“…Metabolic activity (King et al, 1977), in vivo phagocytic capacity (Margarey & Baum, 1977) and Fc-receptor expression (Rhodes,1 977b) are increased but, conversely, migration in vivo (Dizon & Southam, 1963) and in vitro (Snyderman et al, 1977) is decreased. Monocyte production from marrow in animals is increased (Meuret et al, 1977) but recent reports suggest that the ability of monocytes to mature into macrophages in vitro is reduced (Currie & Hedley, 1977;Taylor & Currie, 1979). This lack of ability to mature has been shown to be related to prognosis in primary breast cancer (Taylor & Currie, 1979) and to be restored by treatment with Corynebacteriurn parvurn in patients with malignant melanoma (Hedley et al, 1979).…”