Monodisperse selenium-substituted hydroxyapatite: Controllable synthesis and biocompatibility

Selenium-Doped Hydroxyapatite Nanocrystals–Synthesis, Physicochemical Properties and Biological Significance

“…Samples of SeO 3 -HA obtained by the solvothermal method, with 15-40% of the phosphate ions being exchanged for selenite, have reflections typical of HA [35]. In the sample with 55% P exchanged for Se, additional reflections were noted from the calcium selenite [35].…”

“…HA doped with selenium ions can be obtained in two ways: through synthesis, during which ions are incorporated into the HA structure [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47], or by ion exchange, where soaking in a selenium salt solution results in the exchange of ions in the HA structure [47].…”

“…The obtained powders contained various amounts of selenium [33][34][35][36][37][38][39][40][41][42][43][44][45][46][47], most often up to 10% by weight [33,36,37,40,41,43,44,46]. It should be noted that the reaction efficiency was often lower than 100% [33,36,40,41,43,44,46].…”

“…The precipitated crystals were treated hydrothermally for 36 h at 160 • C. By so doing, selenium ions were incorporated in a molar ratio of Se:P ranging from 0.001 to 0.421 [42]. The solvothermal method of heating for 10 h at 120 • C was also applied by Sun et al [35]. The reaction was carried out in a Teflon-lined reactor with the addition of PEG 20000 and oleic acid in substrate proportions that allowed a series of samples to be obtained that contained between 0% and 55% of phosphate ions replaced with selenite ions [35].…”

“…The solvothermal method of heating for 10 h at 120 • C was also applied by Sun et al [35]. The reaction was carried out in a Teflon-lined reactor with the addition of PEG 20000 and oleic acid in substrate proportions that allowed a series of samples to be obtained that contained between 0% and 55% of phosphate ions replaced with selenite ions [35]. In the studies [33,37,40], a dispersion agent was used in the wet method in the form of either sodium polyacrylate [37,40] or PEG [33].…”