shown in Table 1. Briefly, CGA (1.5 mmol) dissolved in 1.0 and 0.5 mL of methanol (MeOH) and 1.0 mL of dimethylsulfoxide (DMSO), respectively, as a template molecule, MAA (6 mmol) as a functional monomer, DVB (28.8 mmol) as a crosslinker and AIBN (1.9 mmol) as an initiator were added in 128 mL of acetonitrile-toluene (3/1, v/v).…”

“…Previously, we prepared a monodisperse MIP for creatinine by modified precipitation polymerization [20,21]: creatinine was first dissolved in a small portion of water, and then a MIP for creatinine was prepared by precipitation polymerization. Three MIPs for CGA, which is hydrophilic, were prepared using MeOH or DMSO as a co-solvent for dissolving a template molecule, CGA, by modified precipitation polymerization.…”

“…Recently, we prepared a monodisperse MIP for creatinine by modified precipitation polymerization [20,21]. Because creatinine is hydrophilic, it does not dissolve in porogenic solvents.…”

“…The use of water to dissolve creatinine distinguished this method from other precipitation polymerizations. The method was called modified precipitation polymerization [20,21]. CGA did not dissolve in porogenic solvent, a mixture of acetonitrile and toluene.…”

Designing and controlling the morphology of spherical molecularly imprinted polymers

“…For some hydrophilic templates, modified precipitation polymerization can be adopted. 28,29 In this method, the hydrophilic template is first dissolved in a small portion of water, and then MIPs are prepared by precipitation polymerization using acetonitrile or toluene as solvent.…”