Monodispersed and Ordered Large‐Pore Mesoporous Silica Nanospheres with Tunable Pore Structure for Magnetic Functionalization and Gene Delivery

Abstract

It can be larger: A facile self-assembly/solvothermal approach to synthesize monodispersed, large-pore (>12 nm) silica nanospheres (LPSNs) with ordered, accessible, and interconnected pore channels has been successfully developed by utilizing an amphiphilic block copolymer (polystyrene-b-poly (acrylic acid), PS-b-PAA) as pore template and cetyltrimethylammonium bromide (CTAB) as structure-stabilizing agent.

Facile Synthesis of Yolk-Shell-Structured Triple-Hybridized Periodic Mesoporous Organosilica Nanoparticles for Biomedicine

“…The FT-IR spectrum of the PMO nanoparticles displays the characteristic C-H vibration peak at 1414 cm -1 from CH 2 -CH 2 moiety, [ 35 ] the C-H vibration peak at 1153 cm -1 from benzene ring, [ 41 ] the C-S absorbance band at 694 cm -1 from thioether group, [ 42 ] and the Si-O-Si band at 900-1300 cm -1 ( Figure 2 a), [ 47 ] suggesting that the ethane, benzene, and thioether groups had condensed in the yolk-shell-structured PMO nanoparticles. The 29 Si magic-angle spinning (MAS) nuclear magnetic resonance (NMR) spectrum of the yolkshell-structured triple-hybridized PMO nanoparticles shows two large peaks at −67 and −58 ppm, corresponding to T 3 (C-Si (OSi) 3 ) and T 2 (C-Si (OSi) 2 (OX), X = H or Et) species (Figure 2 b), [ 35,44 ] clearly suggesting the organosilica frameworks. Simultaneously, two small signals at −109 and −101 ppm, corresponding to Q 4 ( Si (OSi) 4 ) and Q 3 ( Si (OSi) 3 (OX)) species, [ 17,24 ] are also observed in the NMR spectrum due to the introduction of TEOS.…”

“…[15][16][17][18][19][20][21] However, the Si-O-Si frameworks of mesoporous silica still have some limitations and drawbacks in the biobehaviors and performance, and their medical translation is still a big challenge. The periodic mesoporous organosilicas (PMOs) prepared by using bridged silsesquioxane with the type of (R′O) 3 Si-R-Si(R′O) 3 as precursors provide organic groups homogeneously incorporated frameworks. [22][23][24][25][26][27][28][29] The organic groups incorporated in the frameworks can greatly change the properties of mesoporous siliceous nanoparticles and endow them with better performance in biomedical applications.…”

Hierarchical mesoporous silica nanoparticles for tailorable drug release

“…Owing to their unique advantages including well-defined morphology, uniform size, controllable structure, super high specific pore volume, tunable pore size, easily modified surface, high drug-loading capacity, and excellent biocompatibility, mesoporous silica nanoparticles (MSNs) have attracted increasing interest in biomedical applications in the recent decades, especially in controlled drug delivery system (Berger et al, 2016;Chen et al, 2013a;Chen et al, 2014;Chen et al, 2013b;Chin et al, 2014;Ge et al, 2015;Jia et al, 2015;Kim et al, 2015;Knežević et al, 2013;Li et al, 2011;Mamaeva et al, 2013;Niu et al, 2014;Tang and Cheng, 2013;Tao, 2014;von Haartman et al, 2013;. However, the simplex structure of MSNs is barely able to meet the demands of drug release in complicated in vivo environment.…”

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

“…On this topic, Shi and co-workers reported the preparation of MSNs with different morphologies (hexagonal, cubic, lamellar and flower-like) but with common 12nm size mesopores for transfection purposes. 110 Although they made only the in vitro evaluation with the GFP plasmid and VEFG siRNA only with the spherical particles, completely bypassing the comparison between the different morphologies. Fortunately, contributions from other research groups have reported the use of other structures for this application.…”