Monocytic Chemotactic Protein-1 in Physiology and Medicine (Review of Literature)

Kolotov, K. A.; Анатольевич, Колотов Константин; Rasputin, Pavel; Геннадьевич, Распутин Павел

doi:10.17816/pmj35399-105

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Последний является мощнейшим хемоаттрактантом для моноцитов и макрофагов и активно синтезируется этими же клетками, а также эндотелио-и кардиомиоцитами, фибробластами и др. [6,13,25]. Кроме того, МСР-1 выступает провоспалительным медиатором, индуцирующим инсулинорезистентность тканей [25], поэтому рост его концентрации в крови определен у больных ИБС без кардиомиопатии (см.…”

Section: Original Studiesunclassified

“…[6,13,25]. Кроме того, МСР-1 выступает провоспалительным медиатором, индуцирующим инсулинорезистентность тканей [25], поэтому рост его концентрации в крови определен у больных ИБС без кардиомиопатии (см. табл.…”

Section: Original Studiesunclassified

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Blood monocytes in maintaining the balance of vascular endothelial injury and repair process in ischemic cardiomyopathy

Chumakova

Уразова

Denisenko³

et al. 2022

Kompleks. probl. serdečno-sosud. zabol.

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Highlights. The features of subsets of monocytes in combination with the levels of desquamated endotheliocytes, endothelial damage and regeneration mediators and progenitor cell migration-enhancing factors in patients with coronary heart disease and with/without ischemic cardiomyopathy were analyzed. For the first time it was shown that in patients with ischemic cardiomyopathy, compared with CHD patients without cardiomyopathy, higher desquamation of the endothelium is associated with a deficiency of non-classical monocytes and reduced migration of progenitor endothelial cells (VEGFR2+-monocytes) with regenerative potential across the bone marrow due to a deficiency of the HIF-1α mediator in the blood.Background. The development of ischemic cardiomyopathy (ICM) is an understudied process, and one of its elements may be insufficient regeneration of blood vessels due to an imbalance of subsets of monocytes in the blood.Aim. To assess subsets of monocytes and desquamated endothelial cells in combination with endothelial damage and regeneration mediators in the blood of patients with coronary heart disease (CHD) and with/without ICM.Methods. The study included 30 patients with ICM, 22 patients with coronary heart disease without cardiomyopathy aged 55–69 years, and 18 healthy donors. In whole blood, the populations of CD45–CD146+ desquamated endothelial cells and progenitor endothelial cells related to CD14+VEGFR2+ monocytes, intermediate CD14++CD16+ and non-classical CD14+CD16++ monocytes were assessed by flow cytometry using the appropriate monoclonal antibodies (BD Biosciens, USA). In blood plasma, the levels of hypoxia-inducible factor HIF-1α, monocyte chemoattractant protein MCP-1 and matrix metalloproteinase MMP-9 were assessed by enzyme immunoassay. The results of the analysis were considered significant at p<0.05.Results. The number of progenitor and desquamated endothelial cells was increased in both groups of patients with coronary artery disease. At the same time, in patients with ICM, the number of progenitor endothelial cells did not reach the number noted in patients with CHD without cardiomyopathy, while the number of desquamated endothelial cells reached the number noted in CHD patients without cardiomyopathy. There was a deficiency of non-classical monocytes and HIF-1α in the blood of patients with ICM, and an excess of intermediate monocytes and MCP-1 was observed in CHD patients without cardiomyopathy. The concentration of MMP-9 in patients with CHD corresponded to the norm, regardless of the presence of ICM.Conclusion. In ICM, in contrast to CHD without cardiomyopathy, vascular damage is associated with a deficiency of nonclassical monocytes and reduced endothelial repair due to insufficient migration of progenitor endothelial cells across the bone marrow due to HIF-1α deficiency in the blood.

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Section: Original Studiesunclassified

Blood monocytes in maintaining the balance of vascular endothelial injury and repair process in ischemic cardiomyopathy

Chumakova

Уразова

Denisenko³

et al. 2022

Kompleks. probl. serdečno-sosud. zabol.

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Peptide Composition and Identification of a Peptide with Anti-Inflammatory and Antiplatelet Properties in Cattle Prostate Extract

Savel’ev,

Mittenberg,

Aref’eva

et al. 2024

Pharm Chem J

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Clinical and laboratory phenotype of postcovid asthenic syndrome in children of primary school age

Vinogradov

2023

Perm Medical Journal

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Objective. To determine the clinical and laboratory features of the postcovid syndrome in children of primary school age. Materials and methods. The analysis of complaints and anamnesis, somatic and neurological status in 24 children who had a new coronavirus infection was carried out; the results were also analyzed according to the Subjective Asthenia Scale (version for parents), the Quality of Life Assessment Scale (version for children), the Waynes questionnaire and scheme, the functional status scale. The concentration of monocytic chemotactic factor in the saliva was determined using enzyme immunoassay. Results. Most of the children presented astheno-vegetative complaints, which were confirmed by the MFS scores, and the Wayne's questionnaire and scheme. The concentration of monocytic chemotactic protein in the examined cohort of children was 32.48 23.22 pg/ml, with no significant difference by sex. The level of physical functioning by the quality of life scale was significantly higher in boys (100.00 0.00 points) than in girls (82.03 15.46 points, p = 0.02). A correlation was obtained between the salivary monocyte chemotactic protein content and the scores obtained using the Wayne questionnaire and scheme, as well as the MFS and functional status scales. Conclusions. Vegetative and asthenic syndromes are closely related to the concentration of salivary monocyte chemotactic factor.

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Monocytic Chemotactic Protein-1 in Physiology and Medicine (Review of Literature)

Cited by 5 publications

References 15 publications

Blood monocytes in maintaining the balance of vascular endothelial injury and repair process in ischemic cardiomyopathy

Blood monocytes in maintaining the balance of vascular endothelial injury and repair process in ischemic cardiomyopathy

Peptide Composition and Identification of a Peptide with Anti-Inflammatory and Antiplatelet Properties in Cattle Prostate Extract

Clinical and laboratory phenotype of postcovid asthenic syndrome in children of primary school age

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