Monodisperse particle production: A method to prevent drop coalescence using electrostatic forces

Brandenberger, Harry R.; Nüssli, D.; Piëch, V.; Widmer, Fritz

doi:10.1016/s0304-3886(98)00052-7

Cited by 80 publications

(37 citation statements)

References 15 publications

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“…This technique, the characterization of which has been reported elsewhere (Brandenberger et al 1998), enables the production of greater than 10 mL of monodisperse capsules min ¡ 1 (size distribution < 3% using a 300 mm nozzle) under completely sterile conditions. All steps in the capsule-forming process, including bead formation, membrane coating and washing steps, may be performed in the same autoclavable encapsulator vessel.…”

Section: Microencapsulation Devicementioning

confidence: 99%

Quantitative study of the production and properties of alginate/poly-L-lysine microcapsules

Gügerli

Cantana

Heinzen

et al. 2002

Journal of Microencapsulation

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Alginate-polylysine-alginate (APA) microcapsules are of particular interest for their application as implants or for bioreactor cultures. Although their formation has been widely studied, there is still a lack of quantitative data describing resistance, membrance thickness and permeability. In this study, the quantitative application of a Texture Analyser for the measurement of capsule deformation yielded important results that permit comparison with other polymer systems used for encapsulation. Furthermore, single-membrane and multi-membrane capsules were formed in order to improve the modulation of the capsule properties. For single-membrane capsules, resistance was mostly a ected by the incubation time in poly-l-lysine (PLL), the PLL molecular weight and concentration. The increase in resistance from 0:1 § 0:01 g/capsules to 2 § 0:2 g/capsules was linked to a membrane thickening (35±120 mm) and a decrease in permeability (150 to 40 kD). Thus, it was not possible to modify resistance and membrane permeability independently. Multi-membrane capsules with a resistance comparable to single-membrane capsules could be formed using various combinations of PLL molecular weights, and enabled uncoupling of permeability and resistance properties.

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Section: Microencapsulation Devicementioning

confidence: 99%

Quantitative study of the production and properties of alginate/poly-L-lysine microcapsules

Gügerli

Cantana

Heinzen

et al. 2002

Journal of Microencapsulation

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“…In the above system, this effect is accomplished by electrostatic repulsion forces system. It was first introduced by Brandenberger et al [14]. Electrostatic field right after break-up charges the droplets and because of this fact -agglomeration effect is eliminated.…”

Section: Vibration Jet Systemmentioning

confidence: 99%

“…Thanks to dispersion, microcapsules are distributed over a large surface of hardening bath, which results in monodispersed beads [12]. According to Brandenberger et al, the electrode potential is supposed to be in the range of 400-2500 V, which is strictly connected with the droplet diameter and jet velocity [14].…”

Section: Vibration Jet Systemmentioning

confidence: 99%

Wytwarzanie homo- i heterogenicznych mikrokapsułek oraz ich zastosowanie

Semba

Trusek-Hołownia

2017

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Microencapsulation is defined as a process during which the whole envelopment with (bio)catalysts, substrates etc. is included into hydrogel and/or surrounded by a porous polymeric membrane. However, the production of homogeneous, narrow size, distributed capsules is quite troublesome. The main problem is the way of obtaining a large number of capsules with a precisely predefined size. It is possible due to a device called an encapsulator. This equipment allows to produce homogeneous beads and core-shell systems with a predefined size in the range from 400 µm to 1600 µm, which is possible because of special nozzles with different diameters. There are a lot of microcapsule applications. In this paper, we would like to present the construction, principles of operation and selected applications of microencapsulation devices using the example of the BÜCHI-B390 encapsulator.Keywords: microencapsulation; homogeneous beads; core-shell systems; encapsulator BÜCHI-B390 Streszczenie Mikrokapsułkowanie definiowane jest jako proces, w którym całe środowisko zawierające m.in. (bio)katalizatory, substraty itp. zamykane jest w sieci hydrożelu i/lub otaczane porowatą polimerową membraną. Wytwarzanie jednorodnych kapsułek o wąskim rozkładzie wielkości jest dość kłopotliwe. Głównym problemem do rozwiązania jest sposób uzyskania dużej liczby kapsułek o dokładnie zdefiniowanej wielkości. Jest to możliwe przy użyciu urządzenia zwanego enkapsulatorem. Pozwala ono na wytwarzanie homogenicznych kapsułek i układów rdzeń-powłoka o zdefiniowanej wielkości w zakresie od 400 µm do 1600 µm, co jest możliwe za pomocą zestawu dysz o różnych średnicach. Istnieje wiele aplikacji mikrokapsułek. W artykule przedstawiona zostanie budowa, zasada działania i wybrane zastosowania urządzenia do mikroenkapsulacji na przykładzie enkapsulatora BUCHI-B390.Słowa kluczowe: mikroenkapsulacja; homogeniczne mikrokapsułki; układy rdzeń-powłoka; enkapsulator BÜCHI-B390

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“…Monodisperse alginate beads were prepared using an encapsulation device based on a vibrating-nozzle (Encapsulator Research Inotech, Dottikon Switzerland) and the experimental procedure described elsewhere [9]. This system is composed ( Figure 1) of a 2-liter glass reaction vessel with stainless steel top and bottom plates.…”

Section: Production Of Alginate Microcapsules By a Vibrating-nozzle Pmentioning

confidence: 99%

Production and Characterization of Alginate Microcapsules Produced by a Vibrational Encapsulation Device

et al. 2008

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The optimization, through a Design of Experiments (DoE) approach, of a microencapsulation procedure for isolated neonatal porcine islets (NPI) is described. The applied method is based on the generation of monodisperse droplets by a vibrational nozzle. An alginate/polyornithine encapsulation procedure, developed and validated in our laboratory for almost a decade, was used to embody pancreatic islets. We analyzed different experimental parameters including frequency of vibration, amplitude of vibration, polymer pumping rate, and distance between the nozzle and the gelling bath. We produced calcium-alginate gel microbeads with excellent morphological characteristics as well as a very narrow size distribution. The automatically produced microcapsules did not alter morphology, viability

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Monodisperse particle production: A method to prevent drop coalescence using electrostatic forces

Cited by 80 publications

References 15 publications

Quantitative study of the production and properties of alginate/poly-L-lysine microcapsules

Quantitative study of the production and properties of alginate/poly-L-lysine microcapsules

Wytwarzanie homo- i heterogenicznych mikrokapsułek oraz ich zastosowanie

Production and Characterization of Alginate Microcapsules Produced by a Vibrational Encapsulation Device

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