Monocytes Modulate the in Vitro Basal Frequency of Sister Chromatid Exchanges of Plasma Leukocyte Cultures and Mitotic Activity of Suppressor-Cytotoxic T8 Human Lymphocytes
Abstract:The effect of monocytes (MNs) on baseline SCEs and kinetics of human lymphocytes in plasma leukocyte (PLCs) and whole blood cultures (WBCs) was studied. Baseline SCEs in PLCs were nearly two-fold over WBCs. No differences in SCEs were observed between PLCs and MN-depleted PLCs, indicating that SCEs from PLCs are independent of MNs. MNs titration into PLCs decreased proportionally SCEs. Reconstitution of depleted PLCs with concentration of MNs equivalent or higher than those of PLC decreased SCEs. No variations… Show more
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