Monodisperse porous poly(vinyl acetate-co-divinylbenzene) particles by single-stage seeded polymerization: A packing material for reversed phase HPLC

Caglayan, Berna; Unsal, Ender; Camli, Sevket Tolga; Tuncel, Mürvet; Tuncel, Alï

doi:10.1002/jssc.200500499

Cited by 15 publications

(6 citation statements)

References 38 publications

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“…The slopes between 0.10 and 0.19 were obtained with different ACN concentrations, and the slope increased with increasing ACN concentration. The results are in accordance with the methylene selectivity range of silica-based and polymer-based reversedphase columns [31][32][33]. The results indicated that separation power of poly(GDMA-co-GDGDA) column increased with decreasing ACN concentration in the mobile phase.…”

Section: Chromatographysupporting

confidence: 78%

A simple synthetic route for the preparation of a reversed-phase stationary phase based on monosized-porous hydrogel beads and its chromatographic use for separation of small molecules

Çelebі

2017

Acta Chromatographica

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Summary. New polyacrylate-based monosized-porous polymer beads were proposed as a stationary phase for the separation of polar compounds by microbore reversed-phase chromatography. For this purpose, monosized-porous poly(glycerol dimethacrylate-coglycerol-1,3-diglycerolate diacrylate), poly(GDMA-co-GDGDA), beads with hydroxyl functionality were synthesized by a modified seeded polymerization. The selected octadecylating agent, stearoyl chloride (SC), was covalently attached onto the hydrophilic beads via a direct, single stage reaction with a simple synthetic route. SC attachedpoly(GDMA-co-GDGDA) beads were slurry-packed into the microbore columns and used as separation medium microbore reversed-phase chromatography. The stationary phase was used for separation of alkylbenzenes and polar analytes by micro reversedphase chromatography, using mobile phases with low acetonitrile content. Theoretical plate number (TPN) values up to 12,000 plates m −1 and 10,000 plates m −1 for alkylbenzenes and polar analytes, respectively, were achieved. The results also showed that poly(GDMA-co-GDGDA) hydrogel beads are a promising starting material for a number of chromatographic applications like reversed-phase (RP) chromatography, hydrophilic interaction chromatography (HILIC), ion-exchange chromatography (IEC), and affinity chromatography with a single-stage surface modification.

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Section: Chromatographysupporting

confidence: 78%

A simple synthetic route for the preparation of a reversed-phase stationary phase based on monosized-porous hydrogel beads and its chromatographic use for separation of small molecules

Çelebі

2017

Acta Chromatographica

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“…A single‐step swelling method optimized from the method proposed by Caglayan29 was chosen for preparation of poly(DVB), poly(VAc‐ co ‐DVB), poly(EDMA), and poly(GMA‐ co‐EDMA) particles. In general, a homogeneous organic phase was obtained by admixing the monomer mixture with toluene‐containing BPO initiator (Tables 2 and 3).…”

Section: Methodsmentioning

confidence: 99%

The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization

Yau

Yao

Chan

et al. 2009

Cancer

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Objective To investigate whether patients with idiopathic recurrent acute anterior uveitis (AAU) have enthesis alterations comparable with those in patients with spondylarthritis (SpA). Methods A blinded, controlled study of enthesis evident on ultrasound (US) examination was performed in 100 patients and controls classified into 5 groups, as follows: patients with confirmed SpA (group 1), patients with recurrent AAU who were positive for HLA–B27 and did not have SpA (group 2), patients with recurrent AAU who were negative for HLA–B27 and did not have SpA (group 3), patients with forms of uveitis other than those related to SpA (group 4), and healthy controls (group 5). In total, 12 enthesis locations were explored in each patient and control subject by 2 ultrasonographers who were blinded with regard to the diagnosis. A newly developed US method, the Madrid Sonography Enthesitis Index (MASEI), in which the diagnosis of SpA is determined as a cutoff score of 18 points, was used. Results A total of 1,200 entheses were explored by US in 100 patients and controls. The MASEI cutoff limit was met or exceeded by 81%, 55.6%, 40%, 10%, and 19% of the subjects in the 5 groups, respectively. The MASEI score was significantly higher in groups 1 and 2 than in groups 4 and 5. The differences between groups 1 and 3 were also found to be significant. Conclusion Our findings indicate that a high percentage of HLA–B27–positive patients with idiopathic recurrent AAU without features of SpA have enthesis lesions comparable with those seen in patients with SpA. These data suggest that patients with recurrent AAU, especially those who are HLA–B27 positive, have an abortive or incomplete form of SpA.

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“…Since emulsion prepared seeds are generally in the submicron range, they are suitable for obtaining particles up to 10 µm in diameter after the suspension polymerization stage [68][69]. On the other hand, dispersion polymerized seeds can be in the range of 1-20 µm, thus 10-200 µm particles can be obtained in the suspension polymerization stage [70][71][72][73][74][75][76][77][78][79]. Note that a volume enlargement of 10 6 times would be needed for a 1 µm seed to be swollen by the new monomer(s) to 100 µm.…”

Section: Seeded Suspension Polymerizationmentioning

confidence: 99%

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

Gökmen

Prez

2012

Progress in Polymer Science

446

309

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Monodisperse porous poly(vinyl acetate-co-divinylbenzene) particles by single-stage seeded polymerization: A packing material for reversed phase HPLC

Cited by 15 publications

References 38 publications

A simple synthetic route for the preparation of a reversed-phase stationary phase based on monosized-porous hydrogel beads and its chromatographic use for separation of small molecules

A simple synthetic route for the preparation of a reversed-phase stationary phase based on monosized-porous hydrogel beads and its chromatographic use for separation of small molecules

The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization

Porous polymer particles—A comprehensive guide to synthesis, characterization, functionalization and applications

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