Monocytes promote pyroptosis of endothelial cells during lung ischemia-reperfusion via IL-1R/NF-κB/NLRP3 signaling

Zhou, Peng; Guo, Hui; Li, Yiqing; Liu, Quan; Qiao, Xinwei; Lü, Yuan; Mei, Peiyuan; Zheng, Ziming; Li, Jinsong

doi:10.1016/j.lfs.2021.119402

Cited by 23 publications

(13 citation statements)

References 37 publications

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“…In the visual organ, the long noncoding RNA H19 is involved in initiating the pyroptosis of retinal microglia caused by retinal I/R injury, suggesting that pyroptosis also exists in retinal I/R injury [ 113 ]. In the respiratory organ, pretreatment with recombinant high-mobility group box 1 protein (rHMGB1) inhibited pyroptosis of alveolar macrophages through the Keap1/Nrf2/HO-1 signaling pathway, thus fighting against lung I/R injury [ 114 ]. In addition, it has been suggested that matrix metallopeptidase 2 (MMP2) and matrix metallopeptidase 9 (MMP9) contribute to lung I/R injury via the promotion of lung pyroptosis [ 115 ].…”

Section: Pyroptosis and I/r Injurymentioning

confidence: 99%

Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury

Zheng

Chi

et al. 2022

Biomolecules

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Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction. Previous studies have shown that different types of cell death, including apoptosis, necrosis, and autophagy, can occur during I/R injury. Pyroptosis, which is characterized by cell membrane pore formation, pro-inflammatory cytokine release, and cell burst, and which differentiates itself from apoptosis and necroptosis, has been found to be closely related to I/R injury. Therefore, targeting the signaling pathways and key regulators of pyroptosis may be favorable for the treatment of I/R injury, which is far from adequate at present. This review summarizes the current status of pyroptosis and its connection to I/R in different organs, as well as potential treatment strategies targeting it to combat I/R injury.

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Section: Pyroptosis and I/r Injurymentioning

confidence: 99%

Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury

Zheng

Chi

et al. 2022

Biomolecules

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“…The statistical procedures were performed as our published paper described [ 11 ]. Date were given as the mean ± SEM or median (interquartile range) wherever appropriate.…”

Section: Methodsmentioning

confidence: 99%

“…Pyroptosis is an intrinsic inflammatory process of caspase-1-dependent programmed cell death, which is a newly discovered mode of programmed cell death in addition to apoptosis and necrosis [ 9 , 10 ]. As we describe in our published paper [ 11 ], classic pyroptosis is initiated by caspase-1-dependent inflammasomes such as NLRP3, which is one of the most common examples, which consist of pattern recognition receptors (PRR), apoptosis-associated speck-like proteins containing CARD (ASC), and effector protein caspase-1 precursors (pro-caspase-1). The NLRP3 inflammasome complex can recognize pathogen-associated molecular patterns (PAMPs) or damage-related molecular patterns (DAMPs), and promote pro-caspase-1 activation through self-cleavage into active caspase-1.…”

Section: Introductionmentioning

confidence: 99%

“…Studies show that pyroptosis plays an important role in the development of infectious, atherosclerotic, and neurological-related diseases [ 13 – 15 ]. Our previous study showed that human alveolar epithelial cells co-cultured with monocytes under hypoxia–reoxygenation conditions underwent pyroptosis, suggesting that cell pyroptosis may be involved in LIRI [ 11 ]. However, the mechanisms of its function require further elucidation.…”

Section: Introductionmentioning

confidence: 99%

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MMP2 and MMP9 contribute to lung ischemia–reperfusion injury via promoting pyroptosis in mice

et al. 2022

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Background Lung ischemia–reperfusion injury (LIRI) is a cause of poor prognosis in several lung diseases and after lung transplantation. In LIRI, matrix metalloproteinases and pyroptosis indicators change in parallel, both of them involvement of inflammatory modulation, but it is unclear whether they are related to each other. Methods We analyzed the matrix metalloproteinases (MMPs) changes from RNA sequencing (RNA-Seq) data of human transplantation and rat ischemia–reperfusion lung tissues in the Group on Earth Observations (GEO) database. Then established the mouse LIRI model to validate the changes. Further, the severity of lung injury was measured after intervening the matrix metalloproteinases changes with their selective inhibitor during Lung ischemia–reperfusion. Meanwhile, lung, pyroptosis was assessed by assaying the activity of Caspase-1 and interleukin 1β (IL-1β) before and after intervening the matrix metalloproteinases changes. Results The RNA-Seq data revealed that matrix metallopeptidase 2 (MMP2), matrix metallopeptidase 9 (MMP9) mRNA expression was elevated both in human lung transplantation and rat lung ischemia–reperfusion tissues, consistent with the change in our mouse model. At the same time, the activity of Caspase-1 and IL-1β were increased after LIRI. While, the lung injury was attenuated for the use of MMP2 and MMP9 selective inhibitor SB-3CT. Likewise, lung pyroptosis alleviated when treatment the mice with SB-3CT in LIRI. Conclusion We conclude that MMP2 and MMP9 are involved in the process of LIRI, the mechanism of which is related to the promotion of lung pyroptosis.

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“…After analyzing blood samples from 145 sepsis patients, clinical investigators found an increased pyroptotic fraction of peripheral blood mononuclear cells (PBMCs), and the percentage of pyroptotic PBMCs was related to sepsis severity and 28-day mortality [62] . Zhou et al [63] demonstrated that during pulmonary ischemia-reperfusion injury, IL-1β from monocyte pyroptosis induced human pulmonary microvascular endothelial cell pyroptosis, resulting in cytokine production, pyroptosis activation, and pulmonary edema. Meanwhile, recent studies have delineated that the pyroptosis-related cytokines IL-1β and IL-18 are significantly elevated in the bronchoalveolar lavage fluid of ARDS patients, and specific inhibition of IL-1β and IL-18 has previously been shown to significantly alleviate lung injury [64] .…”

Section: Pyroptosis In Acute Lung Injurymentioning

confidence: 99%

Molecular mechanisms and roles of pyroptosis in acute lung injury

Wei

Zhang

Song

2022

Chinese Medical Journal

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Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), which are characterized by excessive inflammation and accompanied by diffuse injury of alveoli, can result in severe respiratory failures. The morbidity and mortality of patients remain high because the major treatments for ALI/ARDS are mainly supportive due to the lack of effective therapies. Numerous studies have demonstrated that the aggravation of coronavirus disease 2019 (COVID-19) leads to severe pneumonia and even ARDS. Pyroptosis, a biological process identified as a type of programed cell death, is mainly triggered by inflammatory caspase activation and is directly meditated by the gasdermin protein family, as well as being associated with the secretion and release of pro-inflammatory cytokines. Clinical and experimental evidence corroborates that pyroptosis of various cells in the lung, such as immune cells and structural cells, may play an important role in the pathogenesis of “cytokine storms” in ALI/ARDS, including those induced by COVID-19. Here, with a focus on ALI/ARDS and COVID-19, we summarized the recent advances in this field and proposed the theory of an inflammatory cascade in pyroptosis to identify new targets and pave the way for new approaches to treat these diseases.

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Monocytes promote pyroptosis of endothelial cells during lung ischemia-reperfusion via IL-1R/NF-κB/NLRP3 signaling

Cited by 23 publications

References 37 publications

Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury

Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury

MMP2 and MMP9 contribute to lung ischemia–reperfusion injury via promoting pyroptosis in mice

Molecular mechanisms and roles of pyroptosis in acute lung injury

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