Monocytoid B-cell lymphoma in patients with Sjögren's syndrome: A clinicopathologic study of 13 patients

Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

“…Nonetheless, despite these similarities, there is a striking difference between thymic MALT lymphoma and other SS-associated MZBL: 13 of 15 cases (87%) of thymic MALT lymphoma show an IgA phenotype, whereas SS-associated nonthymic MZBLs have been reported to express exclusively an IgM phenotype. [37][38][39][40] IgA phenotype is also commonly observed in thymic MALT lymphomas reported from the West; two of the four such cases have expressed IgA phenotype. 14,20 This IgA expression also discriminates thymic MALT lymphoma from nonthymic MALT lymphomas, which typically express IgM, and less often IgG or IgA.…”

“…In their series, one thymic MALT lymphoma case arose concurrently with salivary and gastric MALT lymphomas. Shin and colleagues 38 described the clinicopathological features of 13 SS patients with monocytoid B-cell lymphoma (MZBL) of either nodal or extranodal origin. Combining the clinical profile of the SS patients with MZBLs from these two reports, the mean age was 58 years, there was marked female predilection (male:female ϭ 1:7.3), and the SS diagnosis was established 8.2 years before the diagnosis of MZBL.…”

API2-MALT1 Fusion Defines a Distinctive Clinicopathologic Subtype in Pulmonary Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue

“…Indeed, a high frequency of pre-existing autoimmune disorders or predisposing inflammatory stimuli have been observed in patients with extranodal MALT lymphomas, including Sjogren's syndrome, Hashimoto's thyroiditis, and H. pylori gastritis, and a pre-existing chronic inflammation has been established as a critical risk factor for developing malignant lymphoma. 3,42,43 It is worth noting that a low frequency (less than 4%) of API2-MALT1 fusion has been reported for MALT lymphomas of the salivary glands and thyroid, 9,13,37 where autoimmune disease plays an important role in their development. In addition, we recently reported the absence of API2-MALT1 fusion in thymic MALT lymphoma that is closely associated with autoimmune disease.…”

Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

“…Although many reports have substantiated the link between Sjogren's syndrome and lymphoma development (Shin et al, 1991;Pavlidis et al, 1992), the exact prevalence of lymphomas and the actual relative risk are still not known. Anecdotal reports from around the world would suggest that the risk varies from population to population and may depend on diagnostic criteria and the length of follow-up of individual patients.…”