Monodisperse mesoporous cobalt ferrite nanoparticles: synthesis and application in targeted delivery of antitumor drugs

Mohapatra, Sasmita; Rout, Smruti R.; Maiti, Swatilekha; Maiti, Tapas K.; Panda, Asit Baran

doi:10.1039/c1jm10732a

Cited by 110 publications

(54 citation statements)

References 51 publications

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“…Thus, CFO NPs embedded in PMA-co-PHEMA were noncytotoxic for the cells. Similar noncytotoxicity has been reported for CoFe 2 O 4 nanoparticles [33,34].…”

Section: Magnetic Propertiessupporting

confidence: 78%

In situ synthesis of cobalt ferrite nanoparticle/polymer hybrid from a mixed Fe–Co methacrylate for magnetic hyperthermia

Hayashi

Maeda

Moriya

et al. 2012

Journal of Magnetism and Magnetic Materials

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“…Thus, CFO NPs embedded in PMA-co-PHEMA were noncytotoxic for the cells. Similar noncytotoxicity has been reported for CoFe 2 O 4 nanoparticles [33,34].…”

Section: Magnetic Propertiessupporting

confidence: 78%

In situ synthesis of cobalt ferrite nanoparticle/polymer hybrid from a mixed Fe–Co methacrylate for magnetic hyperthermia

Hayashi

Maeda

Moriya

et al. 2012

Journal of Magnetism and Magnetic Materials

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“…There were no significant statistical differences (P>0.05) between the effects of MTX and MMCMs (C/M) in the S phase, which indicated that MMCMs (C/M) did not decrease efficacy and arrest the cell cycle in the S phase. As demonstrated by other published data, MTX is an S phase specific drug, which generally produces growth arrest in the S phases of the cell cycle [39].…”

Section: The Effect Of Mmcms (C/m) On the Mg-63 Cell Cyclementioning

confidence: 89%

The in vitro and in vivo anti-tumor effects of MTX-Fe3O4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2

Chen

Ting-ting

Wang

et al. 2014

Sci. China Life Sci.

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The in vitro and in vivo anti-tumor efficacy of methotrexate-loaded Fe 3 O 4 -poly-L-lactide-poly(ethylene glycol)-poly-L-lactide magnetic composite microspheres (MTX-Fe 3 O 4 -PLLA-PEG-PLLA MCMs, MMCMs), which were produced by co-precipitation (C) and microencapsulation (M) in a supercritical process, was evaluated at various levels: cellular, molecular, and integrated. The results at the cellular level indicate that MMCMs (M) show a better anti-proliferation activity than raw MTX and could induce morphological changes of cells undergoing apoptosis. At the molecular level, MMCMs (M) lead to a significantly higher relative mRNA expression of bax/bcl-2 and caspase-3 than MMCMs (C) at 10 µg mL 1 (P<0.01); and the pro-caspase-3 protein expression measured by Western blot analysis also demonstrates that MMCMs (M) can effectively activate pro-caspase-3. At the integrated level, mice bearing a sarcoma-180 tumor are used; in vivo anti-tumor activity tests reveal that MMCMs (M) with magnetic induction display a much higher tumor suppression rate and lower toxicity than raw MTX. Pharmacokinetic studies show that MMCMs (M) with magnetic induction significantly increase the accumulation of MTX in the tumor tissue compared with the other treatments. These results suggest that the MMCMs (M) prepared by the SpEDS process have great potential to play a positive role in the magnetic targeted therapy field.

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“…Another kind of MNPs of mesoporous cobalt ferrite (CoFe 2 O 4 ) decorated with FA has been encapsulated with methotrexate and DOX (anti-cancer drugs). The drug-loaded NPs exhibited cytotoxicity and induced apoptosis in HeLa cells demonstrating their role as drug delivery vehicles (Mohapatra et al 2011). Multi-functional SiO 2 NPs have been surface modified with PEG and functionalized with adamantine and FA.…”

Section: Targeted Deliverymentioning

confidence: 99%

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

Singla

Guliani

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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The metallic nanoparticles (NPs) and their synthetic biology are an active area fascinating both the academics as well as scientific research applications in the field of nanotechnology. These nanostructures are a versatile class of materials such as metal NPs, metal oxide NPs, magnetic NPs and quantum dots for biomedical sciences and engineering due to their huge potential. A handful number of methods are adopted for the synthesis of one or the other kind of metal NPs which includes physical and chemical approaches. Each of the chemical and physical synthesis procedures deals with some limitations such as cost ineffectiveness, use of hazardous chemicals, formation of toxic end products and involvement of high-energy processes. To overcome these drawbacks, an alternative approach of environmentally benign and inexpensive biological synthesis mediated by plants or microbes has been essentially adopted. The variations in size, shape and surface chemistry of NPs affect the properties of metal NPs to a greater extent which in turn have an influence on their biological behaviour. Few metal NPs offer unique optical properties while others possess paramagnetic behaviour and quantum size effect which make them suitable in bio-imaging diagnostic techniques. Some metallic NPs play a role in tissue engineering and other therapeutic applications due to their ease of surface modifications, large surface area to volume ratio, unique electrical and anti-microbial activities. Instead of multi-disciplinary applications of metallic NPs, there is a great concern regarding the toxicity issues associated with the use of these NPs which need to be sorted out by looking out certain ways for favourable architecture involving the synthesis methods and parameters for designing the non-toxic NPs for improving the quality of life.

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Monodisperse mesoporous cobalt ferrite nanoparticles: synthesis and application in targeted delivery of antitumor drugs

Cited by 110 publications

References 51 publications

In situ synthesis of cobalt ferrite nanoparticle/polymer hybrid from a mixed Fe–Co methacrylate for magnetic hyperthermia

In situ synthesis of cobalt ferrite nanoparticle/polymer hybrid from a mixed Fe–Co methacrylate for magnetic hyperthermia

The in vitro and in vivo anti-tumor effects of MTX-Fe3O4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

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