Monodisperse water-in-oil-in-water emulsions generation for synthesising alginate hydrogel microspheres via locally hydrophobic modification to PMMA microchannels

Ding, Li; Li, Xiaoping; Chen, Chuan; Zheng, Zongwei; Chang, Honglong

doi:10.1016/j.snb.2017.08.152

Cited by 18 publications

(11 citation statements)

References 41 publications

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“…Additionally, the microfluidic reactor should overcome the limitations of traditional methods of transporting fluids in microchannels using external pressure and electric fields 22,23 . Generally, a microfluidic reactor requires a microsyringe pump to tune the fluid flow direction and regulate the adjusted volumetric flows 24 . In particular, it takes a relatively long time to derive such a steady-state flow of a variety of viscous fluids by inducing conventional pumping methods, and has limitations to connect to a continuously expandable mass-production of a wide range of customized smart materials 25–27 .…”

Section: Introductionmentioning

confidence: 99%

Centrifugal Force-Driven Modular Micronozzle System: Generation of Engineered Alginate Microspheres

Kang

Lee

Huh

2019

Sci Rep

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In this study, we developed a modular micronozzle system that can control the flow of fluid based on centrifugal force and synthesize functional alginate microspheres with various structures and sizes. Our method is to fabricate a programmable microreactor that can be easily manufactured without the conventional soft-lithography process using various sequences of the micronozzles with various inner diameters. To overcome the obstacles of pump-based microfluidic devices that need to be precisely controlled, we designed the programmable microreactor to be driven under centrifugal force with a combination of micronozzles, thus enabling the mass production of various functional alginate microspheres within a few minutes. The programmable microreactor designed through the arrangement of the modular micronozzles enables the formation of various types of alginate microspheres such as core-shell, Janus, and particle mixture. These materials are controlled to a size from 400 µm to 900 µm. In addition, our platform is used to generate pH-responsive smart materials, and to easily control various sizes, shapes, and compositions simultaneously. By evaluating the release process of model drugs according to the pH change, the possibility of drug delivery application is confirmed. We believe that our method can contribute to development of biomaterials engineering that has been limited by the requirement of sophisticated devices, and special skills and/or labor.

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Section: Introductionmentioning

confidence: 99%

Centrifugal Force-Driven Modular Micronozzle System: Generation of Engineered Alginate Microspheres

Kang

Lee

Huh

2019

Sci Rep

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“…In order to generate double or multiple emulsions, local surface modifications are essential to produce stable single emulsions at the different junctions. Li et al [122] proposed a locally hydrophobic modification strategy for producing W/O/W double emulsion in PMMA chips. The chip consisted of two flow focusing units, the first of which was used to generate W/O emulsions, while the second was hydrophobically modified via PDMS injection coating to generate double emulsions.…”

Section:  Advanced Surface Modification Of Microchannelmentioning

confidence: 99%

Advanced microfluidic devices for fabricating multi‐structural hydrogel microsphere

Chen

Zhang

et al. 2021

Exploration

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Hydrogel microspheres are a novel functional material, arousing much attention in various fields. Microfluidics, a technology that controls and manipulates fluids at the micron scale, has emerged as a promising method for fabricating hydrogel microspheres due to its ability to generate uniform microspheres with controlled geometry. With the development of microfluidic devices, more complicated hydrogel microspheres with multiple structures can be constructed. This review presents an overview of advances in microfluidics for designing and engineering hydrogel microspheres. It starts with an introduction to the features of hydrogel microspheres and microfluidic techniques, followed by a discussion of material selection for fabricating microfluidic devices. Then the progress of microfluidic devices for single-component and composite hydrogel microspheres is described, and the method for optimizing microfluidic devices is also given. Finally, this review discusses the key research directions and applications of microfluidics for hydrogel microsphere in the future.

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“…Furthermore, diameters of these droplets can be adjusted and the size of the fabricated droplets ranged from tens to hundreds of micrometers, which greatly contributes to droplets' manipulation and analyzing applications. A flow‐focusing microfluidic device, consisting of double cross‐junctions, for the high‐throughput production of monodisperse water‐in‐oil‐in‐water (W/O/W) emulsions was described . Both the sizes and the number of inner droplets are all controllable for the generated W/O/W emulsions.…”

Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 99%

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

Small

116

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Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the subcategories of biomimetic materials, artificial cells are highly significant for multiple disciplines and their synthesis has been intensively pursued. In order to manufacture robust “alive” artificial cells with high throughput, easy operation, and precise control, flexible microfluidic techniques are widely utilized. Herein, recent advances in microfluidic‐based methods for the synthesis of droplets, vesicles, and artificial cells are summarized. First, the advances of droplet fabrication and manipulation on the T‐junction, flow‐focusing, and coflowing microfluidic devices are discussed. Then, the formation of unicompartmental and multicompartmental vesicles based on microfluidics are summarized. Furthermore, the engineering of droplet‐based and vesicle‐based artificial cells by microfluidics is also reviewed. Moreover, the artificial cells applied for imitating cell behavior and acting as bioreactors for synthetic biology are highlighted. Finally, the current challenges and future trends in microfluidic‐based artificial cells are discussed. This review should be helpful for researchers in the fields of microfluidics, biomaterial fabrication, and synthetic biology.

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Monodisperse water-in-oil-in-water emulsions generation for synthesising alginate hydrogel microspheres via locally hydrophobic modification to PMMA microchannels

Cited by 18 publications

References 41 publications

Centrifugal Force-Driven Modular Micronozzle System: Generation of Engineered Alginate Microspheres

Centrifugal Force-Driven Modular Micronozzle System: Generation of Engineered Alginate Microspheres

Advanced microfluidic devices for fabricating multi‐structural hydrogel microsphere

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

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